Opportunity Information: Apply for PA 15 080

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Drug Abuse Prevention Intervention Research (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Jan 9, 2015 and posted on Jan 9, 2015.
  • Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Drug Abuse Prevention Intervention Research (R21) opportunity (Funding Opportunity Number PA-15-080) is a National Institutes of Health (NIH) discretionary grant program designed to support early-stage, exploratory research that strengthens the scientific foundation of drug use prevention. It uses the NIH R21 mechanism, which is typically meant for projects that are innovative, potentially high-impact, and may be at an earlier phase of development than a full-scale clinical or community trial. The central goal is to fund studies that apply rigorous scientific methods to test theoretically grounded hypotheses, with the broader aim of improving how prevention science understands, designs, and delivers interventions that reduce drug use and related harms. A key emphasis is on relevance across the lifespan and across diverse populations and real-world settings, rather than focusing narrowly on one age group or one type of community.

The FOA is especially interested in research that examines cognitive, behavioral, and social processes that influence substance use risk and protection, and then uses that knowledge to build or refine prevention strategies. The announcement highlights four main areas of interest. First, it encourages the development of novel prevention approaches, meaning new or meaningfully improved strategies that are driven by theory and evidence about how drug use begins and escalates. Second, it supports studies that test the efficacy and effectiveness of prevention interventions or programs, which can include controlled tests of whether an intervention works under ideal conditions (efficacy) and whether it works in typical community or service environments (effectiveness). Third, it invites research on how to optimize the selection, integration, implementation, and sustainability of science-based prevention, including systems-level influences and health economic factors. In practice, this means projects that look at how prevention programs are chosen, adopted, delivered with quality, adapted responsibly, financed, and maintained over time in settings like schools, clinics, justice systems, social services, or community organizations. Fourth, it encourages methodological work suited to the complexity of prevention science, which can include improved designs, measures, analytic strategies, or other methods needed to study multilevel and real-world prevention challenges.

From an administrative standpoint, this is a grant opportunity categorized under Education and Health, tied to CFDA number 93.279 (Drug Abuse and Addiction Research Programs). The award ceiling listed is $200,000, and there is no cost sharing or matching requirement. The opportunity was posted and created on January 9, 2015, with an original and current closing date of September 7, 2017, and an archive date of October 8, 2017, meaning it is no longer open under those dates but remains useful as a reference for the kind of prevention intervention research NIH has sought through this program.

Eligibility is broad and includes many types of organizations that might contribute to prevention research. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public and private institutions of higher education. Various nonprofit organizations are eligible, including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status, and public housing authorities and Indian housing authorities are also listed. The FOA allows applications from for-profit organizations (other than small businesses) and from small businesses as well. It explicitly includes tribal governments (federally recognized) and other tribal organizations, as well as tribally controlled colleges and universities. It also extends eligibility to a range of mission-focused institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs). Faith-based and community-based organizations may apply, and importantly, non-U.S. entities and foreign institutions are eligible, including foreign components as permitted under NIH policy, as well as non-U.S. components of U.S. organizations.

For applicants looking for official details, the full announcement was hosted on the NIH grants website at http://grants.nih.gov/grants/guide/pa-files/PA-15-080.html. The contact listed for access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the Drug Abuse Prevention Intervention Research (R21) opportunity?

This opportunity is an NIH discretionary grant program titled Drug Abuse Prevention Intervention Research (R21), under Funding Opportunity Number (FON) PA-15-080. It supports early-stage, exploratory research intended to strengthen the scientific foundation of drug use prevention.

What NIH grant mechanism does this program use?

The program uses the NIH R21 mechanism, which is generally used for innovative, potentially high-impact projects that may be at an earlier stage than a full-scale clinical or community trial.

What is the central goal of this funding opportunity?

The central goal is to fund studies that use rigorous scientific methods to test theoretically grounded hypotheses, with the broader aim of improving how prevention science understands, designs, and delivers interventions that reduce drug use and related harms.

Is the program focused on a particular age group or community type?

No. A key emphasis is relevance across the lifespan and across diverse populations and real-world settings, rather than a narrow focus on one age group or one type of community.

What kinds of scientific topics are emphasized?

The FOA emphasizes research that examines cognitive, behavioral, and social processes that influence substance use risk and protection, and then uses that knowledge to build or refine prevention strategies.

What are the main research areas of interest in PA-15-080?

The announcement highlights four main areas of interest: (1) development of novel prevention approaches; (2) studies testing efficacy and effectiveness of prevention interventions or programs; (3) research on optimizing selection, integration, implementation, and sustainability of science-based prevention (including systems-level and health economic factors); and (4) methodological work suited to the complexity of prevention science.

What does "development of novel prevention approaches" mean in this FOA?

It refers to new or meaningfully improved prevention strategies that are driven by theory and evidence about how drug use begins and escalates.

What is the difference between efficacy and effectiveness studies as described here?

Efficacy studies assess whether an intervention works under ideal or controlled conditions, while effectiveness studies assess whether it works in typical community or service environments.

What kinds of settings does the FOA consider for implementation and sustainability research?

The FOA points to real-world settings such as schools, clinics, justice systems, social services, and community organizations as examples of where prevention programs may be chosen, adopted, delivered, adapted, financed, and maintained over time.

What does the FOA mean by optimizing selection, integration, implementation, and sustainability?

This includes studying how science-based prevention programs are selected and integrated into systems, implemented with quality, adapted responsibly, financed, and sustained, including the influence of systems-level factors and health economic considerations.

What types of methodological work are encouraged?

The FOA encourages methodological work that fits prevention science complexity, including improved study designs, measures, analytic strategies, and other methods needed to address multilevel and real-world prevention challenges.

How is this opportunity categorized for administrative purposes?

It is categorized under Education and Health and tied to CFDA number 93.279 (Drug Abuse and Addiction Research Programs).

What is the award ceiling for this opportunity?

The listed award ceiling is $200,000.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

When was the opportunity posted and when did it close?

It was posted and created on January 9, 2015. The original and current closing date listed is September 7, 2017, with an archive date of October 8, 2017.

Is this funding opportunity still open?

No. Based on the closing and archive dates provided (closing date September 7, 2017; archive date October 8, 2017), it is no longer open under those dates, but it remains useful as a reference for the type of prevention intervention research NIH has sought through the program.

Who is eligible to apply?

Eligibility is broad and includes: state, county, city, or township governments; special district governments; independent school districts; public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status); public housing authorities and Indian housing authorities; for-profit organizations (other than small businesses); small businesses; tribal governments (federally recognized) and other tribal organizations; and tribally controlled colleges and universities.

Are minority-serving institutions included in eligibility?

Yes. The FOA explicitly includes eligibility for institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).

Can faith-based or community-based organizations apply?

Yes. The FOA states that faith-based and community-based organizations may apply.

Are non-U.S. or foreign organizations eligible?

Yes. The FOA indicates that non-U.S. entities and foreign institutions are eligible, including foreign components as permitted under NIH policy, as well as non-U.S. components of U.S. organizations.

Where can applicants find the official announcement?

The full announcement was hosted on the NIH grants website at: http://grants.nih.gov/grants/guide/pa-files/PA-15-080.html

Who is the contact for access or linking issues related to the announcement?

The listed contact for access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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