Opportunity Information: Apply for RFA DA 14 005
Apply for RFA DA 14 005
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on May 3, 2013 and posted on May 3, 2013.
- Applicants must submit their applications by Aug 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R01)" (Funding Opportunity Number RFA-DA-14-005) is a discretionary National Institutes of Health (NIH) research grant program focused on drug abuse and addiction research (CFDA 93.279). Its central goal is to support R01 projects that examine how the molecular control of brain energy use interacts with, contributes to, or is altered by chronic exposure to abused substances, and how those energy-related molecular changes relate to downstream brain changes and behavioral outcomes. In practical terms, the FOA is aimed at studies that connect cellular and molecular mechanisms of energy utilization in the brain (for example, pathways that regulate metabolism, mitochondrial function, glucose handling, oxidative balance, or other bioenergetic processes) with the neurobiological and behavioral consequences observed in substance use disorders, especially under conditions of long-term drug exposure.
This opportunity sits at the intersection of neuroscience, metabolism, and addiction biology. The announcement frames addiction-related outcomes not only in terms of receptors and neurotransmitters, but also in terms of the brain's energetic demands and how neurons and glia meet those demands. Chronic exposure to substances can reshape neural circuits, plasticity, and stress responses, and this FOA highlights that such changes may be closely tied to molecular regulators of energy production and consumption in the brain. Projects responsive to the FOA would therefore be expected to directly investigate this interplay, rather than treating metabolic regulation as a side observation. The emphasis on chronic exposure also signals interest in longer-term adaptations (and potentially persistent or progressive changes) rather than purely acute drug effects.
Mechanistically, the FOA is broad in the sense that it does not restrict applicants to a single drug class or a single pathway, but narrow in its requirement that brain energy utilization and its molecular regulation be central to the hypothesis. Work could potentially span multiple levels of analysis, including molecular and cellular studies, systems neuroscience approaches, or behavioral research, as long as the proposal ties molecular regulation of energy use in the brain to drug-induced brain and/or behavioral changes. The R01 mechanism implies the agency is looking for well-justified, hypothesis-driven projects with sufficient scope and rigor to support a multi-year research plan.
From an administrative and eligibility standpoint, this is an NIH grant using the standard R01 research project grant mechanism (Funding Instrument Type: Grant; Activity Category: Health/Education as listed). Cost sharing or matching is not required. The listed award ceiling is $350,000, which indicates the FOA set an upper bound for budgets under this solicitation (applicants would still be expected to align budget requests with NIH policy and the specific instructions in the full announcement). The opportunity was posted on May 3, 2013, with an original and current closing date of August 15, 2013, and an archive date of September 15, 2013, meaning it is a past opportunity rather than an open, active competition today.
Eligibility is expansive and includes a wide range of domestic and international organizations. Eligible applicants include state and local governments (including counties, cities/townships, special district governments), public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, and multiple categories of nonprofit organizations (both 501(c)(3) and non-501(c)(3), including those other than institutions of higher education). The FOA also allows participation by small businesses and other for-profit organizations, public housing authorities/Indian housing authorities, and tribal entities, including federally recognized Native American tribal governments as well as other tribal organizations. The additional eligibility language explicitly includes minority-serving institutions and related categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions, and non-domestic components of U.S. organizations may participate. Foreign components (as defined by the NIH Grants Policy Statement) are allowed, which is a meaningful signal that NIH anticipated scientifically relevant expertise or study populations may exist outside the United States.
The administering agency is the National Institutes of Health, and the FOA is associated with NIH drug abuse and addiction research programs. The full announcement was made available through the NIH grants guide, and the provided contact pathway is through the NIH Office of Extramural Research (OER) web support for access or linking issues (FBOWebmaster@OD.NIH.GOV). Overall, the solicitation can be summarized as an NIH R01 initiative designed to deepen mechanistic understanding of substance use disorders by focusing on how chronic drug exposure intersects with the molecular machinery that governs brain energy utilization, with the expectation that this line of research could clarify why and how long-term substance use leads to enduring changes in brain function and behavior.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-14-005.
Which agency is administering this grant opportunity?
The administering agency is the National Institutes of Health (NIH).
What type of award mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism. The funding instrument type is a grant.
What is the main scientific goal of this FOA?
The central goal is to support R01 projects that examine how molecular control of brain energy utilization interacts with, contributes to, or is altered by chronic exposure to abused substances, and how those energy-related molecular changes relate to downstream brain changes and behavioral outcomes in substance use disorders.
What research areas does this FOA sit at the intersection of?
This FOA sits at the intersection of neuroscience, metabolism (bioenergetics), and addiction biology, with an emphasis on connecting molecular energy regulation in the brain to addiction-related neurobiological and behavioral changes.
What does the FOA mean by "brain energy utilization" in practical research terms?
Based on the FOA description, brain energy utilization refers to cellular and molecular mechanisms that regulate how the brain produces and uses energy, such as pathways affecting metabolism, mitochondrial function, glucose handling, oxidative balance, and other bioenergetic processes, and how those mechanisms relate to substance use disorder outcomes.
Does the FOA focus on acute drug effects or long-term exposure?
The FOA emphasizes chronic exposure to abused substances, signaling interest in longer-term adaptations and potentially persistent or progressive changes rather than purely acute drug effects.
What kinds of outcomes should projects connect to molecular energy regulation?
Projects are expected to tie molecular regulation of brain energy use to downstream brain changes (such as circuit changes, plasticity, and stress response alterations) and/or behavioral outcomes relevant to substance use disorders.
Is the FOA limited to one drug class or one biological pathway?
No. The FOA is broad in that it does not restrict applicants to a single drug class or a single pathway. However, it is narrow in requiring that molecular regulation of brain energy utilization be central to the hypothesis and study aims.
What levels of analysis are considered responsive to the FOA?
The FOA indicates that responsive work could span multiple levels of analysis, including molecular and cellular studies, systems neuroscience approaches, or behavioral research, as long as the proposal directly links molecular regulation of brain energy utilization to drug-induced brain and/or behavioral changes.
What does the FOA indicate about the expected style and scope of the research plan?
Because the mechanism is an R01, the FOA implies the agency is seeking well-justified, hypothesis-driven projects with sufficient scope and rigor to support a multi-year research plan.
What is the CFDA number associated with this program?
The CFDA number listed is 93.279.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the listed award ceiling?
The listed award ceiling is $350,000, indicating an upper bound for budgets under this solicitation (with the expectation that applicants align budget requests with NIH policy and the full announcement instructions).
When was this opportunity posted?
The opportunity was posted on May 3, 2013.
What were the closing date and archive date?
The original and current closing date was August 15, 2013, and the archive date was September 15, 2013.
Is this an active funding opportunity today?
No. Based on the provided dates (closing in 2013 and archived in 2013), it is a past opportunity rather than an open, active competition today.
Who is eligible to apply?
Eligibility is expansive and includes a wide range of domestic and international organizations. Eligible applicants include state and local governments (including counties, cities/townships, and special district governments), public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, nonprofit organizations (both 501(c)(3) and non-501(c)(3), including those other than institutions of higher education), small businesses and other for-profit organizations, public housing authorities/Indian housing authorities, tribal entities (including federally recognized Native American tribal governments and other tribal organizations), U.S. territories or possessions, regional organizations, and eligible federal agencies.
Are minority-serving institutions specifically included in eligibility?
Yes. The additional eligibility language explicitly includes minority-serving institutions and related categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Can faith-based or community-based organizations apply?
Yes. The eligibility language explicitly includes faith-based and community-based organizations.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA states that non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions.
Can non-domestic components of U.S. organizations participate?
Yes. The FOA allows non-domestic components of U.S. organizations to participate.
Are foreign components allowed under this FOA?
Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed.
What is the best contact for access or linking issues related to the announcement?
The provided contact pathway for access or linking issues is the NIH Office of Extramural Research (OER) web support: FBOWebmaster@OD.NIH.GOV.
Where was the full announcement made available?
The FOA indicates the full announcement was made available through the NIH grants guide.
How does this FOA frame addiction-related brain changes?
The FOA frames addiction-related outcomes not only in terms of receptors and neurotransmitters, but also in terms of the brain's energetic demands and how neurons and glia meet those demands, especially under chronic substance exposure.
What makes a project "responsive" versus only tangentially related?
Based on the description provided, a responsive project would directly investigate the interplay between chronic substance exposure and the molecular regulators of brain energy utilization, rather than treating metabolic regulation as a side observation or secondary outcome.
What overall purpose does NIH highlight for this line of research?
The solicitation is designed to deepen mechanistic understanding of substance use disorders by focusing on how chronic drug exposure intersects with the molecular machinery that governs brain energy utilization, with the expectation that this may clarify why and how long-term substance use leads to enduring changes in brain function and behavior.
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| Funding Opportunity |
|---|
| Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21) Apply for RFA DA 14 006 Funding Number: RFA DA 14 006 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Integration and Analysis of Diverse HIV Associated Data (R03) Apply for RFA MH 14 200 Funding Number: RFA MH 14 200 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50) Apply for PAR 13 222 Funding Number: PAR 13 222 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| FY14 NIDA Avant Garde Award Program for HIV/AIDS Research (DP1) Apply for RFA DA 14 008 Funding Number: RFA DA 14 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Integrating Substance Abuse Prevention and Treatment within HIV/AIDS Service Delivery Settings (R01) Apply for RFA DA 14 011 Funding Number: RFA DA 14 011 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| HIV/AIDS and Substance Use among Black/African American Women and Young MSM (R01) Apply for RFA DA 14 010 Funding Number: RFA DA 14 010 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01) Apply for RFA DA 14 009 Funding Number: RFA DA 14 009 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Comorbid HIV, Chronic Pain, and Substance Use among Older Adults (R21) Apply for RFA DA 14 012 Funding Number: RFA DA 14 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research to Characterize and Reduce Stigma to Improve Health (R21) Apply for PA 13 246 Funding Number: PA 13 246 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research to Characterize and Reduce Stigma to Improve Health (R03) Apply for PA 13 247 Funding Number: PA 13 247 Agency: National Institutes of Health Category: Education Health Funding Amount: $100,000 |
| Research to Characterize and Reduce Stigma to Improve Health (R01) Apply for PA 13 248 Funding Number: PA 13 248 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Adult Brain Tumor Consortium (ABTC) (UM1) Apply for RFA CA 13 501 Funding Number: RFA CA 13 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $2,000,000 |
| Limited Competition Pediatric Brain Tumor Consortium (UM1) Apply for RFA CA 13 502 Funding Number: RFA CA 13 502 Agency: National Institutes of Health Category: Education Health Funding Amount: $2,590,000 |
| Clinical Trials and Interventional Studies of Non Pharmacological Approaches to Managing Pain and Co Morbid Conditions in U.S. Military Personnel, Veterans, and their Families (R01) Apply for RFA AT 14 003 Funding Number: RFA AT 14 003 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Pilot and Feasibility Studies of Non Pharmacological Approaches to Managing Pain and Co Morbid Conditions in U.S. Military Personnel, Veterans, and their Families (R34) Apply for RFA AT 14 004 Funding Number: RFA AT 14 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $225,000 |
| Health Services and Observational Studies of Non Pharmacological Approaches to Managing Pain and Co Morbid Conditions in U.S. Military Personnel, Veterans, and their Families (R01) Apply for RFA AT 14 005 Funding Number: RFA AT 14 005 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Program Project Grant Applications (P01) Apply for PAR 13 259 Funding Number: PAR 13 259 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Synergizing Omic and Symptom Science (R15) Apply for PA 13 265 Funding Number: PA 13 265 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Synergizing Omic and Symptom Science (R01) Apply for PA 13 264 Funding Number: PA 13 264 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Grand Opportunity in Medications Development for Substance Use Disorders (U01) Apply for PAR 13 270 Funding Number: PAR 13 270 Agency: National Institutes of Health Category: Education Health Funding Amount: $5,000,000 |
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