Opportunity Information: Apply for W81XWH 10 PCRP HDRA
Apply for W81XWH 10 PCRP HDRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Prostate Cancer Health Disparity Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Mar 3, 2010 and posted on Mar 3, 2010.
- Applicants must submit their applications by May 26, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Prostate Cancer Health Disparity Research Award (Health Disparity Research Award, HDRA) is a funding opportunity under the Department of Defense Prostate Cancer Research Program (PCRP) that supports innovative research aimed at understanding and ultimately eliminating disparities in prostate cancer incidence, morbidity, and mortality. The program is explicitly focused on populations that are disproportionately affected by prostate cancer and is meant to generate new ideas and approaches that could meaningfully reduce suffering and deaths associated with the disease. Historically, the mechanism began in FY2001, and by the time of this FY2010 announcement it had received 177 applications with 45 recommended for funding, indicating a competitive program with selective awards.
Projects submitted under this mechanism must clearly and directly connect the proposed research to at least one recognized area of prostate cancer health disparity. The announcement highlights disparity areas such as race and ethnicity, socioeconomic status, access to health care, insurance status, age, geographic factors, and cultural beliefs, while also leaving room for other well-justified disparity dimensions. The expectation is not simply to describe unequal outcomes, but to pose a research question that advances understanding of why the disparity exists and how it might be reduced or eliminated. The mechanism spans a wide range of research from basic to clinical research, but it does not allow clinical trials. Human subjects research is allowed as long as it does not meet the definition of a clinical trial (for example, prospective intervention testing such as drugs, devices, behavioral interventions, or surgical procedures evaluated for outcomes).
A core theme of this award is innovation. Preliminary data are encouraged but not required, which is intended to lower barriers to pursuing higher-risk, creative ideas. When applicants do include preliminary data, it is expected to come from the Principal Investigator (PI) or collaborating team members, reinforcing that the proposed direction is feasible within the team’s capabilities. The program draws a clear line between truly innovative work and incremental follow-ons to published studies; proposals that mainly extend existing work in small steps are not considered responsive to the innovation emphasis.
The FY2010 version of the award was modified based on feedback gathered through a FY2009 Request for Information, which flagged common obstacles in disparity research, especially difficulty forming the right collaborations and gaining access to appropriate study populations. In response, the announcement introduced several new or strengthened components. One is the Qualified Collaborator Option, which strongly incentivizes meaningful collaboration, especially partnerships bridging basic and clinical researchers, teams combining prostate cancer expertise with health disparity expertise, and collaborations with community organizations that can enable access to affected populations. Collaborations that meet specific criteria can qualify an application for a higher funding level. To use this option, the PI must submit a Qualified Collaboration Statement and the collaborator must provide a formal letter of collaboration. The collaboration must be essential to the project (not optional), the collaborator must contribute substantial intellectual input and resources, and the collaborator must commit at least 10 percent effort with that effort reflected in the budget. If the PI lacks experience in prostate cancer research or in working with disproportionately affected populations, the collaborator is expected to bring that experience to the team.
Another FY2010 addition is the New Investigator Option, designed to encourage early-career investigators to apply by reviewing New Investigator applications separately from Established Investigator applications during peer and programmatic review. While new investigators can compete in their own review pool, the program still emphasizes assembling a team with the needed expertise; applicants are encouraged to include experienced prostate cancer and/or relevant subject-matter experts with demonstrated funding and publication records, and to explain how those collaborators strengthen the project. New Investigators are also allowed to pair this pathway with the Qualified Collaborator Option.
To further address practical barriers, the funding notice points applicants toward specific resources for identifying collaborators, locating relevant cohorts, and finding investigators already active in the area. Examples include the CDMRP awards database, the North Carolina-Louisiana Prostate Cancer Project (PCaP), NIH Reporter, DTIC technical reports, and NCI resources focused on reducing cancer health disparities. It also suggests looking to community-based participatory research networks and engaging organizations that have direct ties to underserved or disproportionately affected communities, such as the Urban League, National Medical Association, National Alliance for Hispanic Health, American Indian health organizations, rural health associations, and prostate cancer advocacy and education groups. The underlying message is that strong disparity research often depends on trust, community connections, and real access to populations, not just a good scientific hypothesis.
From a review standpoint, applicants are expected to explicitly address four main elements: the disparity-linked research question, the innovative nature of the approach, the potential impact on reducing or eliminating disproportionate prostate cancer burden, and responsiveness to at least one PCRP focus area (with optional alignment to broader PCRP overarching challenges). The impact standard is framed in practical terms: if the project succeeds, it should plausibly contribute to meaningful reductions in unequal outcomes and help accelerate progress toward reducing prostate cancer deaths and suffering overall.
Administratively, this opportunity was posted March 3, 2010, with an original and final closing date of May 26, 2010, and an archive date of June 25, 2010. It anticipated about 6 awards with an estimated total funding level of $4.3 million, and it carried no cost-sharing requirement. The opportunity is associated with Funding Opportunity Number W81XWH-10-PCRP-H-DRA and falls under CFDA 12.420 (Military Medical Research and Development). The sponsoring agency is the Department of the Army (USAMRAA) under the CDMRP framework, using grant/cooperative agreement funding instruments. Eligibility is described as unrestricted in the summary listing (open to a wide range of applicant entity types), subject to any additional constraints in the full announcement. For technical access or submission support, the notice lists PA HELP and CDMRP eReceipt Help Desk contacts.
FAQs: DoD Prostate Cancer Health Disparity Research Award (HDRA)
What is the DoD Prostate Cancer Health Disparity Research Award (HDRA)?
The Health Disparity Research Award (HDRA) is a funding mechanism within the Department of Defense (DoD) Prostate Cancer Research Program (PCRP) that supports innovative research to understand and ultimately eliminate disparities in prostate cancer incidence, morbidity, and mortality, especially in populations disproportionately affected by the disease.
What is the main goal of this award?
The goal is to generate new ideas and approaches that can meaningfully reduce unequal prostate cancer outcomes, with an emphasis on research that clarifies why disparities exist and how they might be reduced or eliminated.
What kinds of prostate cancer disparities are relevant to this award?
Projects must clearly connect to at least one recognized area of prostate cancer health disparity. The announcement highlights disparities related to race and ethnicity, socioeconomic status, access to health care, insurance status, age, geographic factors, and cultural beliefs, while allowing other well-justified disparity dimensions.
Does the proposal have to go beyond describing unequal outcomes?
Yes. The expectation is not simply to describe unequal outcomes, but to pose a research question that advances understanding of why the disparity exists and how it might be reduced or eliminated.
What types of research are allowed (basic, translational, clinical)?
The mechanism spans a wide range of research from basic to clinical research. However, clinical trials are not allowed under this award.
Are clinical trials allowed under the HDRA?
No. The award does not allow clinical trials.
Is human subjects research allowed?
Yes. Human subjects research is allowed as long as it does not meet the definition of a clinical trial (for example, prospective intervention testing such as drugs, devices, behavioral interventions, or surgical procedures evaluated for outcomes).
Is preliminary data required?
No. Preliminary data are encouraged but not required, which is intended to lower barriers for higher-risk, creative ideas.
If preliminary data are included, whose data should they be?
When preliminary data are included, it is expected to come from the Principal Investigator (PI) or collaborating team members, supporting feasibility within the team.
How does the program define or emphasize innovation?
Innovation is a core theme. The program distinguishes truly innovative work from incremental follow-ons to published studies. Proposals that mainly extend existing work in small steps are not considered responsive to the innovation emphasis.
What is the Qualified Collaborator Option?
The Qualified Collaborator Option is a FY2010 component that strongly incentivizes meaningful collaboration, particularly collaborations that help overcome common barriers in disparity research (such as forming the right partnerships and gaining access to appropriate study populations). Collaborations meeting specific criteria can qualify an application for a higher funding level.
What types of collaborations are especially encouraged?
The announcement highlights collaborations that bridge basic and clinical researchers, teams combining prostate cancer expertise with health disparity expertise, and collaborations with community organizations that enable access to disproportionately affected populations.
What is required to use the Qualified Collaborator Option?
To use this option, the PI must submit a Qualified Collaboration Statement and the collaborator must provide a formal letter of collaboration.
What qualifies a collaborator as "qualified" for this option?
The collaboration must be essential to the project (not optional). The collaborator must contribute substantial intellectual input and resources, and the collaborator must commit at least 10 percent effort, with that effort reflected in the budget.
What if the PI lacks experience in prostate cancer research or in working with disproportionately affected populations?
If the PI lacks experience in prostate cancer research or in working with disproportionately affected populations, the collaborator is expected to bring that experience to the team.
What is the New Investigator Option?
The New Investigator Option is designed to encourage early-career investigators to apply. New Investigator applications are reviewed separately from Established Investigator applications during peer and programmatic review.
Can a New Investigator also use the Qualified Collaborator Option?
Yes. New Investigators are allowed to pair the New Investigator Option with the Qualified Collaborator Option.
Does the program still expect experienced expertise on the team if applying as a New Investigator?
Yes. While reviewed in a separate pool, applicants are encouraged to include experienced prostate cancer and/or relevant subject-matter experts with demonstrated funding and publication records, and to explain how those collaborators strengthen the project.
What practical barriers in health disparity research did the FY2010 changes aim to address?
The FY2010 version was modified in response to feedback that identified difficulty forming the right collaborations and gaining access to appropriate study populations as common obstacles in disparity research.
What resources does the announcement suggest for finding collaborators or relevant cohorts?
The notice points to resources such as the CDMRP awards database, the North Carolina-Louisiana Prostate Cancer Project (PCaP), NIH Reporter, DTIC technical reports, and NCI resources focused on reducing cancer health disparities.
What kinds of community connections does the program encourage?
The announcement suggests engaging community-based participatory research networks and organizations with direct ties to underserved or disproportionately affected communities, emphasizing that strong disparity research often depends on trust, community connections, and real access to populations.
Which example organizations are mentioned for potential community engagement?
Examples listed include the Urban League, National Medical Association, National Alliance for Hispanic Health, American Indian health organizations, rural health associations, and prostate cancer advocacy and education groups.
What key elements are applicants expected to address in the application?
Applicants are expected to explicitly address: (1) the disparity-linked research question, (2) the innovative nature of the approach, (3) the potential impact on reducing or eliminating disproportionate prostate cancer burden, and (4) responsiveness to at least one PCRP focus area (with optional alignment to broader PCRP overarching challenges).
How is "impact" framed for this award?
Impact is framed in practical terms: if the project succeeds, it should plausibly contribute to meaningful reductions in unequal outcomes and help accelerate progress toward reducing prostate cancer deaths and suffering overall.
How competitive is this funding mechanism historically?
Historically, the mechanism began in FY2001 and, by the time of the FY2010 announcement, it had received 177 applications with 45 recommended for funding, indicating a selective and competitive program.
How many awards and how much total funding were anticipated for FY2010?
The FY2010 notice anticipated about 6 awards, with an estimated total funding level of $4.3 million.
Is cost sharing or matching required?
No. The opportunity carried no cost-sharing requirement.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is W81XWH-10-PCRP-H-DRA.
What CFDA number is associated with this opportunity?
This opportunity is associated with CFDA 12.420 (Military Medical Research and Development).
Which agency sponsors this opportunity?
The sponsoring agency is the Department of the Army (USAMRAA) under the CDMRP framework, using grant/cooperative agreement funding instruments.
What were the key dates for the FY2010 posting?
The opportunity was posted March 3, 2010. The original and final closing date was May 26, 2010. The archive date was June 25, 2010.
Who is eligible to apply?
Eligibility is described as unrestricted in the summary listing (open to a wide range of applicant entity types), subject to any additional constraints in the full announcement.
Where can applicants get technical or submission help?
For technical access or submission support, the notice lists PA HELP and the CDMRP eReceipt Help Desk as points of contact.
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