Opportunity Information: Apply for PAR 07 102
Apply for PAR 07 102
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Elucidating Nature s Solutions to Heart, Lung, and Blood Diseases and Sleep Disorder Processes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 1, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities Independent school districts Public and State controlled institutions of higher education Private institutions of higher education City or township governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH National Heart, Lung, and Blood Institute (NHLBI) grant opportunity "Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep Disorder Processes (R01)" (Funding Opportunity Number PAR-07-102) supports research aimed at uncovering how certain mammalian species have naturally evolved molecular and cellular strategies that allow them to survive environmental extremes that would quickly cause dangerous cardiovascular or respiratory failure in humans and many other animals. The central idea is that nature has already "solved" some problems related to oxygen deprivation, limited food availability, and temperature stress, and that carefully studying these naturally resilient mammals can reveal biological pathways and mechanisms that could be turned into new therapeutic targets for heart, lung, blood, and sleep-related diseases.
The scientific focus is specifically on adaptive biology rather than conventional disease modeling. Applicants are expected to propose studies that explain the underlying mechanisms that enable survival and normal functioning under extreme conditions such as hypoxia (limited access to oxygen), starvation or food scarcity, and temperature extremes (cold or heat). The FOA emphasizes that it is not intended to fund animal studies that merely replicate or track the progression of human cardiovascular or respiratory diseases in standard model organisms. Instead, the work should be grounded in discovering evolved protective mechanisms in mammals that thrive under conditions that would otherwise trigger life-threatening responses, with the longer-term goal of translating those insights into prevention or treatment strategies for human disease, including sleep disorder processes that intersect with cardiopulmonary physiology.
Funding is provided through the NIH Research Project Grant (R01) mechanism. Projects can vary in scope, but the FOA caps support at up to $250,000 per year in direct costs for a project period of up to four years. There is no dedicated set-aside pool of funds and no fixed number of awards; how many projects are funded depends on application quality, scientific merit, program priorities, and the requested budgets and durations. The opportunity lists multiple receipt dates rather than a single deadline, and applicants are directed to the full announcement for the specific submission cycles and details.
Eligibility is broad and includes many types of domestic U.S. organizations such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), state and local governments (city/township, county, special district), independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The FOA also allows applications from foreign institutions and eligible federal agencies, and notes that faith-based and community-based organizations may apply. The opportunity falls under NIH health research funding and is associated with CFDA areas covering sleep disorders research and cardiovascular, lung, and blood diseases and resources (including 93.233, 93.837, 93.838, and 93.839).
In practical terms, a competitive project under this FOA would typically identify a mammalian species with a well-documented extreme-environment phenotype (for example, remarkable tolerance to low oxygen, prolonged fasting, or extreme cold), then use modern molecular, cellular, physiological, and comparative approaches to define the protective adaptations responsible. The deliverable NHLBI is looking for is not simply descriptive observations, but mechanistic insight that points to actionable targets, pathways, or protective programs that could plausibly be leveraged to prevent or treat human heart, lung, blood, or sleep-related disorders. The full FOA is available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-07-102.html.
Frequently Asked Questions (FAQs)
What is the name of this NIH grant opportunity?
The opportunity is titled "Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep Disorder Processes (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-07-102.
Which NIH Institute is sponsoring this grant?
This funding opportunity is offered by the NIH National Heart, Lung, and Blood Institute (NHLBI).
What is the main purpose of this FOA?
The goal is to support research that explains how certain mammalian species have naturally evolved molecular and cellular strategies that let them survive environmental extremes that would quickly cause dangerous cardiovascular or respiratory failure in humans and many other animals.
What is the central scientific idea behind the program?
The FOA is based on the concept that nature has already "solved" some biological problems related to oxygen deprivation, limited food availability, and temperature stress. By studying naturally resilient mammals, researchers can uncover pathways and mechanisms that may become new therapeutic targets for heart, lung, blood, and sleep-related diseases.
What types of environmental extremes are specifically highlighted?
The FOA emphasizes extreme conditions such as hypoxia (limited access to oxygen), starvation or food scarcity, and temperature extremes (cold or heat).
Is this opportunity focused on adaptive biology or traditional disease modeling?
The scientific focus is adaptive biology. Applicants are expected to propose studies that explain evolved protective mechanisms that enable survival and normal function under extreme conditions.
Does the FOA support conventional animal disease models of human cardiovascular or respiratory disease?
No. The FOA states it is not intended to fund animal studies that merely replicate or track the progression of human cardiovascular or respiratory diseases in standard model organisms.
What kind of outcomes is NHLBI looking for from funded projects?
NHLBI is looking for mechanistic insight rather than purely descriptive observations. The desired deliverables include identifying actionable targets, pathways, or protective programs that could plausibly be leveraged to prevent or treat human heart, lung, blood, or sleep-related disorders.
How does sleep disorder research fit into this FOA?
The FOA includes sleep disorder processes that intersect with cardiopulmonary physiology, alongside heart, lung, and blood disease areas.
What grant mechanism is used for this opportunity?
Funding is provided through the NIH Research Project Grant (R01) mechanism.
How much funding can an applicant request?
The FOA caps support at up to $250,000 per year in direct costs.
How long can the project period be?
The project period can be up to four years.
Is there a set-aside pool of funds or a guaranteed number of awards?
No. The FOA indicates there is no dedicated set-aside pool of funds and no fixed number of awards.
What determines how many awards are made?
According to the FOA description, the number of projects funded depends on application quality, scientific merit, program priorities, and the requested budgets and durations.
Is there a single application deadline?
No. The opportunity lists multiple receipt dates rather than a single deadline. Applicants are directed to the full announcement for the specific submission cycles and details.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. organizations, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and various government entities.
Which U.S. government entities are included as eligible applicants?
Eligible entities include state and local governments (including city/township, county, and special district governments), independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are listed as eligible applicants.
Can faith-based or community-based organizations apply?
Yes. The FOA notes that faith-based and community-based organizations may apply.
Are foreign institutions eligible to apply?
Yes. The FOA allows applications from foreign institutions.
Are federal agencies eligible to apply?
Yes. The FOA allows applications from eligible federal agencies.
What kinds of research approaches are expected to be used?
The FOA anticipates the use of modern molecular, cellular, physiological, and comparative approaches to define the protective adaptations responsible for extreme-environment resilience.
What would a competitive project look like under this FOA?
A competitive project would typically identify a mammalian species with a well-documented extreme-environment phenotype (such as tolerance to low oxygen, prolonged fasting, or extreme cold) and then conduct mechanistic studies to explain the evolved protective adaptations that enable survival and normal functioning under those conditions.
Is descriptive natural history or observation alone sufficient?
No. The FOA emphasizes that the deliverable should not be simply descriptive observations, but mechanistic insight that can point toward actionable biology relevant to human prevention or treatment strategies.
Which disease and research areas are associated with this opportunity (CFDA areas)?
The opportunity is associated with CFDA areas covering sleep disorders research and cardiovascular, lung, and blood diseases and resources, including 93.233, 93.837, 93.838, and 93.839.
Where can applicants find the full FOA announcement?
The full FOA is available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-07-102.html.
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