Opportunity Information: Apply for W81XWH 09 PRCRP CA
Apply for W81XWH 09 PRCRP CA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Peer Reviewed Cancer Research Program Concept Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jun 18, 2009 and posted on Jun 18, 2009.
- Applicants must submit their applications by Jul 30, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 11 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award (FY09) is a Department of the Army/USAMRAA funding opportunity designed to back very early-stage, high-risk cancer research ideas that could open up entirely new directions in the field. The intent is to support the exploration of a truly innovative concept or an untested theory rather than funding the next step of an existing, well-developed research program. Projects funded under this mechanism are expected to generate insight or early findings that could later serve as the foundation for a larger, follow-on proposal, but applicants are not allowed to include preliminary data in their submissions. Instead, the application must make a clear, compelling rationale for why the idea is credible and worth testing despite its high-risk nature.
For FY09, this Concept Award is limited to two congressionally directed topic areas only, and applications outside these areas are not permitted. The first topic area is noninvasive cancer ablation research, including selective targeting using nanoparticles. The second is genetic cancer research focused on how cancer risk and mechanisms relate to exposures and environments that are distinctive to military life. A major restriction is that proposals must not address breast, prostate, or ovarian cancer research, even if the approach would otherwise fit the program goals. Applications are reviewed and rated largely on how directly and convincingly they align with the specified focus areas under the chosen topic.
Within the genetic cancer research topic, the program is looking for studies that connect military-relevant exposures or stressors to changes in gene structure and/or gene expression that may increase cancer risk, whether those exposures act alone or in combination. The announcement highlights examples of hazards that can be relevant to military populations, such as radiation (including UV and other sources), biological agents, chemical exposures, physical and psychological stress, and other environmental conditions like noise, heat, or altitude. Beyond identifying genetic changes, the program also encourages work that investigates the biological pathways involved in carcinogenic mechanisms influenced by these exposures, explores the possibility of trans-generational cancer risk linked to military exposures, and evaluates whether different ethnic groups may have different genetic susceptibility patterns in the context of those exposures. Applicants choosing this topic area have an added responsibility: they must clearly and explicitly explain the military relevance of the proposed work, rather than assuming it is self-evident.
Within the noninvasive cancer ablation topic, the focus areas are more technology- and targeting-centered. The program is interested in the development of approaches that enable ablation technologies to reach deep organs effectively (addressing the challenge of accessing tumors that are not near the surface) and in validating nanoparticle targeting, meaning work that tests and supports the idea that nanoparticles can be directed selectively to cancerous tissue or other intended targets to improve precision and reduce harm to healthy tissue. In keeping with the Concept Award’s purpose, proposed ablation or targeting approaches should be bold and exploratory, aiming to demonstrate feasibility or reveal a new pathway for future development rather than incrementally refining an already mature platform.
Administratively, this FY09 opportunity was posted June 18, 2009, with an original and final closing date of July 30, 2009, and an archive date of August 29, 2009. The funding instrument type is listed as cooperative agreement and grant under the science and technology/research and development category, with no cost sharing or matching requirement. The program anticipated making around 11 awards, with an estimated total funding amount of $1.3 million. Eligibility is described as unrestricted, meaning it is broadly open to different entity types, subject to any additional clarifications in the full announcement. The opportunity is associated with CFDA 12.420 (Military Medical Research and Development) and the funding opportunity number W81XWH-09-PRCRP-CA. For practical support, the announcement provides contact points for help accessing the announcement and for electronic submission assistance through the CDMRP helpdesk.
FAQs - DOD Peer Reviewed Cancer Research Program (PRCRP) Concept Award (FY09)
What is the PRCRP Concept Award (FY09)?
The PRCRP Concept Award (FY09) is a Department of Defense (Department of the Army/USAMRAA) funding opportunity intended to support very early-stage, high-risk cancer research concepts. It is designed to help investigators explore a truly innovative idea or untested theory that could open new directions in cancer research, rather than advance the next step of an established research program.
What is the main purpose of this Concept Award mechanism?
The purpose is to fund exploratory work that can generate initial insight or early findings that may serve as the foundation for a future, larger follow-on proposal. The emphasis is on testing credibility and feasibility of a bold concept, not refining a mature approach.
Are preliminary data allowed in the application?
No. Applicants are not allowed to include preliminary data. Instead, the application must provide a clear and compelling rationale explaining why the idea is credible and worth testing despite being high-risk.
What topic areas are eligible for FY09?
For FY09, applications are limited to two congressionally directed topic areas only:
- Noninvasive cancer ablation research, including selective targeting using nanoparticles
- Genetic cancer research focused on how cancer risk and mechanisms relate to exposures and environments distinctive to military life
Applications outside these two areas are not permitted.
Is research on breast, prostate, or ovarian cancer allowed?
No. A major restriction is that proposals must not address breast, prostate, or ovarian cancer research, even if the approach would otherwise fit the program goals.
How will applications be evaluated?
Applications are reviewed and rated largely on how directly and convincingly they align with the specified focus areas under the chosen topic area.
What does the program mean by "very early-stage" and "high-risk"?
Within the context provided, "very early-stage" and "high-risk" refers to research that explores a new concept or untested theory without relying on preliminary data, and that aims to open a new direction rather than extend an existing, well-developed research program.
What types of studies fit the genetic cancer research topic area?
The genetic cancer research topic seeks studies that connect military-relevant exposures or stressors to changes in gene structure and/or gene expression that may increase cancer risk. These exposures may act alone or in combination.
What military-relevant exposures or hazards are mentioned as examples?
The announcement highlights examples that can be relevant to military populations, including:
- Radiation (including UV and other sources)
- Biological agents
- Chemical exposures
- Physical stress and psychological stress
- Other environmental conditions such as noise, heat, or altitude
Beyond identifying genetic changes, what else does the genetic topic encourage?
Beyond identifying genetic changes, the program encourages work that:
- Investigates biological pathways involved in carcinogenic mechanisms influenced by military-relevant exposures
- Explores the possibility of trans-generational cancer risk linked to military exposures
- Evaluates whether different ethnic groups may have different genetic susceptibility patterns in the context of those exposures
Do applicants in the genetic cancer topic have to explain military relevance?
Yes. Applicants choosing the genetic cancer research topic must clearly and explicitly explain the military relevance of the proposed work rather than assuming it is self-evident.
What types of projects fit the noninvasive cancer ablation topic area?
The noninvasive cancer ablation topic is focused on technology and targeting concepts, including:
- Developing approaches that enable ablation technologies to reach deep organs effectively (addressing tumors not near the surface)
- Validating nanoparticle targeting (testing and supporting the idea that nanoparticles can be selectively directed to cancerous tissue or other intended targets)
What does "validating nanoparticle targeting" mean in this announcement?
In this announcement, validating nanoparticle targeting refers to work that tests and supports the concept that nanoparticles can be directed selectively to cancerous tissue (or other intended targets) to improve precision and reduce harm to healthy tissue.
Does the ablation topic prioritize incremental improvements to existing platforms?
No. Proposed ablation or targeting approaches are expected to be bold and exploratory, aiming to demonstrate feasibility or reveal a new pathway for future development rather than incrementally refining an already mature platform.
When was this FY09 opportunity posted and when did it close?
This FY09 opportunity was posted on June 18, 2009. The original and final closing date was July 30, 2009. The archive date was August 29, 2009.
What is the funding instrument type?
The funding instrument type is listed as cooperative agreement and grant.
What is the program category?
The opportunity is under the science and technology / research and development category.
Is cost sharing or matching required?
No. The opportunity indicates there is no cost sharing or matching requirement.
How many awards were anticipated and what was the total estimated funding?
The program anticipated making around 11 awards, with an estimated total funding amount of $1.3 million.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to different entity types, subject to any additional clarifications in the full announcement.
What is the CFDA number for this opportunity?
The opportunity is associated with CFDA 12.420 (Military Medical Research and Development).
What is the funding opportunity number?
The funding opportunity number is W81XWH-09-PRCRP-CA.
Where can applicants get help with accessing the announcement or electronic submission?
The announcement provides contact points for help accessing the announcement and for electronic submission assistance through the CDMRP helpdesk.
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