DoD Post Traumatic Stress Disorder In Home Therapy Clinical Trial Award | Apply Online

Opportunity Summary:

The DoD Post Traumatic Stress Disorder In Home Therapy Clinical Trial Award is a Department of Defense funding opportunity issued through the PH/TBI (Psychological Health/Traumatic Brain Injury) Research Program and administered by the U.S. Army Medical Research Acquisition Activity (USAMRAA). Introduced for the first time in fiscal year 2011, the award is designed to generate practical, decision-ready evidence about how different ways of delivering behavioral health care for PTSD perform when tested head-to-head in real clinical conditions. The core intent is comparative effectiveness research, meaning the DoD is looking for studies that directly compare treatment delivery options rather than focusing only on whether a single approach works in isolation.

At the center of this opportunity is a requirement to run a randomized controlled trial (RCT) that includes at least three treatment arms, each representing a distinct modality of care delivery: (1) traditional face-to-face therapy provided in an office or clinic setting, (2) face-to-face therapy delivered in the patient’s home, and (3) tele-behavioral health where the provider connects to the patient while the patient remains at home. The funding announcement emphasizes that these modalities should be compared within the same trial framework so that outcomes can be interpreted as true contrasts among delivery methods, rather than as separate studies with incompatible designs. In other words, the program is seeking trials that can credibly answer whether in-home therapy or telehealth can match or outperform standard office-based care for this population, and under what conditions.

The target participants are veterans from Operation Iraqi Freedom and Operation Enduring Freedom (OIF/OEF) who have returned from deployment and are currently diagnosed with PTSD and referred for behavioral health treatment. The announcement explicitly includes a broad post-deployment group, such as active duty service members after deployment, demobilized reservists, and discharged veterans. By narrowing to individuals already diagnosed and referred for care, the program is oriented toward real-world treatment delivery and access challenges rather than early screening or prevention alone.

The primary metric the DoD wants emphasized in proposed projects is treatment outcome, with an example being symptom reduction to below the diagnostic threshold for PTSD. However, the opportunity makes clear that the DoD is also interested in a fuller picture of what makes a modality workable and scalable. Applications are encouraged to compare additional dimensions such as patient compliance (for example, whether patients attend and complete sessions), treatment satisfaction, and how well a given patient can be matched to the most suitable modality. The announcement also signals operational and implementation concerns that matter to military and veteran health systems, including the ease of delivering care in each format, provider and patient safety considerations (particularly relevant for in-home visits), cost and cost-effectiveness factors, and program management issues that would affect how a clinic or system could roll out the approach.

A notable expected deliverable is a best-practice guide to implementation, indicating the DoD is not only looking for statistical comparisons but also practical guidance that decision-makers can use to adopt the most effective and feasible model(s) of PTSD therapy delivery. That implementation focus suggests applicants should think beyond clinical endpoints and plan for lessons learned about logistics, staffing, technology, safety protocols, and workflow.

From an administrative standpoint, this opportunity was posted July 8, 2011, under Funding Opportunity Number W81XWH-11-PHTBI-PTSD-IHT-CTA. The mechanism allows funding through either a cooperative agreement or a grant, and it sits within the Science and Technology and other Research and Development category. The estimated total funding was $5,000,000 with an expected 2 awards, and there was no cost-sharing or matching requirement. Eligibility was listed as unrestricted (open broadly to entity types), subject to any clarifications in the full announcement. The original closing date was October 10, 2011, later extended to November 16, 2011, with an archive date of December 16, 2011. For technical access issues, applicants were directed to the CDMRP Help Desk (301-682-5507, help@cdmrp.org).

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