Opportunity Information: Apply for W81XWH 10 PRCRP TNIA
Apply for W81XWH 10 PRCRP TNIA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Peer Reviewed Cancer Translational New Investigator Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on May 20, 2010 and posted on May 20, 2010.
- Applicants must submit their applications by Oct 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD Peer Reviewed Cancer Translational New Investigator Award (PRCRP TNIA) is a fiscal year 2010 funding opportunity from the Department of the Army (USAMRAA) under the Peer Reviewed Cancer Research Program (PRCRP). It was introduced for the first time in FY10 and is designed to help launch the careers of new investigators by supporting highly collaborative, translational cancer research projects that are clearly tied to one or more FY10 PRCRP Topic Areas and are relevant to military beneficiaries. The core purpose is to push promising scientific observations toward practical clinical use, meaning the work should be positioned to inform real-world patient care even if the research itself is not conducted directly in a clinical setting.
A central requirement of this award is a true two-investigator partnership built around translation and mentorship. The application must be led by a new investigator serving as the Principal Investigator (PI), paired with an established mentor who already runs a research program in a relevant PRCRP topic area. The partnership must include two independent investigators, with one being a laboratory scientist and the other a clinician. This structure is meant to ensure the project benefits from both bench and bedside expertise, and the program explicitly expects a reciprocal flow of ideas and information across the team. In practical terms, the research plan should show how clinical insight helps shape laboratory work and how laboratory findings are intended to feed back into clinically meaningful next steps.
From a scientific scope standpoint, the award supports translational, preclinical studies that use animal models and/or human anatomical substances and that have a clear path toward eventual clinical application. The announcement emphasizes that projects should include human anatomical substances (for example, tissue or blood) even if the work is not performed in the clinic. It also allows correlative studies connected to an existing clinical trial, as well as projects that develop clinical endpoints intended to support future clinical trials, as long as the proposed work itself does not test an intervention in humans as a trial.
Human subject participation is allowed, but with an important limitation: clinical trials are not permitted under this mechanism. The program uses a standard definition of a clinical trial as a prospective human study that tests an intervention (such as a drug, device, behavioral approach, or surgical procedure) and measures outcomes. What is permitted instead are correlative Human Subject Use studies, which may be prospective or retrospective and generally involve collecting and analyzing human anatomical substances or related data (such as tissue, blood, bone marrow, nail clippings, or behavioral documentation) to answer research questions about the disease and/or interventions. These correlative studies can be associated with a clinical trial, but they cannot be designed to assess the main outcomes of that trial and cannot directly test the effect of an intervention on prevention, diagnosis, treatment, or quality of life outcomes. Depending on the study design, informed consent may be required and identifiable information may be included, with applicants directed to the program's general application instructions for compliance details.
Administratively, the opportunity was posted on May 20, 2010, with an original and final closing date of October 20, 2010, and an archive date of November 19, 2010. It anticipated making about 10 awards with an estimated total funding level of $4.5 million. Funding could be provided as either a grant or a cooperative agreement, and there is no cost sharing or matching requirement. Eligibility was described as unrestricted, meaning a wide range of entity types could apply, subject to any additional eligibility clarifications in the full announcement. The opportunity is listed under CFDA 12.420 (Military Medical Research and Development), and applicant support was available through the CDMRP help resources and program contacts provided in the notice.
Frequently Asked Questions (FAQs)
What is the DOD Peer Reviewed Cancer Translational New Investigator Award (PRCRP TNIA)?
The PRCRP Translational New Investigator Award (TNIA) is a FY2010 Department of Defense funding opportunity administered by the Department of the Army (USAMRAA) under the Peer Reviewed Cancer Research Program (PRCRP). It was introduced for the first time in FY10 and is intended to help launch the careers of new investigators through highly collaborative, translational cancer research.
What is the main goal of this award?
The main goal is to move promising scientific observations toward practical clinical use. Projects should be positioned to inform real-world patient care, even if the proposed research itself is not conducted directly in a clinical setting.
What kind of research does the PRCRP TNIA support?
This mechanism supports translational, preclinical studies that use animal models and/or human anatomical substances and that show a clear path toward eventual clinical application. It also allows correlative studies linked to an existing clinical trial and projects that develop clinical endpoints intended to support future clinical trials, as long as the proposed work does not test an intervention in humans as a clinical trial.
Do proposed projects need to align with specific PRCRP priorities?
Yes. The project must be clearly tied to one or more FY10 PRCRP Topic Areas and must be relevant to military beneficiaries.
Is collaboration required, or is it optional?
Collaboration is a central requirement. The TNIA requires a true two-investigator partnership built around translation and mentorship.
Who must serve as the Principal Investigator (PI)?
The application must be led by a new investigator serving as the PI.
What is the role of the mentor on this award?
The mentor must be an established investigator who already runs a research program in a relevant PRCRP topic area. The mentor is part of a two-investigator partnership intended to provide mentorship while also enabling a reciprocal exchange of ideas and information to support translation.
Does the partnership require specific types of investigators (lab vs. clinician)?
Yes. The partnership must include two independent investigators, with one being a laboratory scientist and the other a clinician. This structure is intended to connect bench expertise with bedside insight.
What does the program mean by a "reciprocal flow" between the investigators?
The program expects the research plan to show two-way integration: clinical insight should help shape laboratory work, and laboratory findings should be intended to feed back into clinically meaningful next steps.
Are human anatomical substances expected to be part of the project?
Yes. The announcement emphasizes that projects should include human anatomical substances (for example, tissue or blood), even if the work is not performed in a clinical setting.
What are examples of "human anatomical substances" mentioned in the opportunity?
Examples provided include tissue, blood, bone marrow, and nail clippings. The notice also references related data sources such as behavioral documentation in the context of correlative human subject use studies.
Are human subjects allowed under this funding mechanism?
Yes, human subject participation is allowed, but with a key limitation: clinical trials are not permitted.
Are clinical trials allowed under the PRCRP TNIA?
No. Clinical trials are not permitted under this mechanism.
How does this opportunity define a clinical trial?
A clinical trial is defined as a prospective human study that tests an intervention (such as a drug, device, behavioral approach, or surgical procedure) and measures outcomes.
What types of human research are permitted if clinical trials are not allowed?
Permitted work includes correlative Human Subject Use studies, which may be prospective or retrospective and generally involve collecting and analyzing human anatomical substances or related data to answer research questions about the disease and/or interventions, without directly testing the effect of an intervention on prevention, diagnosis, treatment, or quality of life outcomes.
Can the proposed study be connected to an existing clinical trial?
Yes. Correlative studies can be associated with an existing clinical trial, but they cannot be designed to assess the main outcomes of that trial and cannot be structured to test the effect of an intervention on key patient outcomes.
Can the project develop clinical endpoints for later testing?
Yes. The opportunity allows projects that develop clinical endpoints intended to support future clinical trials, as long as the proposed work itself is not a clinical trial (i.e., it does not prospectively test an intervention in humans and measure outcomes as a trial).
Is informed consent required for the permitted human subject work?
Depending on the study design, informed consent may be required. The notice indicates applicants should follow the program's general application instructions for compliance details.
Can the study include identifiable information?
Yes, depending on the study design, identifiable information may be included. Applicants are directed to the program's general application instructions for compliance requirements.
When was this funding opportunity posted, and what were the key dates?
The opportunity was posted on May 20, 2010. The original and final closing date was October 20, 2010. The archive date was November 19, 2010.
How many awards were anticipated, and what was the estimated total funding?
It anticipated making about 10 awards, with an estimated total funding level of $4.5 million.
What funding instrument types were available?
Funding could be provided as either a grant or a cooperative agreement.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility was described as unrestricted, meaning a wide range of entity types could apply, subject to any additional eligibility clarifications in the full announcement.
What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 12.420, Military Medical Research and Development.
Where could applicants get help or support with the application?
Applicant support was available through the CDMRP help resources and the program contacts provided in the notice.
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