Opportunity Information: Apply for PAR 13 351

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIGMS National Centers for Systems Biology (P50)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
  • This funding opportunity was created on Jun 30, 2014 and posted on Sep 11, 2013.
  • Applicants must submit their applications by Jun 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Special district governments For profit organizations other than small businesses City or township governments Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The NIGMS National Centers for Systems Biology (P50) opportunity (Funding Opportunity Number PAR-13-351) is a National Institutes of Health discretionary grant program designed to create or support Centers of Excellence in Systems Biology. The central purpose is to stimulate ambitious, systems-level research that helps explain biomedical phenomena through integrated, quantitative, and often interdisciplinary approaches, while also building strong environments for research training and outreach. In practice, this means NIGMS is looking for center-style applications that go beyond a single project or lab, bringing together multiple investigators and complementary capabilities to tackle complex biological questions aligned with the NIGMS mission, which broadly emphasizes fundamental, generalizable mechanisms in biology that underpin advances in medicine.

This opportunity uses the NIH P50 Center Grant mechanism, which typically supports a coordinated program with multiple interrelated research components and shared resources. The emphasis in the announcement is not only on pioneering research, but also on developing research training activities and outreach programs as part of the center concept, signaling that applicants should plan for both scientific output and workforce or community impact. The funding activity category is Health, and the CFDA listing is 93.859 (Biomedical Research and Research Training), reflecting the dual focus on discovery science and training.

From a funding standpoint, the program listed an estimated total funding amount of $10,000,000, with an award ceiling of $2,000,000. The posting date was September 11, 2013, and the record indicates a key closing date of June 30, 2014 (with an original closing date of October 23, 2014), and an archive date of July 30, 2014. There is no cost sharing or matching requirement, which generally means applicants are not expected to provide non-federal matching funds as a condition of the award, although institutions often still contribute space, equipment, or other forms of support to strengthen a center proposal.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (excluding those that are institutions of higher education in the specific category listed), small businesses, for-profit organizations other than small businesses, and a wide range of government bodies such as state governments, county governments, city or township governments, special district governments, public housing authorities/Indian housing authorities, independent school districts, and federally recognized Native American tribal governments. The announcement also explicitly notes additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government. At the same time, non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply; however, foreign components, as defined in the NIH Grants Policy Statement, are allowed, which typically means discrete foreign collaborations or activities can be included when justified, even though the applicant organization itself must be domestic.

Overall, this opportunity is aimed at institutions that can organize a center-scale, collaborative systems biology program with clear scientific integration, the capacity to train researchers in systems approaches, and a plan to share knowledge or engage broader communities through outreach. Applicants are expected to align the center theme with NIGMS priorities in fundamental biomedical science and to propose a structure that can sustain cutting-edge, team-based systems biology research. For full details, including the complete program requirements and application instructions, the official announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-13-351.html, and NIH’s Office of Extramural Research web support is listed as a point of contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).

FAQs: NIGMS National Centers for Systems Biology (P50) - PAR-13-351

What is the NIGMS National Centers for Systems Biology (P50) opportunity (PAR-13-351)?

This is a National Institutes of Health (NIH) discretionary grant program run by the National Institute of General Medical Sciences (NIGMS) to create or support Centers of Excellence in Systems Biology. It uses the NIH P50 Center Grant mechanism and is intended for center-style efforts rather than single-investigator projects.

What is the central purpose of this program?

The program is designed to stimulate ambitious, systems-level research that helps explain biomedical phenomena using integrated, quantitative, and often interdisciplinary approaches. In addition to research, the center concept is expected to include strong environments for research training and outreach.

What kinds of projects are most appropriate for a P50 “center-style” application under this program?

Applications are expected to go beyond a single project or lab and instead bring together multiple investigators and complementary capabilities to tackle complex biological questions. The emphasis is on coordinated, interrelated research components and shared resources typical of a P50 Center Grant.

What research focus is NIGMS looking for in these centers?

The center theme should align with the NIGMS mission, which broadly emphasizes fundamental, generalizable mechanisms in biology that underpin advances in medicine. The opportunity highlights systems-level and quantitative approaches to explaining biomedical phenomena.

Does the opportunity emphasize anything beyond research?

Yes. The announcement explicitly emphasizes not only pioneering research but also developing research training activities and outreach programs as part of the overall center concept. Applicants should plan for both scientific output and workforce or community impact.

What grant mechanism is used?

The funding uses the NIH P50 Center Grant mechanism, which typically supports a coordinated program with multiple interrelated research components and shared resources.

What is the funding activity category and CFDA number?

The funding activity category is Health. The CFDA listing is 93.859 (Biomedical Research and Research Training), reflecting a combined focus on discovery science and training.

How much funding is available and what is the award ceiling?

The estimated total funding amount listed for the program is $10,000,000, and the award ceiling is $2,000,000.

Are applicants required to provide cost sharing or matching funds?

No. The opportunity states there is no cost sharing or matching requirement. While not required, institutions may still choose to contribute space, equipment, or other support to strengthen a center proposal.

When was this opportunity posted?

The posting date listed is September 11, 2013.

What were the key closing and archive dates shown in the record?

The record indicates a key closing date of June 30, 2014 (with an original closing date of October 23, 2014). The archive date listed is July 30, 2014.

Who is eligible to apply?

Eligibility is broad and includes many U.S.-based organizations and governmental entities, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status in the categories listed), small businesses, for-profit organizations (other than small businesses), and various levels of government (state, county, city/township, special districts, public housing authorities/Indian housing authorities, independent school districts, and federally recognized Native American tribal governments).

Are minority-serving institutions specifically mentioned as eligible?

Yes. The announcement explicitly notes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly listed among eligible applicant categories.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are included among the eligible applicant categories.

Are federal government agencies eligible to apply?

Yes. Eligible agencies of the federal government are included in the eligibility description.

Are non-U.S. (foreign) institutions eligible to apply directly?

No. Non-U.S. (foreign) institutions are not eligible to apply for this opportunity.

Can a U.S. organization include non-U.S. components?

No. Non-U.S. components of U.S. organizations are not eligible to apply under this opportunity, as stated in the eligibility description.

Are foreign components allowed at all?

Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. This typically means discrete foreign collaborations or activities may be included when justified, even though the applicant organization itself must be domestic.

Where can applicants find the official funding opportunity announcement and full details?

The official announcement is available at http://grants.nih.gov/grants/guide/pa-files/PAR-13-351.html.

Who is listed as a contact for access or linking issues?

NIH’s Office of Extramural Research web support is listed as a point of contact for access or linking issues at FBOWebmaster@OD.NIH.GOV.

What overall type of institution is this program best suited for?

Based on the description, it is aimed at institutions that can organize a center-scale, collaborative systems biology program with clear scientific integration, capacity to train researchers in systems approaches, and a plan for outreach or broader engagement.

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