Opportunity Information: Apply for PA 15 081

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Drug Abuse Prevention Intervention Research (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Jan 9, 2015 and posted on Jan 9, 2015.
  • Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $50,000.00 in funding.
  • Eligible applicants include: For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Special district governments Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Others (see text field entitled Additional Information on Eligibility for clarification).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Drug Abuse Prevention Intervention Research (R03) opportunity (Funding Opportunity Number PA 15 081) was a National Institutes of Health (NIH) discretionary grant program designed to support small, focused research projects that strengthen the evidence base for drug use prevention. It called for studies that use rigorous scientific methods to test theoretically grounded hypotheses, with the overall goal of improving understanding of how drug use prevention works across different populations, settings, and stages of life. In practical terms, this FOA was looking for projects that do more than describe risk or protective factors; it emphasized well-justified research questions and credible study designs that can clarify mechanisms and inform prevention practice.

A central theme of the announcement was prevention science across the lifespan and in diverse real-world contexts. Applicants were encouraged to examine cognitive, behavioral, and social processes that shape substance use initiation, escalation, and avoidance, and to connect those processes to prevention strategies that can be implemented in families, schools, healthcare settings, workplaces, justice-related settings, or communities. The FOA emphasized diversity in populations and contexts, signaling interest in prevention research that is relevant to varied cultural, socioeconomic, geographic, and developmental circumstances rather than one-size-fits-all approaches.

The FOA highlighted four broad, overlapping areas of interest. First, it encouraged the development of novel prevention approaches, meaning new intervention concepts, components, or strategies that are grounded in theory and informed by prior evidence. Second, it supported research on the efficacy and effectiveness of prevention interventions or programs, which can include testing whether an intervention works under controlled conditions (efficacy) and whether it works in typical practice settings (effectiveness). Third, it encouraged studies on how to optimize the selection, integration, implementation, and sustainability of science-based prevention, including systems-level factors (such as organizational readiness, workforce capacity, interagency coordination, policy environment) and health economic considerations (such as cost, cost-effectiveness, and resource allocation). Fourth, it welcomed methodological work suited to studying complex prevention questions, which can include designs and analytic approaches appropriate for multi-level interventions, dynamic processes over time, implementation complexity, and heterogeneous effects across subgroups or settings.

As an R03 mechanism, the program was oriented toward smaller-scale projects that can produce clear, useful answers without requiring the size and budget of larger clinical trials. The listed award ceiling was $50,000, and the FOA specified that there was no cost-sharing or matching requirement. The catalog listing associated with this opportunity was CFDA 93.279 (Drug Abuse and Addiction Research Programs), placing it within NIH's broader portfolio of substance use and addiction research.

Eligibility was broad and included many types of domestic and non-domestic organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities/Indian housing authorities, Native American tribal governments (federally recognized) and other tribal organizations, and additional categories such as faith-based or community-based organizations. The eligibility information also explicitly referenced institutions and organizations serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISIs, as well as U.S. territories or possessions, regional organizations, foreign (non-U.S.) entities, and eligible federal agencies.

Timeline-wise, the opportunity was posted and created on January 9, 2015, with an original and current closing date of September 7, 2017, and an archive date of October 8, 2017, indicating it is no longer open. Applicants and interested parties were directed to the full FOA text on the NIH Grants Guide website (http://grants.nih.gov/grants/guide/pa-files/PA-15-081.html). For technical issues accessing the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: Drug Abuse Prevention Intervention Research (R03) - PA-15-081

What is the Drug Abuse Prevention Intervention Research (R03) opportunity (PA-15-081)?

PA-15-081 was a National Institutes of Health (NIH) discretionary grant program that supported small, focused research projects intended to strengthen the evidence base for drug use prevention.

What was the main goal of this funding opportunity?

The overall goal was to improve understanding of how drug use prevention works across different populations, settings, and stages of life, using rigorous scientific methods to test theoretically grounded hypotheses.

What kind of projects did the FOA emphasize?

The FOA emphasized projects with well-justified research questions and credible study designs that can clarify mechanisms of prevention and inform prevention practice, rather than projects that only describe risk or protective factors.

What does "prevention science across the lifespan" mean in this FOA?

It refers to prevention research that considers different stages of life and how cognitive, behavioral, and social processes shape substance use initiation, escalation, and avoidance over time, and how prevention may work differently at different developmental stages.

Did the FOA encourage studies in real-world settings?

Yes. The announcement encouraged work in diverse real-world contexts and settings where prevention strategies may be implemented, rather than limiting research to highly controlled environments only.

Which settings were specifically mentioned as relevant contexts for prevention strategies?

The FOA referenced families, schools, healthcare settings, workplaces, justice-related settings, and communities as examples of contexts where prevention strategies could be implemented and studied.

Was diversity in populations and contexts a priority?

Yes. The FOA emphasized interest in prevention research relevant to varied cultural, socioeconomic, geographic, and developmental circumstances, rather than one-size-fits-all approaches.

What research topics or areas of interest did the FOA highlight?

The FOA highlighted four broad, overlapping areas of interest: (1) development of novel prevention approaches, (2) efficacy and effectiveness research for prevention interventions/programs, (3) optimization of selection, integration, implementation, and sustainability of science-based prevention (including systems-level and economic considerations), and (4) methodological work suited to complex prevention questions.

What does the FOA mean by "novel prevention approaches"?

It refers to new intervention concepts, components, or strategies that are grounded in theory and informed by prior evidence.

What is the difference between efficacy and effectiveness in this announcement?

The FOA described efficacy as testing whether an intervention works under controlled conditions, and effectiveness as testing whether it works in typical practice settings.

What kinds of implementation and sustainability issues were of interest?

The FOA welcomed studies on how to optimize selection, integration, implementation, and sustainability of science-based prevention, including systems-level factors such as organizational readiness, workforce capacity, interagency coordination, and the policy environment.

Did the FOA allow or encourage health economic considerations?

Yes. It explicitly included health economic considerations such as cost, cost-effectiveness, and resource allocation as relevant to optimizing prevention.

What kinds of methodological research were welcomed?

The FOA welcomed designs and analytic approaches appropriate for multi-level interventions, dynamic processes over time, implementation complexity, and heterogeneous effects across subgroups or settings.

What does the R03 mechanism imply about project scale?

As an R03 mechanism, it was oriented toward smaller-scale projects intended to produce clear, useful answers without requiring the size and budget of larger clinical trials.

What was the maximum award amount listed for this opportunity?

The listed award ceiling was $50,000.

Was cost-sharing or matching required?

No. The FOA specified there was no cost-sharing or matching requirement.

What CFDA number was associated with this opportunity?

The catalog listing associated with this opportunity was CFDA 93.279, labeled "Drug Abuse and Addiction Research Programs."

Who was eligible to apply?

Eligibility was broad and included many types of domestic and non-domestic organizations, including higher education institutions, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple government entity types.

Which types of U.S. government entities were listed as eligible?

The FOA listed state and local governments (including county and city/township governments), independent school districts, special district governments, and public housing authorities/Indian housing authorities.

Were tribal governments and tribal organizations eligible?

Yes. The eligibility list included Native American tribal governments (federally recognized) and other tribal organizations.

Were faith-based or community-based organizations eligible?

Yes. The eligibility information included categories such as faith-based or community-based organizations.

Did the FOA reference institutions serving specific populations?

Yes. It explicitly referenced institutions and organizations serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISIs.

Could foreign (non-U.S.) entities apply?

Yes. The eligibility information included foreign (non-U.S.) entities.

Were U.S. territories or possessions included in eligibility?

Yes. The eligibility information referenced U.S. territories or possessions.

Were eligible federal agencies included?

Yes. The eligibility information included eligible federal agencies.

When was this opportunity posted and created?

It was posted and created on January 9, 2015.

What was the closing date for applications?

The original and current closing date listed was September 7, 2017.

Is this funding opportunity still open?

No. The archive date was October 8, 2017, indicating the opportunity is no longer open.

Where could applicants find the full FOA text?

The full FOA text was available on the NIH Grants Guide website at http://grants.nih.gov/grants/guide/pa-files/PA-15-081.html.

Who was the contact for technical issues accessing the announcement?

For technical issues accessing the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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