Opportunity Information: Apply for W81XWH 14 PCRP LCTA

The Department of Defense (DoD) Prostate Cancer Research Program (PCRP) offers a Laboratory Clinical Transition Award (LCTA) aimed at facilitating preclinical studies of innovative lead agents or medical devices that could significantly enhance prostate cancer treatment. This opportunity is available for projects focusing on the development of pharmacology and toxicology data essential for FDA Investigational New Drug (IND) applications, or for creating medical devices aimed at obtaining FDA Investigational Device Exemption (IDE) approvals.

Applicants must identify a validated lead agent or a limited set of agents prior to applying, furnishing detailed evidence regarding the agent's mechanism of action, as well as its effectiveness and reliability. The same standards apply to medical devices, which should demonstrate similar qualities. Examples of eligible lead agents include new chemotherapeutics and imaging agents, while medical devices could range from diagnostic tools to advanced imaging technologies.

Successful applications should illustrate a viable transition plan for further development phases post-award and are encouraged to include cost-sharing arrangements with commercial partners. The LCTA is particularly focused on research that addresses the PCRP’s defined priorities, with a robust approach to translational research advocated by the National Cancer Institute's developmental frameworks.

Proposals should emphasize studies like optimizing lead agents, toxicology screening, pharmacokinetic assessments, and testing the safety of medical devices, performed within a 12-month timeframe. However, the scope excludes earlier-stage research like target discovery or new combinations of agents already in testing. Proposals must also address any intellectual property considerations transparently.

In summary, the LCTA aims to drive the advancement of promising prostate cancer treatments into clinical settings, promoting collaboration and commercialization potential.

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Prostate Cancer Laboratory Clinical Transition Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on May 30, 2014 and posted on May 30, 2014.
  • Applicants must submit their applications by Oct 29, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
  • The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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