Opportunity Information: Apply for W81XWH 11 TSCRP EHDA
Apply for W81XWH 11 TSCRP EHDA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Tuberous Sclerosis Complex Exploration Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 28, 2011 and posted on Apr 28, 2011.
- Applicants must submit their applications by Aug 1, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $900,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DOD Tuberous Sclerosis Complex Exploration Hypothesis Development Award is a funding opportunity run through the Department of the Army (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP), specifically within the Tuberous Sclerosis Complex Research Program (TSCRP). TSCRP was created in 2002 with a clear public-health goal: reduce the clinical burden of tuberous sclerosis complex (TSC) by supporting research that deepens understanding of TSC disease mechanisms and moves those insights toward better care for people living with TSC.
This particular award mechanism is built for early-stage, idea-generating science. It targets innovative, high-risk, high-gain projects that may be too preliminary, unconventional, or exploratory for more traditional funding routes. The emphasis is on potentially groundbreaking concepts, including lines of inquiry that come from unexpected or serendipitous observations. Rather than demanding a fully mature hypothesis with extensive supporting evidence, the award is meant to help investigators test feasibility, probe new directions, and generate the kind of initial findings that can either (1) establish a scientific rationale for a brand-new hypothesis or (2) lay down the first principles of an innovative hypothesis that can be developed into larger, follow-on studies.
Preliminary data are welcomed but explicitly not required, which reinforces the program intent to catalyze new thinking instead of rewarding only well-established projects. Even so, applicants are expected to do the heavy lifting in the proposal narrative: the Principal Investigator must clearly and explicitly explain what makes the work innovative and how the core concept is novel in the TSC research landscape. In practice, that means reviewers will be looking for a persuasive case that the project is not just incremental, and that the uncertainty or risk is justified by the potential payoff in knowledge or translational impact.
Administratively, this opportunity was posted April 28, 2011 (Funding Opportunity Number W81XWH-11-TSCRP-EHDA) and originally closed August 1, 2011, with an archive date of August 31, 2011. The funding instrument is listed as a grant and cooperative agreement under a research and development activity category (Science and Technology and other R&D). The program anticipated making about 6 awards, with an estimated total funding pool of $900,000, and it did not require cost sharing or matching. Eligibility was described as unrestricted (open broadly to applicant types), subject to any additional clarifications in the full announcement.
For support with access or submission systems, the announcement directed applicants to the CDMRP Help Desk and PA/eReceipt help lines at 301-682-5507 and help@cdmrp.org.
FAQs: DOD Tuberous Sclerosis Complex Exploration Hypothesis Development Award (TSCRP)
What is this funding opportunity?
The DOD Tuberous Sclerosis Complex Exploration Hypothesis Development Award is a government research funding opportunity offered through the Congressionally Directed Medical Research Programs (CDMRP), within the Tuberous Sclerosis Complex Research Program (TSCRP). It is administered by the Department of the Army (USAMRAA).
Which program is it part of?
This award mechanism is part of the Tuberous Sclerosis Complex Research Program (TSCRP) under CDMRP.
What is the public-health goal of TSCRP?
TSCRP was created in 2002 with the goal of reducing the clinical burden of tuberous sclerosis complex (TSC) by supporting research that improves understanding of TSC disease mechanisms and moves that knowledge toward better care for people living with TSC.
What is the purpose of the Exploration Hypothesis Development Award?
The award is designed to support early-stage, idea-generating research. It aims to help investigators test feasibility, explore new directions, and generate initial findings that can justify or shape a new hypothesis and support follow-on studies.
What types of projects does this award prioritize?
The opportunity emphasizes innovative, high-risk, high-gain projects. It is intended for concepts that may be too preliminary, unconventional, or exploratory for more traditional funding mechanisms, including ideas that arise from unexpected or serendipitous observations.
Does the project need to have a fully developed hypothesis?
No. The mechanism is intended to help establish a scientific rationale for a new hypothesis or to develop the first principles of an innovative hypothesis, rather than requiring a fully mature hypothesis supported by extensive evidence.
Is preliminary data required?
No. Preliminary data are welcomed but explicitly not required, consistent with the intent to catalyze new and exploratory ideas.
If preliminary data are not required, what do reviewers expect to see in the proposal?
Applicants are expected to provide a strong narrative case for why the work is innovative and novel in the TSC research landscape. The Principal Investigator must clearly explain what makes the idea new (not incremental) and why the scientific risk is justified by the potential payoff in knowledge or translational impact.
What makes an application competitive under this mechanism?
Based on the description provided, competitiveness depends on presenting a persuasive innovation argument: a clearly novel core concept for TSC research, a strong rationale for why it could be transformative, and a credible plan to test feasibility or generate the first evidence needed to justify larger future studies.
Who runs and administers this opportunity?
The opportunity is run through the Department of the Army, administered by USAMRAA, and offered under CDMRP.
What is the funding opportunity number?
The Funding Opportunity Number is W81XWH-11-TSCRP-EHDA.
When was the opportunity posted and when did it close?
It was posted on April 28, 2011. It originally closed on August 1, 2011, and the archive date is August 31, 2011.
What type of funding instrument is used?
The funding instrument is listed as a grant and cooperative agreement.
What activity category does it fall under?
It is categorized under research and development activities (Science and Technology and other R&D).
How many awards were anticipated and what was the total funding pool?
The program anticipated making about 6 awards, with an estimated total funding pool of $900,000.
Is cost sharing or matching required?
No. The opportunity indicates that cost sharing or matching was not required.
Who is eligible to apply?
Eligibility was described as unrestricted (open broadly to applicant types), subject to any additional clarifications in the full announcement.
Where can applicants get help with access or submission systems?
The announcement directed applicants to the CDMRP Help Desk and PA/eReceipt help lines at 301-682-5507 and help@cdmrp.org.
What is PA/eReceipt and why is it mentioned?
PA/eReceipt is referenced as part of the support pathway for access or submission systems, and applicants were directed to its help line contact information for assistance.
Is this opportunity still open?
Based on the provided dates (closed August 1, 2011, archived August 31, 2011), it is not open.
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