Opportunity Information: Apply for PAR 13 350

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) (R21/R33)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Sep 11, 2013 and posted on Sep 11, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments Private institutions of higher education County governments Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) (R21/R33), Funding Opportunity Number PAR-13-350, is a National Institutes of Health (NIH) discretionary grant program designed to help investigators who are new to NIH funding establish themselves in basic chemistry research that is directly relevant to drug abuse and addiction. The central purpose of the announcement is to lower the barrier for early-stage or otherwise NIH-new researchers to enter this space by supporting exploratory, chemistry-driven ideas that can mature into more developed projects with clear relevance to substances of abuse, addiction mechanisms, or addiction-related health outcomes. In practical terms, the program is aimed at bringing fresh chemistry expertise and innovative chemical thinking into addiction research, encouraging new investigators to apply modern chemical approaches to problems that matter to the drug abuse and addiction field.

This FOA uses a phased award structure, combining an R21 and an R33 into a single opportunity. The R21 phase is typically used for early, high-impact exploratory work where feasibility, proof-of-concept, or initial tool development is the focus. If the project meets the defined milestones and shows sufficient progress, it can transition into the R33 phase, which is generally intended for expanded development, validation, and more substantial advancement of the initial chemistry concept. This structure is particularly helpful for chemistry-focused projects where early experimental uncertainty is common, and where a smaller, flexible first phase can de-risk an idea before moving into a more robust second phase.

The activity categories listed for the opportunity are Education and Health, and the associated CFDA number is 93.279 (Drug Abuse and Addiction Research Programs). There is no cost sharing or matching requirement, which means applicants are not expected to commit institutional matching funds as a condition of the award. The award ceiling shown in the provided data is $250,000, signaling that the opportunity is intended to fund relatively focused early-career projects rather than large, multi-component efforts.

Eligibility is broad and includes many types of applicant organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profit entities), and various government entities such as state, county, city or township governments, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal governments and tribal organizations, including Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments), as well as tribally controlled colleges and universities (TCCUs). In addition, the eligibility language encompasses a range of designated institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations, regional organizations, and eligible federal agencies. Importantly, non-U.S. entities are also eligible: foreign organizations and foreign institutions may apply, non-domestic components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are allowed, which makes this opportunity accessible to qualified international applicants and collaborations where permitted under NIH rules.

From a timing and administrative standpoint, the FOA was posted and created on September 11, 2013. The original closing date and the current closing date listed are both September 7, 2016, and the archive date is October 8, 2016. That means this particular announcement is no longer active as a current funding opportunity, but it remains useful as a reference point for understanding NIH priorities and the design of early-career mechanisms in this research area, and it can help prospective applicants anticipate what similar future announcements might look like.

For official source material, NIH provided an additional information link to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-13-350.html. The contact details included are primarily for technical access or linking issues, directing applicants to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which indicates the contact provided is oriented toward resolving electronic access problems rather than providing scientific or programmatic guidance.

Overall, ECHEM (R21/R33) is best understood as an NIH effort to seed the field with new investigators who bring strong chemistry ideas to addiction science, using a milestone-driven, two-stage grant structure that supports early exploration followed by growth into a more mature line of work, while keeping eligibility wide across academic, nonprofit, for-profit, governmental, tribal, and international organizations.

Frequently Asked Questions (FAQs)

What is the ECHEM (R21/R33) grant opportunity?

The Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) is an NIH discretionary grant program that supports basic chemistry research directly relevant to drug abuse and addiction. It is designed to help investigators who are new to NIH funding establish themselves in this area.

What is the Funding Opportunity Number (FOA number) for this program?

The Funding Opportunity Number is PAR-13-350.

What types of research does this program support?

The program supports chemistry-driven basic research that is directly relevant to drug abuse and addiction. The intent is to bring modern chemical approaches and innovative chemistry expertise to problems tied to substances of abuse, addiction mechanisms, or addiction-related health outcomes.

Who is this program primarily meant to help?

It is aimed at investigators who are new to NIH funding, particularly those early in their careers or otherwise NIH-new, to lower the barrier to entering addiction-relevant chemistry research.

What is the main purpose of the announcement?

The central purpose is to lower entry barriers for early-stage or NIH-new researchers by funding exploratory chemistry ideas that can grow into more developed projects with clear relevance to drug abuse and addiction.

How is the award structured?

This FOA uses a phased award structure that combines an R21 phase and an R33 phase into a single opportunity.

What is the R21 phase intended to support?

The R21 phase is typically used for early, high-impact exploratory work, such as feasibility studies, proof-of-concept efforts, or initial tool development.

What triggers the transition from the R21 phase to the R33 phase?

Transition to the R33 phase is intended to occur if the project meets defined milestones and demonstrates sufficient progress during the R21 phase.

What is the R33 phase intended to support?

The R33 phase is generally intended for expanded development, validation, and more substantial advancement of the initial chemistry concept established in the R21 phase.

Why use a phased R21/R33 structure for chemistry-driven projects?

The phased approach is described as helpful for chemistry-focused projects where early experimental uncertainty is common. The smaller, flexible first phase can help de-risk an idea before moving into a more robust second phase.

What are the activity categories associated with this opportunity?

The listed activity categories are Education and Health.

What is the CFDA number for this program?

The associated CFDA number is 93.279 (Drug Abuse and Addiction Research Programs).

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

What is the award ceiling listed for this opportunity?

The award ceiling shown in the provided data is $250,000.

What does the $250,000 ceiling suggest about the scope of projects?

It suggests the opportunity is intended to fund relatively focused early-career projects rather than large, multi-component efforts.

Which organizations are eligible to apply?

Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profit entities), and various government entities.

What types of government entities are included in eligibility?

Eligible government entities include state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities.

Are tribal governments and tribal organizations eligible?

Yes. The FOA explicitly includes Native American tribal governments (federally recognized), Native American tribal organizations (other than federally recognized tribal governments), and tribally controlled colleges and universities (TCCUs).

Are certain institution types specifically mentioned as eligible?

Yes. The eligibility language includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based and community-based organizations are included among eligible applicants.

Are regional organizations eligible?

Yes. Regional organizations are included in the eligibility language.

Are federal agencies eligible to apply?

Yes. Eligible federal agencies are included among eligible applicants.

Can non-U.S. organizations apply?

Yes. Foreign organizations and foreign institutions may apply.

Are non-domestic components of U.S. organizations eligible?

Yes. Non-domestic components of U.S. organizations are eligible.

Are foreign components allowed under this FOA?

Yes. Foreign components (as defined in NIH policy) are allowed.

When was this FOA posted and created?

The FOA was posted and created on September 11, 2013.

What were the closing date(s) for this opportunity?

The original closing date and the current closing date listed are both September 7, 2016.

What is the archive date for this FOA?

The archive date is October 8, 2016.

Is this funding opportunity currently active?

No. Based on the listed closing date (September 7, 2016) and archive date (October 8, 2016), this specific announcement is no longer active.

Does the FOA still have value if it is archived?

Yes. It can still be useful as a reference for understanding NIH priorities and how early-career mechanisms in chemistry and addiction research may be designed, which may help applicants anticipate what similar future announcements could look like.

Where can I find the official NIH announcement text?

The additional information link provided by NIH is: http://grants.nih.gov/grants/guide/pa-files/PAR-13-350.html.

Who is listed as the contact for this opportunity?

The contact details provided are for technical access or linking issues, directing users to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

What kind of help is the listed contact most suited for?

The provided contact appears oriented toward resolving electronic access problems (such as technical access or linking issues) rather than offering scientific or programmatic guidance.

In one sentence, how should ECHEM be understood overall?

It is an NIH effort to seed addiction science with new NIH-funded investigators who bring strong, innovative chemistry ideas, using a milestone-driven two-stage R21/R33 structure and broad organizational eligibility, including international participation where permitted under NIH rules.

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