Opportunity Information: Apply for RFA NR 12 010
Apply for RFA NR 12 010
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Early Detection and Prevention of Mild Cognitive Impairment (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Mar 21, 2012 and posted on Mar 21, 2012.
- Applicants must submit their applications by May 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) State governments Small businesses Special district governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in theNIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Early Detection and Prevention of Mild Cognitive Impairment (R01) opportunity (Funding Opportunity Number RFA-NR-12-010) was a discretionary NIH grant program led by the National Institute of Nursing Research (NINR) to push forward research on technologies and approaches that could meaningfully change how mild cognitive impairment (MCI) is identified and addressed before it becomes clinically obvious. The central goal was to stimulate work with strong future impact on pre-symptomatic detection and on preventive treatment, management, or intervention strategies for MCI that arises either from aging or from medical treatments. A notable emphasis was also placed on MCI occurring in the context of life-limiting illnesses (LLI), reflecting the need to understand and mitigate cognitive decline in people already facing serious, complex health conditions. The program’s rationale is that detecting cognitive changes earlier, or preventing them altogether, can expand the range of available treatment options, support better planning and care, and ultimately preserve functioning and quality of life for patients and families.
This R01 mechanism is the standard NIH research project grant, typically supporting a defined research plan over multiple years, and it was positioned to fund studies that improve the ability to identify individuals at risk for cognitive decline and to prevent or delay further neurodegeneration. In practical terms, the announcement signals interest in innovative, technology-oriented work that can capture subtle cognitive or neurological changes before traditional clinical symptoms emerge. While the summary text does not list specific mandated methods, the language points toward technology-enabled detection and prevention strategies that could include novel screening tools, monitoring systems, predictive models, biomarkers paired with nursing-relevant outcomes, or other measurement and intervention platforms with real-world applicability. The intended impact is not just academic insight, but actionable capability: better identification of at-risk people and earlier, more effective management that slows progression.
From a funding standpoint, the announcement estimated a total of about $2,500,000 available under the opportunity, with an award ceiling of $350,000 (as presented in the source data). No cost sharing or matching was required. The funding activity category was listed under education and health, and the associated CFDA number was 93.361 (Nursing Research), aligning the program with NINR’s mission and the broader NIH focus on health-related research.
Eligibility was broad across U.S.-based organizations and governments, including state, county, city/township, and special district governments; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; independent school districts; public and private institutions of higher education; nonprofits with and without 501(c)(3) status (with the noted exception categories); and for-profit organizations including small businesses. The eligibility section also explicitly included various mission-specific institution types and community-focused entities such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, the program clearly excluded non-U.S. entities: foreign institutions were not eligible to apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed, indicating the work was intended to be conducted within U.S. organizational structures.
Key administrative dates show the opportunity was posted and created on March 21, 2012, with an original and current closing date of May 21, 2012, and an archive date of June 21, 2012, meaning it was a time-limited call that is no longer open. The administering agency was the National Institutes of Health (NIH), specifically NINR, and the full announcement was provided through the NIH grants guide at the link included in the posting. For access or technical issues with the announcement, the contact route referenced the NIH Office of Extramural Research (OER) webmaster email.
Overall, this funding opportunity can be read as a targeted push by NINR to accelerate practical, technology-forward research that catches cognitive decline early and supports preventive strategies, particularly for older adults and for patients whose cognitive risks are tied to treatments or serious, life-limiting conditions. The expected payoff was improved early identification of risk and better prevention or delay of neurodegenerative changes, translating into preserved cognitive function and better quality of life.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Early Detection and Prevention of Mild Cognitive Impairment (R01).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-NR-12-010.
Which federal agency and institute administered this grant?
The administering agency was the National Institutes of Health (NIH), led by the National Institute of Nursing Research (NINR).
What type of grant mechanism is this?
This opportunity used the NIH R01 mechanism, described as the standard NIH research project grant that typically supports a defined research plan over multiple years.
What was the central purpose of this program?
The central goal was to stimulate research on technologies and approaches that could meaningfully change how mild cognitive impairment (MCI) is identified and addressed before it becomes clinically obvious, with a focus on both early (pre-symptomatic) detection and prevention-oriented strategies.
What outcomes or impacts was the program trying to achieve?
The program rationale emphasized that earlier detection or prevention of cognitive changes can expand available treatment options, support better planning and care, and preserve functioning and quality of life for patients and families. The intended impact was described as actionable capability, not only academic insight.
What kinds of research topics were highlighted as priorities?
Based on the provided description, the announcement signaled interest in innovative, technology-oriented work that improves the ability to identify individuals at risk for cognitive decline and to prevent or delay further neurodegeneration.
Did the opportunity specify required research methods or approaches?
The summary text does not list specific mandated methods. However, it points toward technology-enabled detection and prevention strategies intended to capture subtle cognitive or neurological changes before traditional clinical symptoms emerge.
What are examples of the kinds of projects the announcement seemed to encourage?
Examples suggested by the description include novel screening tools, monitoring systems, predictive models, biomarkers paired with nursing-relevant outcomes, and other measurement and intervention platforms with real-world applicability.
Who was the program especially concerned about in terms of MCI risk?
The opportunity emphasized MCI arising from aging or from medical treatments. It also placed notable emphasis on MCI in the context of life-limiting illnesses (LLI), reflecting the need to understand and mitigate cognitive decline in people facing serious, complex health conditions.
What is the estimated total funding amount available under this opportunity?
The announcement estimated about $2,500,000 in total funding available.
What was the award ceiling?
The award ceiling was listed as $350,000 (as presented in the source data).
Was cost sharing or matching required?
No. The opportunity indicated that no cost sharing or matching was required.
What funding activity category was associated with this opportunity?
The funding activity category was listed under education and health.
What CFDA number was associated with this opportunity?
The associated CFDA number was 93.361 (Nursing Research).
What types of organizations were eligible to apply?
Eligibility was broad across U.S.-based organizations and governments. The description includes state, county, city/township, and special district governments; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; independent school districts; public and private institutions of higher education; nonprofits with and without 501(c)(3) status (with noted exception categories); and for-profit organizations including small businesses.
Were any mission-specific or community-focused institution types explicitly included?
Yes. The eligibility section explicitly included entities such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are foreign institutions eligible to apply?
No. Foreign institutions were not eligible to apply.
Are non-domestic components of U.S. organizations allowed?
No. The opportunity stated that non-domestic components of U.S. organizations were not eligible.
Are foreign components permitted under NIH policy for this opportunity?
No. Foreign components (as defined by NIH policy) were not allowed.
When was this opportunity posted and created?
The opportunity was posted and created on March 21, 2012.
What was the application closing date?
The original and current closing date was May 21, 2012.
Is this funding opportunity still open?
No. The archive date was June 21, 2012, indicating it was a time-limited call that is no longer open.
Where was the full announcement made available?
The full announcement was provided through the NIH grants guide at the link included in the posting.
Who was listed as a contact for access or technical issues?
For access or technical issues with the announcement, the contact route referenced the NIH Office of Extramural Research (OER) webmaster email.
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