DoD Prostate Cancer Population Science Impact Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Research Program (PCRP) Population Science Impact Award is a Department of the Army funding opportunity designed to support high-impact population science research that can meaningfully reduce deaths from prostate cancer and/or improve quality of life for men affected by the disease. This mechanism grew out of earlier PCRP efforts (the Population Based Idea Development Award in FY09 and the Population Based Research Award in FY10 and FY11). Historically, it has been competitive, with relatively few awards recommended compared to the number of applications received. The program is looking for studies that can produce results only achievable when you study groups and systems of people at scale, rather than focusing narrowly on single patients or small clinical series.

A strong application is expected to make a clear case for major impact. Projects should directly address one of the PCRP overarching challenges, or make a compelling justification that they tackle another urgent and critical need in prostate cancer research. The announcement highlights several focus areas that are especially encouraged: genetics/genomics and biomarkers (particularly those tied to early detection of aggressive disease, prognosis, and treatment response), survivorship and palliative care, and health disparities. In practical terms, this means the program is interested in studies that can explain why certain groups develop more aggressive disease, how outcomes differ across communities or health systems, how to better predict which cancers will progress, and how men live with the long-term consequences of diagnosis and treatment.

The research supported under this award is explicitly population science in orientation. Proposed work is expected to draw on established population science disciplines and methods such as epidemiology, surveillance, health services research, outcomes research, behavioral science, social science, and dissemination research. The program envisions outputs like broadly useful datasets, analytic tools, risk models, validated measures, or evidence that can shift clinical practice or public health approaches across large cohorts, defined communities, or entire health systems. Acceptable study designs include retrospective and prospective approaches, case-control studies, cohort studies, and related population-based designs, including work leveraging biospecimens and data from existing retrospective databases, as long as the sample size is large enough to support appropriate statistical power.

Methodological rigor and feasibility are central to this opportunity. Applications are expected to present a well-developed, conceptually sound hypothesis that is specific to prostate cancer, and the study team should clearly demonstrate epidemiologic and/or biostatistical expertise in the plan. Just as important, applicants must document access to the target population(s), datasets, and/or patient samples, and show that recruitment and data availability will be sufficient to produce robust, statistically meaningful findings. In other words, reviewers will look for proof that the population-based work can actually be executed at the scale promised, not just proposed in theory.

Human subjects research is allowed, but the program draws a firm boundary around clinical trials. Clinical trials are only allowable if they are no greater than minimal risk, as determined by both the local Institutional Review Board (IRB) and the U.S. Army Medical Research and Materiel Command Office of Research Protections, Human Research Protection Office (HRPO). The announcement provides behavioral intervention studies as an example of a potentially allowable minimal-risk clinical trial scenario, such as prospective accrual where a behavioral intervention is used to evaluate an instrument, study tool, hazard, or other exploratory outcome, provided the risk remains minimal. By contrast, trials that prospectively enroll patients to test drugs, devices, biologics, or surgical procedures for outcomes related to safety, effectiveness, or efficacy are not supported under this mechanism. Correlative studies tied to such trials may be permitted if they remain minimal risk; these are defined as studies that collect human specimens or related materials (for example tissue or blood) to answer research questions about disease and/or an intervention, without directly assessing intervention outcomes like prevention, diagnosis, treatment effect, or quality-of-life improvements. Any human subjects research considered greater than minimal risk is not eligible under this award.

Administratively, this opportunity was posted May 30, 2014, with an original and final closing date of October 29, 2014, and an archive date of November 28, 2014. It was offered as a grant or cooperative agreement under Funding Opportunity Number W81XWH-14-PCRP-PSIA through the Department of the Army, USAMRAA, within the Military Medical Research and Development CFDA (12.420). The opportunity anticipated approximately three awards, with an estimated total funding amount of $3.6 million, no cost sharing requirement, and broadly unrestricted eligibility (open to many entity types, subject to any specific limitations in the full announcement). For help accessing the full announcement, the CDMRP Help Desk was listed as the primary contact.

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