Opportunity Information: Apply for PA 10 249
Apply for PA 10 249
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 4, 2010 and posted on Aug 4, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health (NIH) released this funding opportunity announcement (FOA) to support research on how the endocannabinoid (eCB) signaling system influences alcohol-related behaviors and alcohol use disorders. The central goal is to encourage R01 Research Project Grant applications that examine the roles and mechanisms of eCB signaling in alcohol preference, alcohol consumption, intoxication, and the development or persistence of alcohol use disorders, while also evaluating components of the eCB system as possible targets for medications to treat alcohol problems. The FOA is grounded in growing evidence that alcohol interacts with eCB signaling in the brain, and that understanding this relationship could clarify why alcohol is reinforcing for some individuals and how alcohol produces both short-term intoxication effects and long-term brain changes that contribute to addiction.
From a scientific scope standpoint, the announcement emphasizes mechanistic work that can connect eCB signaling to specific alcohol outcomes. It highlights interest in studies that explain how eCB signaling affects alcohol preference and drinking levels, how acute versus chronic alcohol exposure interacts with eCB signaling at synapses, and how those interactions alter synaptic plasticity in both the short and long term. It also calls attention to developmental questions, including how eCB signaling contributes to the development and maturation of the central nervous system, and how disruptions involving the eCB system may be relevant to fetal alcohol spectrum disorders. Overall, the FOA is aimed at research that can move beyond simple associations and help explain the biological pathways linking eCB signaling with alcohol’s effects on the brain and behavior, including work that could inform pharmacotherapy development.
The mechanism of support is the NIH R01, which is designed for discrete, hypothesis-driven research projects with a well-developed plan. This FOA runs in parallel with a companion announcement of identical scientific scope that uses the R21 mechanism (PA-10-250), which typically supports earlier-stage or exploratory projects, whereas this PA-10-249 is focused on full R01-scale projects. Because project aims can vary widely, the FOA does not specify a single award size or project duration; instead, the number of awards and total funding depend on the volume and quality of applications, along with the proposed budgets and timelines.
In terms of eligibility, the opportunity is broadly open to a wide range of applicant organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and various levels of government (state and county). It also explicitly includes tribal governments and tribal organizations, historically underrepresented and mission-specific institutions (such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities), faith-based and community-based organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations), as well as eligible agencies of the federal government and regional organizations. The FOA states there is no cost-sharing or matching requirement.
Key administrative details include the funding opportunity number PA-10-249, the title "Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R01)," and classification under CFDA 93.273 (Alcohol Research Programs). It was posted on August 4, 2010, and the original and current closing date listed is September 7, 2013, with an archive date of October 8, 2013. The sponsoring agency is NIH (with NIAAA as the lead institute for this FOA). For applicants who have trouble accessing the full announcement or experience technical issues, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV. The full announcement link provided is http://grants.nih.gov/grants/guide/pa-files/PA-10-249.html.
Frequently Asked Questions (FAQs)
What is the main purpose of this funding opportunity?
This FOA supports research on how the endocannabinoid (eCB) signaling system influences alcohol-related behaviors and alcohol use disorders. The goal is to encourage R01 applications that explain roles and mechanisms of eCB signaling in alcohol preference, alcohol consumption, intoxication, and the development or persistence of alcohol use disorders, including evaluating parts of the eCB system as possible medication targets for alcohol problems.
Which agency and institute are sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) as the lead institute for this FOA.
What is the funding opportunity number and title?
The funding opportunity number is PA-10-249. The title is "Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R01)."
What grant mechanism does this announcement use?
This announcement uses the NIH R01 Research Project Grant mechanism, which is intended for discrete, hypothesis-driven research projects with a well-developed research plan.
Is there a related or companion funding opportunity?
Yes. The FOA runs in parallel with a companion announcement of identical scientific scope that uses the R21 mechanism (PA-10-250). The R21 is typically used for earlier-stage or exploratory projects, while PA-10-249 is focused on full R01-scale projects.
What research topics and outcomes are emphasized in the scientific scope?
The FOA emphasizes mechanistic studies that connect eCB signaling to specific alcohol outcomes. Examples of emphasized areas include how eCB signaling affects alcohol preference and drinking levels, how acute versus chronic alcohol exposure interacts with eCB signaling at synapses, and how these interactions alter synaptic plasticity in both the short and long term.
Does the FOA encourage studies beyond simple associations?
Yes. The announcement specifically aims to move beyond simple associations by supporting work that can explain biological pathways linking eCB signaling with alcohol’s effects on the brain and behavior.
Is pharmacotherapy development or medication targeting part of the goal?
Yes. The FOA includes evaluating components of the eCB system as possible targets for medications to treat alcohol problems, and it highlights research that could inform pharmacotherapy development.
Are developmental and fetal alcohol spectrum disorder (FASD) questions within scope?
Yes. The FOA calls attention to developmental questions, including how eCB signaling contributes to central nervous system development and maturation, and how disruptions involving the eCB system may be relevant to fetal alcohol spectrum disorders.
What does the FOA say about alcohol and eCB signaling interactions?
The FOA is grounded in growing evidence that alcohol interacts with eCB signaling in the brain, and that understanding this relationship may clarify why alcohol is reinforcing for some individuals and how alcohol produces short-term intoxication effects and long-term brain changes that contribute to addiction.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; state and county governments; tribal governments and tribal organizations; U.S. territories or possessions; non-U.S. entities (foreign organizations); eligible agencies of the federal government; and regional organizations.
Are mission-specific or underrepresented institutions explicitly included?
Yes. The FOA explicitly includes institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible applicants.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
Is cost sharing or matching required?
No. The FOA states that there is no cost-sharing or matching requirement.
How much funding is available per award, and how long can projects last?
The FOA does not specify a single award size or project duration. Because project aims can vary widely, budgets and timelines are expected to be proposed by applicants, and the number of awards and total funding depend on the volume and quality of applications as well as proposed budgets and timelines.
What is the CFDA number and program classification?
The FOA is classified under CFDA 93.273 (Alcohol Research Programs).
When was the opportunity posted, and what are the key dates?
The FOA was posted on August 4, 2010. The original and current closing date listed is September 7, 2013, and the archive date is October 8, 2013.
Where can applicants find the full announcement?
The full announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-10-249.html
Who should be contacted for trouble accessing the announcement or technical issues?
For access problems or technical issues related to the full announcement, the FOA lists the NIH Office of Extramural Research (OER) webmaster as the point of contact: FBOWebmaster@OD.NIH.GOV.
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