DoD Prostate Cancer Population Based Research Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Research Program (PCRP) Population Based Research Award (PBRA) is a Department of the Army funding opportunity focused on high-impact, population-based prostate cancer research. It was redesigned for FY10 after an earlier version (the FY09 Population Based Idea Development Award) received 31 applications and did not recommend any for funding. The FY10 version is meant to better support studies that use large, well-defined patient populations to produce findings that could meaningfully reduce prostate cancer deaths and suffering, especially by generating insights or tools that can only come from statistical analysis at the population level rather than from small clinical or lab-only datasets.

At its core, this award is for research built around a strong prostate-cancer-specific hypothesis that can be tested using rigorous population-based methods. Applicants can propose a range of accepted study designs, including retrospective or prospective population studies, case-control studies, cohort studies, or other epidemiologic and population-science approaches. A key expectation is that the population sample is large enough to achieve statistical significance, and that the application makes it clear the research team has both the statistical expertise and the practical access needed to carry out the analysis. In other words, it is not enough to have an interesting question; the proposal needs to show that the investigators can actually reach or already have the patient population or biospecimens required, in numbers that can support robust conclusions.

The program highlights several research areas that fit well within this mechanism, including biomarkers, predictors of response to therapy, disease aggressiveness, epidemiology, genomics (either germline or somatic), health disparities, molecular genetics, and risk prediction. These topics signal that the DoD is looking for studies that connect real-world patient variation to meaningful outcomes, such as why some tumors become aggressive, which patients respond to particular treatments, how inherited or tumor-acquired genetic changes shape risk, and how disparities across groups affect incidence, treatment, or survival. The intended payoff is research that translates into better prediction, stratification, and decision-making for prostate cancer at scale.

Human subjects research is allowed under this award, but clinical trials are not. The announcement draws a clear line around what it considers a clinical trial: a prospective study that tests an intervention (for example a drug, device, behavioral program, or surgical procedure) in human subjects and measures outcomes. Projects can still involve human subjects, human data, and human anatomical substances, but they must stay on the observational or non-interventional side, such as analyzing existing records and specimens, building risk models, validating biomarkers in cohorts, or studying population-level factors that influence outcomes.

The solicitation also lays out specific elements the Principal Investigator is expected to address directly. First is impact: the application needs to make a credible case that, if successful, the work would substantially accelerate progress toward eliminating death and suffering from prostate cancer. Second is a robust statistical plan: the study must be designed around sound statistical methods, and the team must demonstrate real statistical capability, not just mention it in passing. Third is a human subject plan focused on feasibility: applicants must document access to the population and/or samples and show the ability to recruit or obtain sufficient numbers to support statistically meaningful results. Fourth is preliminary data: feasibility support is required, and any preliminary results should come from the PI or collaborators on the project, reinforcing that the team already has a foundation for executing the work. Fifth is responsiveness: proposals must align with at least one FY10 PCRP overarching challenge and at least one focus area, meaning the study must clearly connect to the program priorities rather than being a generic population study.

Administratively, the opportunity is listed as Funding Opportunity Number W81XWH 10 PCRP PBRA, offered as a discretionary science and technology research and development program under CFDA 12.420 (Military Medical Research and Development). The funding instrument is a cooperative agreement grant, with an estimated total funding amount of $2.9 million and an expectation of about three awards. The eligibility is described as unrestricted, meaning it is broadly open to different types of applicant organizations unless further limited by details in the full announcement. No cost sharing or matching is required. The opportunity was posted March 2, 2010, with an application closing date of May 26, 2010, and an archive date of June 25, 2010. For support, the announcement points applicants to the CDMRP/USAMRAA help contacts for technical access and electronic submission assistance.

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