Opportunity Information: Apply for W81XWH 16 OCRP CDA
Apply for W81XWH 16 OCRP CDA
- The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Ovarian Cancer Clinical Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 16, 2016 and posted on Mar 16, 2016.
- Applicants must submit their applications by Aug 10, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Ovarian Cancer Research Program (OCRP) Clinical Development Award (CDA) is a funding opportunity designed to move ovarian cancer innovations out of the preclinical stage and into real-world clinical use as quickly as possible. Its central focus is translation: taking a promising product, technology, or approach that already has solid preliminary support and advancing it toward clinical application in prevention, detection, diagnosis, treatment, or quality-of-life improvement for people affected by ovarian cancer. The emphasis is on near-term clinical impact, meaning proposals are expected to lead to tangible, clinically relevant outcomes on a relatively short timeline rather than exploratory or early discovery work.
A key requirement of this award mechanism is that proof-of-concept must already be established. Applicants need to show that the proposed product or technology has demonstrated potential utility, or that a prototype or preliminary version already exists and is credible enough to justify clinical evaluation. Because the intent is to accelerate clinical introduction rather than generate basic preclinical evidence, animal studies are explicitly not allowed under this mechanism. Instead, the award supports work closer to the clinic, including small-scale clinical trials such as Phase 0 studies, Phase 1 trials, or pilot clinical studies. It also allows projects that enrich or strengthen a clinical trial, as well as studies that are related to, built around, or associated with ongoing or completed clinical trials, which can include activities like refining endpoints, validating biomarkers in a trial context, optimizing clinical protocols, or analyzing and leveraging clinical trial-linked samples or data when tied to a clear development pathway.
Strong justification is expected. Applications must include relevant supporting data that underpin the scientific rationale for the proposed clinical development effort. This evidence can be published or unpublished, but it needs to be sufficiently convincing to demonstrate that the project is ready for a clinical-stage push and that the proposed next steps are logical and feasible. Overall, the CDA is structured to fund efforts that can realistically advance a medical product or technology aimed at ovarian cancer biology into clinical testing or clinical readiness, rather than funding foundational experiments meant to establish whether an idea might work in principle.
Administratively, this opportunity was issued by the Department of Defense (DOD-AMRAA) under Funding Opportunity Number W81XWH-16-OCRP-CDA, categorized as a discretionary program supporting science, technology, and research and development (CFDA 12.420). Funding could be provided through either a cooperative agreement or a grant. Eligibility was listed as unrestricted, meaning it was open to any entity type (subject to any additional eligibility clarifications in the full announcement). The posting and creation dates were March 16, 2016, and the application closing date was August 10, 2016. The opportunity anticipated making around three awards, with the award ceiling not specified in the provided summary.
Frequently Asked Questions (FAQs)
What is the DoD Ovarian Cancer Research Program (OCRP) Clinical Development Award (CDA)?
The OCRP Clinical Development Award (CDA) is a Department of Defense funding opportunity intended to move ovarian cancer innovations from the preclinical stage into real-world clinical use as quickly as possible. It is built around translation, meaning it supports clinical-stage advancement of a product, technology, or approach that already has solid preliminary support and is ready to be pushed toward clinical application.
What is the main goal or focus of this award?
The central focus is near-term clinical impact. The award is designed for projects expected to produce tangible, clinically relevant outcomes on a relatively short timeline. It is not intended for exploratory ideas or early discovery research.
What kinds of ovarian cancer areas can be supported?
Projects advancing a product, technology, or approach toward clinical application in ovarian cancer prevention, detection, diagnosis, treatment, or quality-of-life improvement are within scope, as long as they align with the award's clinical development and translation emphasis.
Does the CDA require proof-of-concept before applying?
Yes. A key requirement is that proof-of-concept must already be established. Applicants are expected to show the proposed product or technology has demonstrated potential utility, or that a prototype or preliminary version exists and is credible enough to justify clinical evaluation.
Are animal studies allowed under this award mechanism?
No. Animal studies are explicitly not allowed under this mechanism. The intent is to accelerate clinical introduction rather than fund basic preclinical evidence generation.
What types of clinical studies are supported?
The CDA supports work close to the clinic, including small-scale clinical trials such as Phase 0 studies, Phase 1 trials, or pilot clinical studies. It can also support activities that enrich or strengthen a clinical trial.
Can the award support projects linked to an ongoing or completed clinical trial?
Yes. The opportunity allows studies that are related to, built around, or associated with ongoing or completed clinical trials, as long as the work is tied to a clear development pathway toward clinical readiness or clinical testing.
What are examples of activities that could strengthen or enrich a clinical trial under this award?
Examples described include refining endpoints, validating biomarkers in a trial context, optimizing clinical protocols, and analyzing or leveraging clinical trial-linked samples or data when connected to a clear clinical development pathway.
What kind of supporting evidence is expected in the application?
Applications must include relevant supporting data that underpin the scientific rationale for the proposed clinical development effort. The supporting evidence can be published or unpublished, but it needs to be convincing enough to show the project is ready for a clinical-stage push and that the proposed next steps are logical and feasible.
Is this award meant for basic research or early discovery work?
No. The CDA is structured to fund efforts that realistically advance a medical product or technology into clinical testing or clinical readiness, rather than foundational experiments meant to determine whether an idea might work in principle.
Who issued this funding opportunity?
The opportunity was issued by the Department of Defense (DOD-AMRAA) under the DoD Ovarian Cancer Research Program (OCRP).
What is the Funding Opportunity Number for this CDA?
The Funding Opportunity Number is W81XWH-16-OCRP-CDA.
What is the CFDA number and program category listed for this opportunity?
The summary lists CFDA 12.420 and categorizes the opportunity as a discretionary program supporting science, technology, and research and development.
What funding instrument(s) could be used for awards under this opportunity?
Funding could be provided through either a cooperative agreement or a grant.
Who is eligible to apply?
Eligibility was listed as unrestricted, meaning it was open to any entity type, subject to any additional eligibility clarifications in the full announcement.
When was the opportunity posted and when did it close?
The posting and creation dates were March 16, 2016, and the application closing date was August 10, 2016.
How many awards were anticipated?
The opportunity anticipated making around three awards.
What was the maximum award amount (award ceiling)?
The award ceiling was not specified in the provided summary.
What does "near-term clinical impact" mean in this context?
In this context, near-term clinical impact means the proposal should be positioned to deliver tangible, clinically relevant outcomes relatively quickly, reflecting a readiness to advance into clinical testing or clinical readiness rather than spending the project period establishing basic feasibility.
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