DOD Tuberous Sclerosis Complex Idea Development Award | Apply Online

Opportunity Summary:

The DOD Tuberous Sclerosis Complex (TSC) Idea Development Award is a Department of Defense funding opportunity offered through the Tuberous Sclerosis Complex Research Program (TSCRP), which was created in 2002 to support research that reduces the clinical burden of TSC. The program is centered on improving understanding of TSC disease mechanisms (pathogenesis) and translating those insights into better approaches to care for people living with TSC. For the FY11 cycle, this award is positioned as a driver for bold, field-shaping research rather than routine or incremental work.

The core purpose of the Idea Development Award is to fund high-impact, innovative projects that can move TSC research forward in a meaningful way. The announcement emphasizes that proposed studies should be original and capable of changing the concepts, methods, or overall direction of TSC research. Innovation is defined broadly: it can come from introducing a new scientific paradigm, challenging widely held assumptions, reframing a long-standing problem from a different angle, or applying uniquely creative approaches. Innovation can also be reflected in the study concept, the research tools or technologies used, the design of clinical interventions (as concepts, not as formal trials), or the adaptation of existing methods and technologies to TSC in a genuinely new way. In contrast, projects that primarily extend previously published findings in a stepwise or incremental manner are explicitly discouraged and may be considered non-responsive to the intent of the mechanism.

In terms of the types of work supported, preclinical research is encouraged, which signals openness to laboratory studies, animal models, mechanistic experiments, biomarker development, and other translationally oriented efforts that are not human clinical trials. At the same time, clinical trials are not permitted under this award, so applicants need to shape any human-related research accordingly (for example, focusing on observational, mechanistic, or preparatory work rather than interventional trials). Another key expectation is that applicants include preliminary data that directly supports the feasibility and rationale of the proposed project, indicating that while the program seeks creative ideas, it also expects evidence that the idea can be executed and is grounded in credible early findings.

Collaboration is highlighted as a major priority for this funding opportunity. The FY11 TSCRP particularly encourages partnerships between basic scientists and clinical researchers to strengthen translation from mechanism to patient relevance. It also welcomes collaborations between academic investigators and biotechnology or pharmaceutical industry scientists, reflecting an interest in accelerating the pathway from discovery to practical application. The program further notes that collaborations bringing in new disciplines or attracting new investigators into the TSC research space are strongly encouraged, suggesting that cross-pollination from adjacent fields and fresh perspectives are viewed as a way to catalyze breakthroughs.

Administratively, this opportunity was issued by the Department of the Army (USAMRAA) under Funding Opportunity Number W81XWH-11-TSCRP-IDA. The funding instrument type is listed as a cooperative agreement and grant, and it falls under the Science and Technology and other Research and Development category (CFDA 12.420, Military Medical Research and Development). The program anticipated making about three awards, with an estimated total funding level of $2.7 million. Cost sharing or matching is not required. Eligibility is described as unrestricted, meaning a wide range of entity types can apply, subject to any additional eligibility clarifications contained in the full announcement. Key dates for the archived FY11 cycle include a posting date of April 28, 2011, an original and final closing date of August 1, 2011, and an archive date of August 31, 2011. For technical assistance with accessing the full announcement or submission systems, the notice points applicants to the CDMRP help resources (PA HELP and eReceipt HELP) via phone at 301-682-5507 or email at help@cdmrp.org.

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