Opportunity Information: Apply for PA 10 250
Apply for PA 10 250
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 4, 2010 and posted on Aug 4, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments City or township governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R21) funding opportunity (PA-10-250) is a National Institutes of Health (NIH) grant announcement issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Its main goal is to support exploratory, early-stage research that clarifies how the endocannabinoid (eCB) system influences alcohol-related behaviors and disease. In practical terms, NIAAA is looking for research projects that explain the roles and mechanisms of eCB signaling in alcohol preference, alcohol intake, intoxication, and the development and maintenance of alcohol use disorders, while also assessing whether components of the eCB system could serve as promising targets for medications to treat alcohol problems.
The scientific rationale behind the opportunity is that the eCB system is now understood to be a major regulator of brain function in both developing and adult nervous systems, and there is growing behavioral and pharmacological evidence that alcohol interacts with eCB signaling. Because alcohol and eCB pathways appear to intersect at multiple levels (including synapses and neural circuits involved in reward, stress, learning, and decision-making), NIAAA is encouraging investigators to pursue projects that can open up new mechanistic insights. The announcement emphasizes that supported studies should advance understanding of how eCB signaling contributes to alcohol preference and consumption, how acute versus chronic alcohol exposure affects eCB activity at synapses, and how those interactions influence short-term and long-term synaptic plasticity. It also highlights developmental questions, including the role of eCB signaling in central nervous system development and maturation, and how alterations in eCB signaling may be relevant to fetal alcohol spectrum disorders.
This opportunity uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is typically intended for innovative, higher-risk projects that can generate foundational data, validate new concepts, or establish feasibility for larger studies. The FOA is described as running in parallel with a companion announcement of the same scientific scope that uses the R01 mechanism (PA-10-249), meaning applicants should choose the activity code that best fits their stage of evidence, scale, and project maturity. The R21 framework signals that NIAAA expects creative approaches and emerging ideas, rather than fully built-out, long-term programs of research.
On funding levels, the posted award ceiling is listed as $200,000, and the FOA notes that both the number of awards and the final award sizes will vary depending on the mix of applications received, their quality, their proposed duration, and their budgets. There is no cost-sharing or matching requirement, which means applicants are not required to bring non-federal dollars to the project as a condition of funding. The opportunity is categorized under health-related discretionary grants, associated with CFDA 93.273 (Alcohol Research Programs).
Eligibility is broad and includes many common NIH applicant organizations across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses, with the note that eligibility is not limited to small businesses); state, county, city/township, and special district governments; independent school districts; and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes a wide range of mission- or community-focused institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations (including federally recognized tribal governments and other tribal entities as specified), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. It also indicates that non-U.S. entities (foreign organizations) may apply, which can be important for specialized neuroscience, pharmacology, or developmental biology expertise located outside the United States.
Key dates in the source data indicate the FOA was posted on August 4, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013. That means this specific announcement is historically informative but no longer open for new submissions. The full announcement was hosted on the NIH Grants Guide, and the contact information provided points applicants to the NIH Office of Extramural Research (OER) webmaster for technical difficulties accessing the posting.
Overall, the grant opportunity is centered on a focused, mechanistic neuroscience and pharmacology theme: understanding how endocannabinoid signaling shapes alcohol-related behaviors and pathology, from synaptic effects and plasticity to developmental impacts, with a clear translational angle aimed at identifying potential eCB-related targets for alcohol pharmacotherapy.
FAQs: Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R21) (PA-10-250)
What is PA-10-250?
PA-10-250 is a National Institutes of Health (NIH) funding opportunity announcement issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) titled "The Endocannabinoid Signaling in Alcohol Consumption, Intoxication and Alcohol Use Disorders (R21)." It supports exploratory research on how endocannabinoid (eCB) signaling influences alcohol-related behaviors and alcohol use disorders.
Which agency and institute sponsor this opportunity?
This opportunity is an NIH grant announcement sponsored by NIAAA (National Institute on Alcohol Abuse and Alcoholism).
What is the primary goal of this funding opportunity?
The main goal is to support early-stage, exploratory research that clarifies how the endocannabinoid system affects alcohol preference, alcohol intake, intoxication, and the development and maintenance of alcohol use disorders, including whether components of the eCB system could be targets for medications to treat alcohol-related problems.
What types of research are emphasized?
The announcement emphasizes mechanistic studies that improve understanding of how eCB signaling contributes to alcohol preference and consumption, how acute versus chronic alcohol exposure affects eCB activity at synapses, and how these interactions influence short-term and long-term synaptic plasticity.
Does the FOA include a translational or medication-development angle?
Yes. A specific emphasis is assessing whether components of the eCB system could serve as promising targets for medications to treat alcohol problems.
Why is the endocannabinoid system considered important for alcohol research in this FOA?
The scientific rationale described is that the eCB system is a major regulator of brain function in developing and adult nervous systems, and behavioral and pharmacological evidence suggests alcohol interacts with eCB signaling. The FOA notes that alcohol and eCB pathways may intersect at multiple levels, including synapses and neural circuits involved in reward, stress, learning, and decision-making.
Are developmental topics within scope?
Yes. The announcement highlights developmental questions, including the role of eCB signaling in central nervous system development and maturation, and how alterations in eCB signaling may be relevant to fetal alcohol spectrum disorders.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Exploratory/Developmental Research Grant mechanism (R21).
What does it mean that this is an R21 opportunity?
In the FOA description, the R21 mechanism is positioned as supporting innovative, higher-risk projects intended to generate foundational data, validate new concepts, or establish feasibility for larger studies, rather than fully built-out long-term programs of research.
Is there a related funding opportunity using a different mechanism?
Yes. The FOA is described as running in parallel with a companion announcement of the same scientific scope that uses the R01 mechanism (PA-10-249). Applicants are expected to choose the activity code that best fits their stage of evidence, scale, and project maturity.
What is the maximum award amount listed?
The posted award ceiling is listed as $200,000.
How many awards will be made?
The FOA indicates the number of awards will vary depending on the mix of applications received and their quality, as well as proposed duration and budgets.
Will all awards be funded at the same amount?
No. The FOA notes that final award sizes will vary depending on application quality, proposed duration, and budget, among other factors.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement, meaning applicants are not required to provide non-federal dollars as a condition of funding.
How is this opportunity categorized?
It is categorized under health-related discretionary grants and is associated with CFDA 93.273 (Alcohol Research Programs).
Who is eligible to apply?
Eligibility is broad and includes many common NIH applicant organization types across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses, with eligibility not limited to small businesses); and multiple levels of government entities.
Are state and local government entities eligible?
Yes. The eligibility list includes state governments, county governments, city/township governments, and special district governments.
Are school districts eligible?
Yes. Independent school districts are explicitly listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included in the eligibility language.
Are minority-serving institutions and community-focused entities included?
Yes. The eligibility language explicitly includes institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are tribal governments or tribal organizations eligible?
Yes. The eligibility language includes federally recognized tribal governments and other tribal entities as specified, along with tribal organizations.
Can foreign (non-U.S.) organizations apply?
Yes. The opportunity indicates that non-U.S. entities (foreign organizations) may apply.
Is this funding opportunity still open?
No. The key dates provided indicate the FOA was posted on August 4, 2010, had a closing date of September 7, 2013, and an archive date of October 8, 2013. Based on those dates, this specific announcement is no longer open for new submissions.
Where was the full announcement hosted?
The full announcement was hosted on the NIH Grants Guide.
Who should be contacted for technical problems accessing the posting?
The contact information provided points to the NIH Office of Extramural Research (OER) webmaster for technical difficulties accessing the posting.
What scientific areas does this FOA connect to?
Based on the description provided, the FOA centers on mechanistic neuroscience and pharmacology related to alcohol behaviors and pathology, including synaptic effects, neural circuit function (reward, stress, learning, decision-making), synaptic plasticity, and developmental impacts, with a translational emphasis on potential pharmacotherapy targets.
What is the practical research focus stated in the opportunity description?
In practical terms, NIAAA is looking for research projects that explain roles and mechanisms of eCB signaling in alcohol preference, alcohol intake, intoxication, and the development and maintenance of alcohol use disorders, while assessing whether eCB system components could be promising medication targets.
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