Opportunity Information: Apply for W81XWH 11 NFRP IIFRA
Apply for W81XWH 11 NFRP IIFRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator Initiated Focused Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 28, 2011 and posted on Apr 28, 2011.
- Applicants must submit their applications by Aug 1, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,100,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Investigator Initiated Focused Research Award (IIFRA) is a Department of Defense grant mechanism under the Neurofibromatosis Research Program (NFRP) intended to support targeted, high-impact studies on neurofibromatosis (NF) and/or schwannomatosis. It funds both basic and clinically oriented research with a clear emphasis on producing meaningful advances: improving scientific understanding of how these diseases develop, driving substantial improvements beyond current methods for diagnosis and treatment, and ultimately improving day-to-day quality of life for people living with NF and schwannomatosis. The program positions the award as a focused research vehicle, meaning proposals are expected to be tightly aligned with specific disease-relevant problems rather than broad exploratory work.
Applications must align with at least one of the program's stated research focus areas as they relate to NF and/or schwannomatosis. These focus areas are pain, wound repair, nerve regeneration, stress and inflammation, and cognitive dysfunction. In practice, this means the project should be framed around one or more of these priority topics and show how the proposed work would address real barriers for patients or clinicians, such as understanding mechanisms that drive chronic pain, improving tissue healing and surgical outcomes, promoting or restoring nerve function, clarifying how inflammatory or stress-related pathways affect disease progression and symptoms, or addressing cognitive and neurological complications that impact functioning and independence.
A key requirement is that the application include preliminary data that is directly relevant to NF and/or schwannomatosis and to the proposed project. This signals that the award is designed for projects with a solid starting foundation and a plausible path to deliverables, rather than early-stage concepts without supporting evidence. Reviewers would reasonably expect the preliminary work to demonstrate feasibility, appropriate model systems or patient cohorts (where applicable), and a clear link between the data and the proposed aims.
While not mandatory, the opportunity strongly encourages collaboration, reflecting an intent to accelerate translation from bench to bedside. The NFRP highlights partnerships between basic scientists and clinical researchers, as well as collaborations between academia and biotechnology or pharmaceutical industry scientists. Collaborations that bring in new disciplines, new technical perspectives, or investigators who are new to the NF field are also explicitly encouraged. This emphasis suggests the program values teams that can bridge mechanistic insights with clinical realities, and that can move discoveries toward practical interventions, diagnostics, or therapeutic strategies.
Administratively, this opportunity (Funding Opportunity Number W81XWH-11-NFRP-IIFRA) was issued by the Department of the Army through USAMRAA, categorized under Science and Technology and other Research and Development, and offered as grants and cooperative agreements. The total estimated funding was $2.1 million with an expectation of making about two awards, indicating a competitive environment and relatively selective funding rates. There is no cost sharing or matching requirement, and eligibility is listed as unrestricted, meaning it is broadly open to various entity types unless further limited by additional eligibility text in the full announcement. The posting date was April 28, 2011, with an application deadline of August 1, 2011, and an archive date of August 31, 2011. For technical access or submission issues, the opportunity points applicants to the CDMRP help resources (PA HELP and eReceipt HELP) via phone and email.
FAQs: DoD Neurofibromatosis Investigator Initiated Focused Research Award (IIFRA)
What is the DoD Neurofibromatosis Investigator Initiated Focused Research Award (IIFRA)?
The IIFRA is a Department of Defense funding mechanism under the Neurofibromatosis Research Program (NFRP) designed to support targeted, high-impact research studies on neurofibromatosis (NF) and/or schwannomatosis.
What kinds of research does this award support?
The award supports both basic and clinically oriented research, as long as the work is tightly focused on NF and/or schwannomatosis and aims to produce meaningful advances beyond current approaches to understanding, diagnosis, or treatment.
What is the main goal of the IIFRA program?
The program emphasizes projects that can improve scientific understanding of disease development, lead to substantial improvements in diagnosis and treatment, and ultimately improve day-to-day quality of life for people living with NF and schwannomatosis.
What does it mean that this is a "focused research" award?
It means proposals are expected to be tightly aligned with specific disease-relevant problems rather than broad, exploratory, or highly speculative work. The project should be framed around a defined problem and a clear path to impactful outcomes.
Do applications have to fit specific research focus areas?
Yes. Applications must align with at least one of the program's stated research focus areas as they relate to NF and/or schwannomatosis.
What are the stated research focus areas for this opportunity?
The focus areas are: pain, wound repair, nerve regeneration, stress and inflammation, and cognitive dysfunction.
Can a project address more than one focus area?
The opportunity states that applications must align with at least one focus area. Based on that wording, a project may be framed around one or more of the listed priorities as long as the alignment is clear and disease-relevant.
What types of patient or clinical barriers is the program trying to address?
The description highlights real barriers such as understanding mechanisms that drive chronic pain, improving tissue healing and surgical outcomes, promoting or restoring nerve function, clarifying how stress-related or inflammatory pathways affect disease progression and symptoms, and addressing cognitive and neurological complications that impact functioning and independence.
Is preliminary data required?
Yes. A key requirement is that the application include preliminary data directly relevant to NF and/or schwannomatosis and directly relevant to the proposed project.
How closely must preliminary data relate to the proposed project?
The preliminary data must be directly relevant both to NF and/or schwannomatosis and to the proposed project, indicating reviewers will expect a clear connection between the data and the proposed aims.
What is the purpose of requiring preliminary data?
The requirement signals that the award is intended for projects with a solid starting foundation and a plausible path to deliverables, rather than early-stage concepts without supporting evidence.
Is collaboration required to apply?
No. Collaboration is not mandatory, but it is strongly encouraged.
What types of collaborations are encouraged?
The NFRP highlights partnerships between basic scientists and clinical researchers, collaborations between academia and biotechnology or pharmaceutical industry scientists, and collaborations that bring in new disciplines, new technical perspectives, or investigators who are new to the NF field.
Why does the opportunity encourage collaboration?
The stated intent is to accelerate translation from bench to bedside and to support teams that can connect mechanistic insights with clinical realities and move discoveries toward practical interventions, diagnostics, or therapeutic strategies.
Who is the issuing agency for this funding opportunity?
The opportunity was issued by the Department of the Army through USAMRAA.
What is the Funding Opportunity Number (FON) for this award?
The Funding Opportunity Number is W81XWH-11-NFRP-IIFRA.
How is this opportunity categorized?
It is categorized under Science and Technology and other Research and Development.
What funding instrument types are used for this opportunity?
The opportunity is offered as grants and cooperative agreements.
How much total funding was estimated for this opportunity?
The total estimated funding was $2.1 million.
About how many awards were expected to be made?
The program expected to make about two awards.
What does the expected number of awards suggest about competitiveness?
With an estimated $2.1 million total funding and about two expected awards, the opportunity appears relatively selective and competitive.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is broadly open to various entity types unless additional eligibility limitations exist in the full announcement.
When was this opportunity posted?
The posting date was April 28, 2011.
What was the application deadline?
The application deadline was August 1, 2011.
When was the opportunity archived?
The archive date was August 31, 2011.
Where can applicants get help with technical access or submission issues?
The opportunity directs applicants to CDMRP help resources (PA HELP and eReceipt HELP) and notes that assistance is available via phone and email.
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