Opportunity Information: Apply for W81XWH 10 TSCRP CARTA
Apply for W81XWH 10 TSCRP CARTA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex Career Transition Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 2, 2010 and posted on Mar 2, 2010.
- Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Tuberous Sclerosis Complex Career Transition Award (CARTA) is a funding opportunity under the Department of Defense Tuberous Sclerosis Complex Research Program (TSCRP) designed to help promising tuberous sclerosis complex (TSC) researchers move from postdoctoral training into an independent, faculty-level position. The core purpose is career development and independence: it supports applicants who are finishing their postdoctoral work and need a structured, well-supported pathway to launch their own research program focused on TSC. A defining feature is that the postdoctoral candidate, not the mentor or host institution, is treated as the Principal Investigator (PI), emphasizing the applicant's ownership of the research and career plan.
The award is structured to span up to four years total, split into two phases. First, it can fund up to the last two years of a postdoctoral fellowship, during which the PI is expected to receive mentored training and build the foundation for an independent research trajectory. Second, it can fund up to the first two years of a faculty-level appointment, specifically to bridge the vulnerable period when a new investigator is establishing a lab, generating publishable results, and competing for longer-term funding. Because the award is explicitly a transition mechanism, applications are expected to present a clear and credible career transition and development plan, showing how the PI will acquire needed skills, move into independence, and position themselves for sustained contributions to the TSC field.
Mentorship is a required element during the postdoctoral portion of the award. Applicants must name a mentor who will support and guide the PI through the mentored training period, and the application should make it clear what the mentor will provide (scientific guidance, professional development, access to resources, and a supportive environment) and how the relationship will help the PI become independent by the faculty phase. In addition to the career components, the scientific proposal must be grounded in TSC relevance and include preliminary data that support the feasibility and rationale of the proposed work; this mechanism is not intended for purely speculative projects without a data-driven foundation.
The opportunity is research-focused and specifically excludes clinical trials. Applicants who want to conduct a clinical trial are directed to use the TSCRP Clinical Research Award mechanism instead, which is designed for that purpose. This limitation matters for project planning: applicants should ensure their proposed aims fit within non-trial research activities (for example, mechanistic studies, preclinical work, translational research short of a trial, biomarker discovery and validation activities that do not constitute a trial, or other TSC-relevant investigations aligned with TSCRP priorities).
Administratively, this FY10 opportunity was released by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), and listed under Funding Opportunity Number W81XWH-10-TSCRP-CARTA. The instrument type is a cooperative agreement grant, within the Science and Technology and other Research and Development activity category. The program anticipated making 1 award with an estimated total funding level of $500,000, and it carried no cost sharing or matching requirement. Eligibility was listed as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement. The opportunity was posted on March 2, 2010, with an application deadline of May 20, 2010, and an archive date of June 19, 2010. For applicant support, contact points included PA HELP at 301-619-7079 (cdmrp.pa@amedd.army.mil), eReceipt HELP at 301-682-5507 (help@cdmrp.org), and the CDMRP Help Desk.
DoD Tuberous Sclerosis Complex Career Transition Award (CARTA) - FAQs
What is the DoD Tuberous Sclerosis Complex Career Transition Award (CARTA)?
The DoD Tuberous Sclerosis Complex Career Transition Award (CARTA) is a funding opportunity under the Department of Defense Tuberous Sclerosis Complex Research Program (TSCRP) intended to help promising tuberous sclerosis complex (TSC) researchers transition from postdoctoral training into an independent, faculty-level position.
What is the main purpose of this award?
The core purpose is career development and independence. It supports applicants who are finishing postdoctoral work and need a structured pathway to launch an independent research program focused on TSC.
Who is considered the Principal Investigator (PI) on a CARTA application?
A defining feature of CARTA is that the postdoctoral candidate is treated as the Principal Investigator (PI), rather than the mentor or host institution. This emphasizes the applicant's ownership of the research and career development plan.
How long can the CARTA award last, and how is it structured?
The award can span up to four years total and is split into two phases: up to the last two years of a postdoctoral fellowship (mentored phase), followed by up to the first two years of a faculty-level appointment (independent phase) to bridge the early period of establishing a lab and securing longer-term funding.
What is expected during the postdoctoral (mentored) phase?
During the postdoctoral portion, the PI is expected to receive mentored training and build the foundation for an independent research trajectory, supported by a required mentor relationship.
What is expected during the faculty-level phase?
During the faculty-level portion, the award is intended to support the PI as they establish a lab, generate publishable results, and compete for longer-term funding, consistent with the award's transition-to-independence purpose.
Is a career transition and development plan required?
Yes. Applications are expected to present a clear and credible career transition and development plan that explains how the PI will acquire needed skills, move into independence, and position themselves for sustained contributions to the TSC field.
Is mentorship required?
Yes. Mentorship is a required element during the postdoctoral portion of the award. Applicants must name a mentor who will support and guide the PI through the mentored training period.
What should the application say about the mentor's role?
The application should clearly describe what the mentor will provide, such as scientific guidance, professional development, access to resources, and a supportive environment, and how the mentoring relationship will help the PI become independent by the faculty phase.
Does the scientific proposal need to be related to tuberous sclerosis complex (TSC)?
Yes. The scientific proposal must be grounded in TSC relevance and aligned with the intent of the TSCRP.
Is preliminary data required?
Yes. The proposal must include preliminary data that support the feasibility and rationale of the proposed work. This mechanism is not intended for purely speculative projects without a data-driven foundation.
Are clinical trials allowed under CARTA?
No. The opportunity specifically excludes clinical trials.
If my project is a clinical trial, what should I apply to instead?
Applicants who want to conduct a clinical trial are directed to use the TSCRP Clinical Research Award mechanism, which is designed for that purpose.
What kinds of research activities fit under CARTA, given the clinical trial exclusion?
Applicants should ensure their proposed aims fit within non-trial research activities. Examples mentioned include mechanistic studies, preclinical work, translational research short of a trial, and biomarker discovery and validation activities that do not constitute a trial, or other TSC-relevant investigations aligned with TSCRP priorities.
What is the Funding Opportunity Number for this CARTA announcement?
The Funding Opportunity Number listed is W81XWH-10-TSCRP-CARTA.
Which DoD office released this opportunity?
This FY10 opportunity was released by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What type of award instrument is CARTA?
The instrument type is a cooperative agreement grant.
How many awards were expected, and what was the estimated total funding?
The program anticipated making 1 award with an estimated total funding level of $500,000.
Is cost sharing or matching required?
No. The opportunity carried no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was listed as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement.
When was the opportunity posted, and what were the key dates?
The opportunity was posted on March 2, 2010. The application deadline was May 20, 2010, and the archive date was June 19, 2010.
Where can applicants get help or support with the application process?
Applicant support contact points included PA HELP at 301-619-7079 (cdmrp.pa@amedd.army.mil), eReceipt HELP at 301-682-5507 (help@cdmrp.org), and the CDMRP Help Desk.
What was the activity category associated with this funding opportunity?
The opportunity was listed under the Science and Technology and other Research and Development activity category.
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