DoD Neurofibromatosis New Investigator Award | Apply Online

Opportunity Summary:

The DoD Neurofibromatosis New Investigator Award (NIA) is a funding opportunity under the Department of Defense Neurofibromatosis Research Program (NFRP) designed to help promising early-stage, independent researchers build or strengthen their careers in neurofibromatosis (NF) research. First introduced in FY1999, the program has a track record that shows it is competitive but established: 179 applications had been received over time, with 38 recommended for funding. The central goal is career transition and continued development, meaning it is aimed at investigators who are ready to lead their own NF-focused projects and establish themselves as independent contributors to the field.

A key feature of this award is that prior NF experience is allowed but not required. That makes it accessible to strong investigators coming from related disciplines who want to pivot into NF research. At the same time, the program signals that applicants without deep NF background should partner with a collaborator who has demonstrated NF expertise, which helps ensure the project is grounded in the realities of NF biology, clinical care, and the needs of the patient community. Another non-negotiable requirement is that applications must include preliminary data that relate to NF and to the proposed work. That preliminary evidence can come from the principal investigator, the research team, or a collaborator, but it needs to show that the approach is feasible and connected to NF in a concrete way.

For FY2010, the opportunity specifically encourages proposals that target urgent and practical needs in the NF community. One priority area is complications associated with high mortality, including cancers or tumor-related disease (neoplasms) and cerebrovascular abnormalities. A second priority area focuses on complications that may not be as immediately life-threatening but cause major long-term disability or reduced functioning (high morbidity). Examples listed include skeletal problems, learning deficits, hormone-associated effects, and pain, all of which can significantly impact daily life and long-term outcomes for people living with NF. A third encouraged area is the refinement and standardization of tools needed to make future clinical trials stronger and more comparable across sites, such as imaging techniques, molecular and cellular markers, and quality-of-life metrics. A fourth area emphasizes translational research, particularly the development of therapeutic candidates or preclinical testing of potential treatments, reflecting an interest in moving discoveries toward real-world interventions even if the work is not yet at the stage of testing in patients.

Human subjects research is permitted under this mechanism, but clinical trials are explicitly not allowed. The announcement uses a standard definition of a clinical trial as a prospective study in which an intervention (such as a drug, device, behavioral program, surgery, or similar) is tested in human subjects to measure an outcome. Applicants who want to run a clinical trial are directed instead to the FY2010 NFRP Clinical Trial Award mechanism. The notice also points applicants to the program’s general application instructions for rules and expectations related to human subjects, human data, or human anatomical substances, which suggests that compliance, ethical review, and proper handling of human-derived materials are taken seriously even when a project stops short of an interventional trial.

Administratively, this opportunity was posted March 2, 2010, with a closing date of May 20, 2010, and it was run by the Department of the Army through USAMRAA. The funding instrument types listed include cooperative agreement and grant, and the activity category is science and technology and other research and development. The program anticipated making about three awards, with an estimated total funding pool of $1.8 million, and it did not require cost sharing or matching funds. Eligibility was described as unrestricted, meaning a wide range of applicant organizations could apply, subject to any additional clarifications in the full announcement. The opportunity is associated with CFDA 12.420 (Military Medical Research and Development) and carried the funding opportunity number W81XWH-10-NFRP-NIA. Contact resources were provided through CDMRP support channels for technical issues accessing the announcement or using the electronic submission systems.

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