Opportunity Information: Apply for RFA DA 14 006
Apply for RFA DA 14 006
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on May 3, 2013 and posted on May 3, 2013.
- Applicants must submit their applications by Aug 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts For profit organizations other than small businesses Small businesses Public housing authorities/Indian housing authorities County governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21) opportunity (Funding Opportunity Number RFA-DA-14-006) is a National Institutes of Health (NIH) grant announcement aimed at supporting exploratory, early-stage research on how chronic exposure to abused substances affects the brain through changes in energy use at the molecular level. The central theme is the relationship between molecular mechanisms that regulate how the brain generates and uses energy, and the downstream brain and behavioral effects seen in substance use disorders. In practical terms, the program is looking for projects that connect biological regulation of energy metabolism in the brain to addiction-relevant outcomes, such as neuroadaptations, cognitive or emotional changes, and other behavioral shifts that emerge with long-term drug exposure.
This is a discretionary grant mechanism using the NIH R21 activity code, which is typically designed for innovative, high-impact ideas that may still be in the earlier phases of development. The announcement was posted on May 3, 2013, with an application closing date of August 15, 2013, and an archive date of September 15, 2013. The stated award ceiling is $200,000, and the opportunity does not require cost sharing or matching funds. The program falls under the Drug Abuse and Addiction Research Programs CFDA listing (93.279), placing it squarely within NIH research priorities related to drug abuse, addiction science, and mechanisms that contribute to substance use disorders.
A notable feature of this FOA is its broad eligibility. A wide range of applicant organizations can apply, including public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (other than small businesses), small businesses, state and local governments, independent school districts, public housing authorities/Indian housing authorities, special district governments, and tribal governments and tribal organizations. The eligibility language also explicitly includes many institution types that NIH frequently encourages to participate, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions. Importantly, the FOA allows non-U.S. entities to apply, including foreign organizations and foreign institutions, as well as foreign components of U.S. organizations, consistent with NIH policy on foreign participation and foreign components.
Overall, the opportunity is designed for investigators who want to explore how disrupted or altered brain energy utilization and its molecular regulators may contribute to the biology of addiction and to behavioral outcomes associated with chronic drug exposure. It encourages work that ties together molecular regulation, brain energy pathways, and measurable brain or behavioral changes, with the broader aim of improving scientific understanding of substance use disorders and potentially revealing new avenues for prevention or treatment research. For the complete announcement and any detailed requirements that were in effect at the time, NIH provided an additional information link through the NIH Grants Guide: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-14-006.html.
Frequently Asked Questions (FAQs)
What is the full name of this funding opportunity?
The opportunity is titled "Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21)".
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-DA-14-006.
Which agency is offering this grant opportunity?
This is a National Institutes of Health (NIH) grant announcement.
What is the main purpose or research focus of this FOA?
The FOA supports exploratory, early-stage research on how chronic exposure to abused substances affects the brain through molecular-level changes in brain energy generation and utilization. The central theme is connecting molecular mechanisms that regulate brain energy use with downstream brain and behavioral effects relevant to substance use disorders.
What types of scientific connections is the program looking for?
The program is looking for projects that link molecular regulation of energy metabolism in the brain to addiction-relevant outcomes, such as neuroadaptations and measurable cognitive, emotional, or other behavioral changes that develop with long-term drug exposure.
What grant mechanism (activity code) does this FOA use?
This opportunity uses the NIH R21 activity code, described as a mechanism intended for innovative, high-impact ideas that may be in earlier stages of development.
Is this considered exploratory or early-stage funding?
Yes. The FOA explicitly emphasizes exploratory, early-stage research consistent with the R21 mechanism.
What is the maximum award amount (award ceiling)?
The stated award ceiling is $200,000.
Does the opportunity require cost sharing or matching funds?
No. The FOA states that cost sharing or matching is not required.
What are the key dates listed in the announcement?
The announcement was posted on May 3, 2013. The application closing date is listed as August 15, 2013. The archive date is listed as September 15, 2013.
What program area or CFDA listing is associated with this opportunity?
The FOA is associated with the Drug Abuse and Addiction Research Programs CFDA listing 93.279.
Is this opportunity tied to NIH priorities in drug abuse and addiction research?
Yes. The FOA is positioned within NIH research priorities related to drug abuse, addiction science, and mechanisms contributing to substance use disorders, specifically focusing on molecular regulation of brain energy utilization.
Who is eligible to apply?
The FOA describes broad eligibility that includes many organization types, including:
- Public and private institutions of higher education
- Nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities)
- For-profit organizations (other than small businesses)
- Small businesses
- State and local governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Special district governments
- Tribal governments and tribal organizations
Does the FOA specifically encourage applications from certain institution types?
Yes. The eligibility language explicitly includes institution types NIH frequently encourages to participate, such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally controlled colleges and universities
- Alaska Native and Native Hawaiian serving institutions
- Asian American and Native American Pacific Islander-serving institutions
Are non-U.S. entities eligible to apply?
Yes. The FOA allows non-U.S. entities to apply, including foreign organizations, foreign institutions, and foreign components of U.S. organizations, consistent with NIH policy on foreign participation and foreign components.
What kinds of outcomes or endpoints does the FOA emphasize?
Based on the description provided, the FOA emphasizes outcomes that are relevant to substance use disorders, including brain changes (neuroadaptations) and behavioral outcomes such as cognitive or emotional changes that emerge with chronic drug exposure.
What is the broader goal of the funded research?
The broader aim is to improve scientific understanding of substance use disorders by clarifying how altered brain energy utilization and its molecular regulators may contribute to addiction biology and behavioral outcomes, potentially pointing toward new avenues for prevention or treatment research.
Where can applicants find the complete NIH announcement?
The FOA indicates that complete details are available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-14-006.html
Is this described as a discretionary grant mechanism?
Yes. The FOA is described as a discretionary grant mechanism using the NIH R21 activity code.
What is the central scientific theme in one sentence?
The central theme is the relationship between molecular mechanisms that regulate brain energy generation and use and the downstream brain and behavioral effects observed in substance use disorders following chronic exposure to abused substances.
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