Opportunity Information: Apply for W81XWH 11 NFRP IIRA
Apply for W81XWH 11 NFRP IIRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 28, 2011 and posted on Apr 28, 2011.
- Applicants must submit their applications by Aug 1, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,100,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA) is a long-running funding mechanism designed to support both basic and clinically oriented studies that can move the field forward in meaningful ways for people living with neurofibromatosis (NF) and schwannomatosis. First offered in FY1996, this award track has a clear history of competitive demand and selective funding: 341 applications had been received across prior cycles, with 96 recommended for funding. The central aim is to back investigator-driven ideas that deepen scientific understanding of how these diseases develop, lead to major improvements in diagnosis and treatment beyond current standards, and ultimately produce tangible quality-of-life benefits for patients.
For the FY2011 cycle, the program highlights several priority needs where the NF community sees urgent gaps. One emphasis is on serious complications associated with high mortality, including tumors (neoplasms) and cerebrovascular abnormalities. Another focus is on complications that may not be as immediately life-threatening but can cause substantial long-term burden and disability, such as skeletal problems, learning deficits, hormone-associated effects, and pain. The announcement also encourages work that helps the field get better at measuring disease and treatment response, specifically through refining and standardizing imaging techniques, molecular and cellular markers, and quality-of-life metrics that can be used reliably in future clinical trials. In addition, there is a strong translational push, including the development of new therapeutic strategies and preclinical testing of candidate agents intended to treat NF.
A key requirement is that applications include preliminary data directly relevant to NF and/or schwannomatosis and to the proposed research plan, signaling that the program expects projects to be grounded in evidence rather than purely exploratory concepts. While not mandatory, the opportunity explicitly supports an optional qualified collaborator component, with a strong preference for collaborative approaches that bridge basic science and clinical research, connect academia with biotechnology or pharmaceutical partners, or bring in new perspectives from outside the traditional NF research space. This includes collaborations that may attract new investigators into the NF field, which the program views as a way to accelerate innovation.
Administratively, this opportunity was posted April 28, 2011, and closed August 1, 2011 (archived August 31, 2011). It was offered by the Department of the Army through USAMRAA under the broader category of military medical research and development (CFDA 12.420). The funding instrument type listed includes cooperative agreements and grants, with an estimated total program funding level of $2.1 million and an anticipated two awards. Eligibility is described as unrestricted, meaning it is broadly open to applicant organizations, and there is no cost-sharing or matching requirement. For applicants needing technical assistance with the electronic submission or announcement access, the opportunity provides help desk contacts through CDMRP/PA and eReceipt support.
FAQs: DoD Neurofibromatosis Research Program (NFRP) Investigator Initiated Research Award (IIRA) - FY2011
What is the NFRP Investigator Initiated Research Award (IIRA)?
The Investigator Initiated Research Award (IIRA) is a long-running funding mechanism under the DoD Neurofibromatosis Research Program (NFRP) designed to support investigator-driven research in neurofibromatosis (NF) and schwannomatosis. It supports both basic and clinically oriented studies intended to move the field forward in meaningful ways for people living with NF and schwannomatosis.
What is the main goal of this award?
The central aim is to fund research ideas that (1) deepen scientific understanding of how NF and schwannomatosis develop, (2) lead to major improvements in diagnosis and treatment beyond current standards, and (3) ultimately produce tangible quality-of-life benefits for patients.
When was this award mechanism first offered?
This award track was first offered in FY1996.
How competitive is this funding opportunity based on prior cycles?
The opportunity has a history of competitive demand and selective funding. Across prior cycles, 341 applications were received and 96 were recommended for funding.
What research areas are emphasized as priority needs for the FY2011 cycle?
For FY2011, the program highlights several urgent gaps identified by the NF community, including:
- Serious complications with high mortality, including tumors (neoplasms) and cerebrovascular abnormalities
- Complications causing substantial long-term burden and disability, such as skeletal problems, learning deficits, hormone-associated effects, and pain
- Work that improves measurement of disease and treatment response, including refining and standardizing imaging techniques, molecular and cellular markers, and quality-of-life metrics suitable for future clinical trials
- Translational research such as developing new therapeutic strategies and conducting preclinical testing of candidate agents intended to treat NF
Does the program support both basic and clinical research?
Yes. The IIRA is designed to support both basic studies and clinically oriented studies, including work that bridges basic science and clinical research.
Is translational research encouraged?
Yes. The announcement includes a strong translational push, including developing new therapeutic strategies and preclinical testing of candidate agents intended to treat NF.
Are projects expected to include preliminary data?
Yes. A key requirement is that applications include preliminary data directly relevant to NF and/or schwannomatosis and to the proposed research plan. This indicates the program expects projects to be grounded in evidence rather than purely exploratory concepts.
Is collaboration required to apply?
No. Collaboration is not mandatory, but the opportunity explicitly supports an optional qualified collaborator component.
What types of collaborations are preferred?
The program expresses a strong preference for collaborative approaches, including collaborations that:
- Bridge basic science and clinical research
- Connect academia with biotechnology or pharmaceutical partners
- Bring in new perspectives from outside the traditional NF research space
- Help attract new investigators into the NF field to accelerate innovation
Who posted this funding opportunity and under what program category?
This opportunity was offered by the Department of the Army through USAMRAA under the broader category of military medical research and development.
What is the CFDA number associated with this opportunity?
The CFDA number listed for this opportunity is 12.420.
What funding instrument types are used for this opportunity?
The funding instrument type listed includes cooperative agreements and grants.
How much total funding was estimated for the FY2011 program, and how many awards were anticipated?
The estimated total program funding level was $2.1 million, with an anticipated two awards.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to applicant organizations.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
When did the FY2011 opportunity open and close?
The opportunity was posted on April 28, 2011, and closed on August 1, 2011. It was archived on August 31, 2011.
Where can applicants get technical help with electronic submission?
The opportunity provides help desk contacts through CDMRP/PA and eReceipt support for applicants needing technical assistance with electronic submission or accessing the announcement.
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