Opportunity Information: Apply for W81XWH 16 OCRP IIRA

  • The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Ovarian Cancer Investigator-Initiated Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 16, 2016 and posted on Mar 16, 2016.
  • Applicants must submit their applications by Aug 10, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 6 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 16 OCRP IIRA

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Opportunity Summary:

The DoD Ovarian Cancer Investigator-Initiated Research Award (IIRA) is a funding opportunity under the Department of Defense Ovarian Cancer Research Program (OCRP) designed to support high-impact, investigator-driven projects that can make a meaningful contribution to ovarian cancer research or to the care of patients and survivors. The intent is to back research that is likely to move the field forward in a substantive way, whether by improving understanding of disease biology, advancing detection or prevention approaches, identifying or validating therapeutic targets, refining treatment strategies, or addressing patient-centered outcomes and survivorship needs. The emphasis is on work that can clearly justify its potential importance and relevance to ovarian cancer, rather than incremental or weakly supported ideas.

Projects can be proposed across a broad span of the research pipeline, including basic laboratory studies and translational research, but clinical trials are explicitly excluded. In practical terms, this means applicants can pursue mechanistic studies, biomarker discovery and validation efforts (short of trial-based testing), preclinical therapeutic development, model system development, or translational analyses using relevant samples and datasets, as long as the work does not cross into conducting an interventional clinical trial. The award aims to enable well-reasoned, scientifically grounded research that has a plausible pathway to improving outcomes for individuals affected by ovarian cancer.

A central competitiveness requirement is the strength of the scientific rationale. Applications are expected to show clear logical reasoning based on a critical review and analysis of existing literature, demonstrating that the proposed aims are built on what is known, address a significant gap or barrier, and are supported by a coherent conceptual framework. In addition, preliminary data are required and must be directly relevant to ovarian cancer. These data should substantiate feasibility and provide evidence that the core premise of the project is credible, reducing uncertainty about whether the approach can realistically succeed.

Administratively, this opportunity was posted on March 16, 2016, by DOD-AMRAA (the U.S. Army Medical Research Acquisition Activity). The funding opportunity number is W81XWH-16-OCRP-IIRA, and it falls under CFDA 12.420. The instrument types listed include both grants and cooperative agreements, indicating that awards may vary in the degree of federal involvement in project oversight depending on the specific mechanism used. Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications provided in the full announcement. The original and current closing date for applications was August 10, 2016, and the program anticipated making around six awards. The award ceiling is not specified in the provided summary, so applicants would typically need to consult the full funding announcement for budget limits and other detailed submission requirements.

DoD Ovarian Cancer Investigator-Initiated Research Award (IIRA) - FAQs

What is the DoD Ovarian Cancer Investigator-Initiated Research Award (IIRA)?

The DoD Ovarian Cancer Investigator-Initiated Research Award (IIRA) is a funding opportunity within the Department of Defense Ovarian Cancer Research Program (OCRP) intended to support high-impact, investigator-driven research projects that can meaningfully advance ovarian cancer research or improve care for patients and survivors.

What kinds of research does this award support?

This award supports projects across a broad portion of the research pipeline, including basic laboratory research and translational research. Examples described in the opportunity include mechanistic studies, biomarker discovery and validation (short of trial-based testing), preclinical therapeutic development, development of model systems, and translational analyses using relevant samples and datasets.

What is the main goal or intent of the IIRA?

The intent is to back research that is likely to move the ovarian cancer field forward in a substantive way. This can include improving understanding of disease biology, advancing detection or prevention approaches, identifying or validating therapeutic targets, refining treatment strategies, and addressing patient-centered outcomes and survivorship needs.

Are clinical trials allowed under this funding opportunity?

No. Clinical trials are explicitly excluded under this funding opportunity.

Does the opportunity emphasize innovative, high-impact work over incremental projects?

Yes. The emphasis is on work that can clearly justify its potential importance and relevance to ovarian cancer rather than incremental or weakly supported ideas.

What makes an application competitive for this award?

A central competitiveness requirement is the strength of the scientific rationale. Applications are expected to present clear logical reasoning grounded in a critical review and analysis of the existing literature, show that the proposed aims address a significant gap or barrier, and demonstrate a coherent conceptual framework.

Are preliminary data required?

Yes. Preliminary data are required.

Do the preliminary data need to be specific to ovarian cancer?

Yes. The preliminary data must be directly relevant to ovarian cancer and should support feasibility and the credibility of the project premise.

What should the preliminary data demonstrate?

The preliminary data should substantiate feasibility and provide evidence that the core premise of the project is credible, helping to reduce uncertainty about whether the proposed approach can realistically succeed.

Who posted this funding opportunity?

The opportunity was posted by DOD-AMRAA (the U.S. Army Medical Research Acquisition Activity).

When was this opportunity posted?

The opportunity was posted on March 16, 2016.

What is the funding opportunity number?

The funding opportunity number is W81XWH-16-OCRP-IIRA.

What CFDA number is associated with this opportunity?

The opportunity is listed under CFDA 12.420.

What types of award instruments are available (grant vs. cooperative agreement)?

The instrument types listed include both grants and cooperative agreements. This indicates awards may differ in the degree of federal involvement in project oversight depending on the mechanism used.

Who is eligible to apply?

Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications contained in the full announcement.

What was the application deadline?

The original and current closing date for applications was August 10, 2016.

How many awards were anticipated?

The program anticipated making around six awards.

Is the maximum award amount (ceiling) provided in the summary?

No. The award ceiling is not specified in the provided summary. Applicants would typically need to consult the full funding announcement for budget limits and detailed submission requirements.

What types of outcomes or impacts are encouraged?

The opportunity emphasizes research with a plausible pathway to improving outcomes for individuals affected by ovarian cancer, including patients and survivors. Supported impacts may involve better understanding of disease biology, improved detection or prevention approaches, therapeutic target identification/validation, refined treatment strategies, and survivorship or patient-centered outcomes.

Can projects include translational analyses using samples or datasets?

Yes. Translational analyses using relevant samples and datasets are within the described scope, as long as the work does not involve conducting an interventional clinical trial.

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