Opportunity Information: Apply for W81XWH 10 TSCRP EHDA
Apply for W81XWH 10 TSCRP EHDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Exploration Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 2, 2010 and posted on Mar 2, 2010.
- Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $900,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Tuberous Sclerosis Complex Research Program (TSCRP) Exploration - Hypothesis Development Award (EHDA) is a discretionary research funding opportunity run through the Department of the Army (USAMRAA) that is meant to seed brand-new directions in tuberous sclerosis complex (TSC) research. The purpose is very early-stage exploration: the program is looking for ideas that are innovative, high risk, and potentially high reward, including concepts that could be considered unconventional or even speculative as long as they are well argued. The expectation is that the work funded under this mechanism will generate the kind of initial evidence or guiding observations that can justify a new hypothesis or lay out the first principles of an emerging hypothesis, setting applicants up for later, larger studies.
A defining feature of this award is its emphasis on novelty and discovery rather than maturity. Preliminary data is encouraged because it can strengthen the case that the approach is feasible, but it is not required, which signals that applicants can propose bold projects that do not yet have extensive supporting results. At the same time, the burden is placed squarely on the Principal Investigator to clearly explain what is truly innovative about the idea and why it could matter for TSC. In practical terms, a competitive application would need to show that the project is not just incremental, that it takes advantage of a fresh insight (including a serendipitous or unexpected observation), and that the potential impact on understanding, preventing, or treating TSC is credible even if the path is uncertain.
Because the EHDA is meant for preliminary investigations, there are important restrictions related to human research. Studies involving human subjects or human specimens generally will not be supported unless the work qualifies as exempt under 32 CFR 219.101(b) or is eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110. The announcement makes this a strict gatekeeping rule: applications proposing human work that does not meet exempt or expedited criteria will be administratively withdrawn rather than simply scored poorly. Applicants therefore need to design projects that are largely non-human (for example, using cell systems, animal models, or computational approaches) or ensure that any human-related component clearly fits within the allowable regulatory categories and can be documented accordingly.
The funding instrument is listed as either a cooperative agreement or a grant, and the activity category is science and technology and other research and development. The opportunity is identified by Funding Opportunity Number W81XWH-10-TSCRP-EHDA, with a total estimated funding level of about $900,000 and an expected six awards. There is no cost sharing or matching requirement, and eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full text of the announcement. The opportunity was originally posted March 2, 2010, with an application closing date of May 20, 2010 (and an archive date of June 19, 2010), indicating this is a specific fiscal year offering rather than a permanently open program.
For logistical support, the announcement directs applicants who have trouble accessing the full posting to contact PA HELP at 301-619-7079 or cdmrp.pa@amedd.army.mil, and for electronic submission support (eReceipt) to call 301-682-5507 or email help@cdmrp.org. Overall, the EHDA is best understood as a launchpad mechanism: it funds the earliest experimental or conceptual steps needed to turn a promising, high-impact idea in TSC research into a testable hypothesis with enough justification to compete for larger follow-on funding.
Frequently Asked Questions (FAQs)
What is the TSCRP Exploration - Hypothesis Development Award (EHDA)?
The Exploration - Hypothesis Development Award (EHDA) is a discretionary research funding opportunity under the DoD Tuberous Sclerosis Complex Research Program (TSCRP), managed through the Department of the Army (USAMRAA). It is designed to seed brand-new directions in tuberous sclerosis complex (TSC) research by supporting very early-stage exploration and hypothesis development.
What is the main purpose of this award?
The purpose is to support innovative, high-risk, potentially high-reward ideas that can generate initial evidence or guiding observations. The goal is to justify a new hypothesis or establish first principles for an emerging hypothesis, positioning the work for later, larger studies.
What kind of research does the EHDA emphasize?
The EHDA emphasizes novelty and discovery over project maturity. It is meant for early exploratory work, including ideas that are unconventional or speculative, as long as they are well argued and plausibly relevant to TSC.
Are high-risk or unconventional ideas allowed?
Yes. The EHDA specifically seeks innovative, high-risk, high-reward concepts. Unconventional or even speculative approaches can be appropriate if the application clearly explains the rationale and why the idea could matter for TSC.
Is preliminary data required to apply?
No. Preliminary data is encouraged because it can strengthen feasibility, but it is not required. This is intended to make room for bold projects that do not yet have extensive supporting results.
How important is innovation in the application?
Innovation is a defining feature of this mechanism. Applicants are expected to clearly explain what is truly new about the idea, why it is not incremental, and why it could credibly impact understanding, prevention, or treatment of TSC even if the outcome is uncertain.
What should a competitive EHDA application demonstrate?
Based on the announcement description, a competitive application should show that the project is not incremental, is driven by a fresh insight (including a serendipitous or unexpected observation), and has a credible potential impact on TSC-related science or outcomes, even if the path to that impact is uncertain.
Are studies involving human subjects allowed?
Human subjects research is generally not supported unless the proposed work qualifies as exempt under 32 CFR 219.101(b) or is eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110.
Are studies using human specimens allowed?
Studies involving human specimens are generally not supported unless they qualify as exempt under 32 CFR 219.101(b) or are eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110. Applicants need to ensure any human-related component clearly fits allowable regulatory categories and can be documented accordingly.
What happens if an application includes non-exempt, non-expedited human research?
The announcement describes this as a strict gatekeeping rule: applications proposing human work that does not meet exempt or expedited criteria will be administratively withdrawn rather than simply receiving a poor score.
If human research is restricted, what kinds of approaches are more appropriate?
The opportunity indicates that applicants should design projects that are largely non-human (for example, using cell systems, animal models, or computational approaches), or ensure that any human component is clearly exempt or eligible for expedited review under the cited regulations.
Who runs and administers this funding opportunity?
The EHDA is part of the DoD Tuberous Sclerosis Complex Research Program (TSCRP) and is run through the Department of the Army (USAMRAA).
What funding instrument will be used?
The funding instrument is listed as either a cooperative agreement or a grant.
What activity category does this opportunity fall under?
The activity category is listed as "science and technology and other research and development."
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is W81XWH-10-TSCRP-EHDA.
How much total funding is estimated for this opportunity?
The total estimated funding level is about $900,000.
How many awards are expected to be made?
The announcement indicates an expected six awards.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications included in the full text of the announcement.
When was this opportunity posted and when did it close?
The opportunity was originally posted on March 2, 2010, and the application closing date was May 20, 2010. An archive date of June 19, 2010 is also listed, indicating this was a specific fiscal year offering rather than a permanently open program.
What should applicants do if they cannot access the full posting?
The announcement directs applicants to contact PA HELP at 301-619-7079 or by email at cdmrp.pa@amedd.army.mil for trouble accessing the full posting.
Where can applicants get help with electronic submission (eReceipt)?
For eReceipt submission support, applicants are directed to call 301-682-5507 or email help@cdmrp.org.
How should this award be understood in a broader research funding plan?
The EHDA is positioned as a launchpad mechanism: it funds the earliest experimental or conceptual steps needed to turn a promising idea in TSC research into a testable hypothesis with enough justification to pursue larger follow-on funding.
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