Opportunity Information: Apply for W81XWH 10 SCIRP TRPA
Apply for W81XWH 10 SCIRP TRPA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Spinal Cord Injury Translational Research Partnership Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Jun 18, 2010 and posted on Jun 18, 2010.
- Applicants must submit their applications by Dec 1, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $11,250,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Spinal Cord Injury Translational Research Partnership Award (TRPA) is a funding opportunity under the Spinal Cord Injury Research Program (SCIRP) run by the Department of the Army (USAMRAA) to push promising spinal cord injury (SCI) research ideas closer to real-world clinical use. The core purpose is to speed up translation by requiring true, team-based collaboration between clinical and laboratory perspectives, so that discoveries, patient observations, and practical care challenges can inform each other in a back-and-forth way rather than moving in only one direction. Projects are expected to target an SCIRP Area of Encouragement and to tackle questions that would be hard to accomplish through separate, single-lab efforts.
A defining feature of this award is the required partnership structure. Applications must be built around a collaboration of two or three independent investigators (called partners), and the partnership must be both multidisciplinary and multi-institutional. At least two distinct institutions must participate, and the team must include at least one credentialed clinician and at least one partner with experience in SCI laboratory research. The program is explicit that this cannot be a token collaboration: each partner is expected to make substantial intellectual contributions to the project design and execution. Arrangements where one partner mainly provides tissue samples or access to patients, without playing a real scientific role, do not fit the intent of the mechanism. The proposal should clearly show how clinical insight and basic science expertise shape the research plan together, reflecting the program view that translational research is a two-way continuum between bench and bedside.
The TRPA is designed for projects with the potential for major impact, meaning the work should significantly influence concepts or methods in the field and measurably accelerate movement toward clinical application in SCI. The opportunity supports both new and established investigators across many disciplines, and it encourages deliberate involvement of trainees and early-career clinicians or scientists. Importantly, proposals must be grounded in relevant preliminary and/or published data generated by the PI, the research team, or the partners, demonstrating feasibility and a credible starting point rather than a purely speculative concept.
This mechanism does not fund clinical trials. The announcement draws a clear boundary: a clinical trial is defined as prospective accrual of human subjects where an intervention is tested for measurable safety and/or efficacy outcomes, involving informed consent and potentially identifiable information. Applicants aiming to run a rehabilitation-focused clinical trial are directed instead to the SCIRP Clinical Trial Award - Rehabilitation mechanism. In other words, TRPA supports translational research that may inform or prepare for future clinical testing, but it stops short of funding the trial itself.
A notable addition in FY10 is the Nested New Investigator Option, which is meant to build the pipeline of SCI researchers by embedding one mentored trainee or new-to-SCI clinician-scientist within the larger partnership. Only one nested investigator may be included per proposal, and the application must name that person, include their biosketch, and provide a letter describing their goals and commitment to SCI research, along with a mentor support letter. Eligible nested investigators include graduate or medical students, residents, and postdoctoral fellows in mentored training programs, as well as clinicians who are either new to scientific research (no history of independent funding in any discipline) or experienced in research but new to the SCI field (no independent funding or SCI publications). The expectation is that this component offers a real, productive training experience rather than a nominal role.
From the administrative side, this opportunity (Funding Opportunity Number W81XWH-10-SCIRP-TRPA) was posted June 18, 2010, with an original and current closing date of December 1, 2010, and an archive date of December 31, 2010. It is offered as a cooperative agreement/grant within the Science and Technology and other Research and Development category under CFDA 12.420 (Military Medical Research and Development). The estimated total funding listed is $11,250,000 with an expectation of 2 awards, and there is no cost sharing or matching requirement. Eligibility is listed as unrestricted (open to any type of entity), subject to any additional eligibility language in the full announcement. For assistance, the announcement provides program announcement and eReceipt help contacts through CDMRP.
FAQs: DoD Spinal Cord Injury Translational Research Partnership Award (TRPA)
What is the Spinal Cord Injury Translational Research Partnership Award (TRPA)?
The TRPA is a funding opportunity under the Department of Defense (DoD) Spinal Cord Injury Research Program (SCIRP), managed by the U.S. Army Medical Research Acquisition Activity (USAMRAA). Its purpose is to move promising spinal cord injury (SCI) research ideas closer to real-world clinical use by accelerating translation from discovery to practical patient impact.
What is the main goal of this award?
The core goal is to speed up translational SCI research by requiring true, team-based collaboration between clinical and laboratory perspectives. The program emphasizes a two-way flow where lab discoveries and clinical observations inform each other, rather than a one-direction pipeline.
What kind of research does TRPA support?
TRPA supports translational research projects intended to measurably accelerate movement toward clinical application in SCI. Projects should aim for major impact, meaning the work should significantly influence concepts or methods in the field and help move SCI research closer to clinical use.
Does the TRPA require projects to align with specific SCIRP topics?
Yes. Projects are expected to target an SCIRP Area of Encouragement. The opportunity description indicates that proposed work should fit within the SCIRP framework and address questions that would be difficult to accomplish through separate, single-lab efforts.
How many investigators (partners) are required on a TRPA application?
Applications must be built around a partnership of two or three independent investigators (called partners). The award is structured around this required partnership model.
Are there requirements for the partnership structure (multidisciplinary and multi-institutional)?
Yes. The partnership must be both multidisciplinary and multi-institutional. At least two distinct institutions must participate in the proposed work.
Is a clinician required on the team?
Yes. The team must include at least one credentialed clinician as part of the partnership.
Is laboratory SCI research expertise required on the team?
Yes. The team must include at least one partner with experience in SCI laboratory research.
Can a collaboration be based mainly on access to tissue samples or patients?
No. The program explicitly states that token collaborations do not fit the intent of the mechanism. Arrangements where one partner primarily provides tissue samples or patient access without making a substantial intellectual contribution are not consistent with TRPA expectations.
What does the program mean by a "true" partnership?
Each partner is expected to make substantial intellectual contributions to project design and execution. The proposal should clearly demonstrate how clinical insight and basic science expertise jointly shape the research plan, reflecting a two-way bench-to-bedside and bedside-to-bench continuum.
Is the TRPA intended only for new investigators?
No. The opportunity supports both new and established investigators across many disciplines. It also encourages deliberate involvement of trainees and early-career clinicians or scientists.
Is preliminary or published data required?
Yes. Proposals must be grounded in relevant preliminary and/or published data generated by the PI, the research team, or the partners. The intent is to show feasibility and a credible starting point rather than a purely speculative concept.
Does TRPA fund clinical trials?
No. This mechanism does not fund clinical trials. The announcement draws a clear boundary and states that clinical trials are not supported under TRPA.
How does the announcement define a clinical trial for this program?
A clinical trial is defined as prospective accrual of human subjects where an intervention is tested for measurable safety and/or efficacy outcomes, involving informed consent and potentially identifiable information.
If a project is a rehabilitation-focused clinical trial, where should applicants apply instead?
Applicants aiming to run a rehabilitation-focused clinical trial are directed to the SCIRP Clinical Trial Award - Rehabilitation mechanism, rather than TRPA.
What is the Nested New Investigator Option?
The Nested New Investigator Option (noted as a FY10 addition) is intended to build the pipeline of SCI researchers by embedding one mentored trainee or new-to-SCI clinician-scientist within the larger TRPA partnership.
How many nested investigators can be included in a proposal?
Only one nested investigator may be included per proposal.
What documentation is required for a nested investigator?
The application must name the nested investigator, include their biosketch, and provide a letter describing their goals and commitment to SCI research, along with a mentor support letter.
Who is eligible to be a nested investigator under this option?
Eligible nested investigators include graduate or medical students, residents, and postdoctoral fellows in mentored training programs, as well as clinicians who are either (1) new to scientific research (no history of independent funding in any discipline) or (2) experienced in research but new to the SCI field (no independent funding or SCI publications).
What is the expectation for the nested investigator role?
The nested component is expected to provide a real, productive training experience rather than a nominal role on the project.
What is the Funding Opportunity Number (FON) for this award?
The Funding Opportunity Number listed is W81XWH-10-SCIRP-TRPA.
When was this opportunity posted, and what are the key dates?
The opportunity was posted on June 18, 2010. The original and current closing date is December 1, 2010, and the archive date is December 31, 2010.
What type of funding instrument is used?
The opportunity is offered as a cooperative agreement/grant within the Science and Technology and other Research and Development category.
What CFDA number is associated with this opportunity?
The CFDA number listed is 12.420 (Military Medical Research and Development).
How much total funding is estimated, and how many awards are expected?
The estimated total funding listed is $11,250,000, with an expectation of 2 awards.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is listed as unrestricted (open to any type of entity), subject to any additional eligibility language in the full announcement.
Where can applicants get help with the program announcement or submission system?
The announcement references program announcement and eReceipt help contacts through CDMRP for assistance.
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