DoD Prostate Cancer Research Program Impact Award | Apply Online

Opportunity Summary:

The DoD Prostate Cancer Research Program (PCRP) Impact Award (Funding Opportunity Number W81XWH-10-PCRP-IA) is a FY2010 funding mechanism from the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), designed to back a small number of highly ambitious projects that can make a major, practice-changing difference in one specific area of prostate cancer care: reducing or eliminating the overtreatment of primary prostate cancer. The central idea is that too many men diagnosed with early stage disease receive aggressive treatment even when their cancers may be indolent, and the program is looking for research that can meaningfully improve how clinicians decide who truly needs treatment and who can be safely monitored.

This opportunity uses a two-step application process. Applicants must first submit a pre-proposal (pre-application) by 5:00 p.m. Eastern Time on March 17, 2010, following instructions laid out in the Program Announcement. Full applications are not accepted from everyone; they are submitted by invitation only after the pre-proposals are screened. The award instrument is listed as a cooperative agreement or grant under the Science and Technology / Research and Development category, with an estimated total FY10 funding of about $2.4 million and an expectation of roughly two awards. Cost sharing is not required, and eligibility is broadly open (unrestricted) as long as the applicant meets any specific clarifications in the announcement.

In terms of the science, the Impact Award is explicitly geared toward hypothesis-driven research that aims to change the standard of practice for decision making in primary prostate cancer. Proposed work can be basic, translational, or clinical, and clinical trials are allowed, as long as the project remains tightly focused on the overtreatment problem. A common expectation for clinical studies is longitudinal follow-up that helps distinguish, as early as diagnosis, between patients whose disease will remain indolent and those whose disease is likely to progress to a lethal phenotype. The program signals that it values clinically meaningful endpoints tied to real decisions in care, such as progression and subsequent need for treatment, rather than purely exploratory or descriptive outcomes.

The scope of relevant approaches is intentionally broad, as long as the project clearly supports better risk stratification and more appropriate treatment selection. Examples of topic areas called out include active surveillance (such as improving or standardizing inclusion and exclusion criteria), biomarker development and validation, genetic analyses, improved staging and grading including imaging advances, better measures to guide decision making before and after biopsy, improved follow-up strategies and progression assessment, and cancer care outcomes research that captures patient-centered issues like quality of life, survivorship, and surveillance-related outcomes. The common thread across these areas is building evidence and tools that help clinicians avoid unnecessary intervention without missing aggressive disease that truly requires treatment.

Because this mechanism is labeled an "Impact Award" and is positioned as high-consequence, applications are expected to show feasibility up front. That means preliminary data are required, and the announcement emphasizes that these data should come from the principal investigator's lab or from members of the assembled research team, not from unrelated outside sources. Applicants are also expected to build a multidisciplinary team, typically involving multiple clinical specialists as needed for the question, and to include a robust statistical plan and statistical expertise. The intent is to ensure the study is designed to produce clear, credible answers that can support changes in clinical practice.

Human subjects research is permitted, including clinical trials. If the project involves clinical research, the program expects regulatory approvals to be obtained and the study to be initiated within the first year of the award, underscoring the urgency and translational intent of this mechanism. The responsibility is placed on the PI to explicitly connect the proposed research question to the program's goal of reducing overtreatment and to make a convincing case for impact, including a clear research strategy, appropriate access to any defined study population (for population-based work), and a realistic plan for generating results that could materially shift how early stage prostate cancer is managed.

Key dates listed in the announcement include the posted date of February 2, 2010, and a pre-proposal deadline of March 17, 2010 at 5:00 p.m. ET. The funding listing also shows an original closing date of April 19, 2010 and later updates extending the current closing date to June 9, 2010, with an archive date of July 9, 2010. For assistance, the announcement provides contacts for Program Announcement help (301-619-7079, cdmrp.pa@amedd.army.mil) and eReceipt/CDMRP help desk support (301-682-5507, help@cdmrp.org).

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