DoD Neurofibromatosis Exploration Hypothesis Development Award | Apply Online

Opportunity Summary:

The DoD Neurofibromatosis Exploration - Hypothesis Development Award (EHDA) is a Department of Defense funding opportunity run through the Neurofibromatosis Research Program (NFRP) under the U.S. Army Medical Research and Acquisition Activity (USAMRAA). It is designed to help researchers take early, exploratory steps on new ideas in neurofibromatosis and/or schwannomatosis, especially ideas that are innovative, high-risk, and potentially high-reward. The award is meant to generate the kind of initial findings that either justify building a brand-new hypothesis or establish early guiding principles for an unconventional hypothesis. A core theme of the mechanism is giving investigators room to follow promising, even unexpected, observations rather than requiring a fully mature research plan backed by extensive preliminary results.

A key expectation is that the Principal Investigator clearly explains what makes the proposed work novel and why it represents a genuinely innovative direction for the field. Preliminary data can be included and may strengthen an application, but it is not required, which signals that the program is intentionally set up to support early-stage concept testing rather than later-stage validation. Historically, the program had received 46 applications since it began in FY08, with 13 recommended for funding, underscoring that it is competitive and selective.

Because this mechanism is intended for preliminary investigations, it places strict limits on human subjects research. Projects involving human subjects or human specimens are generally not supported unless they qualify as exempt under 32 CFR 219.101(b) or are eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110. Applications that propose human research that does not meet exempt or expedited criteria are not simply scored poorly; they are administratively withdrawn. Researchers who want to run a clinical trial are directed to use a separate Clinical Trial Award mechanism instead, meaning the EHDA is not the right vehicle for trial-based clinical studies.

For FY10, the program explicitly encouraged proposals aligned with pressing needs in the NF community. Priority themes included complications associated with high mortality, such as tumors (neoplasms) and cerebrovascular abnormalities, as well as high-morbidity complications like skeletal problems, learning deficits, hormone-related effects, and pain. The program also encouraged work that improves the tools needed for future clinical trials, including refining and standardizing imaging methods, molecular and cellular markers, and quality-of-life measures. Another emphasized area was translational research, particularly development or preclinical testing of therapeutic agents aimed at treating NF.

Administratively, this opportunity was posted March 2, 2010, and closed May 20, 2010 (archived June 19, 2010). It used grant and cooperative agreement instruments under a science and technology research and development category, with an estimated total funding level of $750,000 and an expectation of about five awards. There was no cost-sharing requirement, and eligibility was described as unrestricted (open to any entity type, subject to any clarifications in the full announcement). The funding opportunity number was W81XWH-10-NFRP-EHDA and the CFDA number listed was 12.420 (Military Medical Research and Development). Contact points were provided through the CDMRP help resources for assistance with accessing the announcement and with electronic submission.

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