Opportunity Information: Apply for RFA MH 10 010
Apply for RFA MH 10 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Identification and Characterization of Sensitive Periods for Neurodevelopment in Studies of Mental Illness (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Jun 18, 2009 and posted on Jun 18, 2009.
- Applicants must submit their applications by Oct 20, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institute of Mental Health (NIMH) released this Funding Opportunity Announcement (FOA), RFA-MH-10-010, to support research that pinpoints and explains "sensitive periods" in brain development as they relate to mental illness. In this context, sensitive periods are specific windows of development when the brain is especially responsive to environmental inputs, meaning experiences during that time can more strongly push development toward risk for psychopathology or toward resilience and healthy outcomes. The overall aim is to move beyond broad ideas like "early life matters" and instead define when, how, and why particular developmental windows are uniquely important for shaping cognitive function, emotional regulation, and behaviors tied to mental health disorders.
Projects proposed under this FOA are expected to investigate sensitive periods in several complementary ways. Applications can focus on sensitive periods that shape typical development, or on periods where disruptions or adverse experiences may alter trajectories toward psychopathology. A major emphasis is also on identifying sensitive periods that are most promising for intervention, including prevention, pre-emption (acting before full disorder onset), and treatment, with the idea that intervening at the right developmental moment may produce larger or more durable benefits than intervening earlier or later. Another central theme is mechanism: the FOA encourages work that clarifies how genes, experience, and developmental processes interact, since sensitive periods are often thought to emerge from the timing of neurobiological maturation combined with environmental exposures.
The mechanism of support is the NIH Research Project Grant (R01), which is intended for more mature, hypothesis-driven projects with a substantial scope of work. This announcement ran in parallel with a companion FOA of the same scientific scope that used the R21 Exploratory/Developmental mechanism (RFA-MH-10-011), which is typically used for earlier-stage or higher-risk pilot efforts. Together, the paired FOAs were designed to fund both foundational exploratory studies and more comprehensive projects aimed at definitive characterization of sensitive periods and related mechanisms.
In terms of funding, NIMH anticipated committing about $5,000,000 in fiscal year 2010 to support roughly 10 to 15 total awards across this FOA and its companion announcement. There is no cost sharing or matching requirement. The opportunity falls under the health category and aligns with CFDA 93.242 (Mental Health Research Grants).
Eligibility is broad and includes many types of institutions and organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), state governments, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized tribal governments. The FOA also explicitly includes a range of other eligible entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and non-U.S. (foreign) organizations.
Administratively, the FOA was posted on June 18, 2009, with an original and current closing date of October 20, 2009, and an archive date of November 20, 2009. The full announcement was hosted by NIH, and applicants were directed to the NIH Grants Guide link for complete details. For access or technical issues, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the purpose of FOA RFA-MH-10-010?
This Funding Opportunity Announcement (FOA) from the National Institute of Mental Health (NIMH) supports research to pinpoint and explain "sensitive periods" in brain development as they relate to mental illness. The goal is to move beyond broad statements like "early life matters" and instead define when, how, and why specific developmental windows are especially important for shaping mental health outcomes.
What does NIMH mean by "sensitive periods" in this FOA?
In this FOA, sensitive periods are specific windows of development when the brain is especially responsive to environmental inputs. Experiences during these windows can have a stronger influence on developmental trajectories, potentially increasing risk for psychopathology or supporting resilience and healthy outcomes.
What kinds of outcomes or traits are emphasized in the research goals?
The FOA highlights developmental windows that shape cognitive function, emotional regulation, and behaviors tied to mental health disorders. Projects are expected to clarify the unique importance of particular developmental periods for these outcomes.
Do proposed projects need to focus on mental illness, or can they focus on typical development?
Applications may focus on sensitive periods that shape typical development, or on sensitive periods where disruptions or adverse experiences may alter developmental trajectories toward psychopathology.
What types of research approaches are encouraged under this FOA?
Projects are expected to investigate sensitive periods in complementary ways, including defining when sensitive windows occur, how experiences during those windows influence development, and why those windows are uniquely influential compared to earlier or later time points.
Is intervention research part of the FOA's emphasis?
Yes. A major emphasis is identifying sensitive periods that are most promising for intervention, including prevention, pre-emption (acting before full disorder onset), and treatment. The FOA underscores the idea that intervening at the right developmental moment may produce larger or more durable benefits than intervening earlier or later.
What does the FOA say about mechanisms and causes?
The FOA encourages work that clarifies mechanisms by examining how genes, experience, and developmental processes interact. It notes that sensitive periods are often thought to emerge from the timing of neurobiological maturation combined with environmental exposures.
What funding mechanism is used for RFA-MH-10-010?
The mechanism of support is the NIH Research Project Grant (R01), which is intended for more mature, hypothesis-driven projects with a substantial scope of work.
Is there a companion funding opportunity related to this FOA?
Yes. This announcement ran in parallel with a companion FOA of the same scientific scope using the R21 Exploratory/Developmental mechanism (RFA-MH-10-011), which is typically used for earlier-stage or higher-risk pilot efforts.
How were the paired FOAs intended to work together?
Together, the R01 and R21 FOAs were designed to fund both foundational exploratory studies and more comprehensive projects aimed at definitive characterization of sensitive periods and related mechanisms.
How much funding did NIMH expect to commit, and how many awards were anticipated?
NIMH anticipated committing about $5,000,000 in fiscal year 2010 to support roughly 10 to 15 total awards across this FOA and its companion announcement.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the CFDA number and category for this opportunity?
The opportunity aligns with CFDA 93.242 (Mental Health Research Grants) and falls under the health category.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), state governments, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized tribal governments.
Are specific institution types explicitly included (such as minority-serving institutions)?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and other similar entities.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly lists faith-based or community-based organizations among eligible entities.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA includes U.S. territories or possessions among eligible entities.
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies in its list of eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly includes non-U.S. (foreign) organizations as eligible applicants.
When was the FOA posted and what were the key dates?
The FOA was posted on June 18, 2009. The original and current closing date was October 20, 2009, and the archive date was November 20, 2009.
Where were applicants directed to find full details?
The full announcement was hosted by NIH, and applicants were directed to the NIH Grants Guide link for complete details.
Who should be contacted for access or technical issues related to the announcement?
For access or technical issues, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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