Opportunity Information: Apply for RFA HD 14 025
Apply for RFA HD 14 025
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Enhancing the Capacity for Biomedical Research on Tuberculosis for HIV infected Mothers and Children in India (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 28, 2013 and posted on Oct 28, 2013.
- Applicants must submit their applications by Dec 27, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Enhancing the Capacity for Biomedical Research on Tuberculosis for HIV infected Mothers and Children in India (R01)" (Funding Opportunity Number RFA-HD-14-025) is a National Institutes of Health (NIH) research project grant that focused on strengthening and expanding biomedical research capacity in India around tuberculosis (TB), particularly where TB intersects with HIV in vulnerable populations. The core idea behind the announcement is to build on newly created Cohort Research Units in India, which were established through U.S.-India collaborations among governments, investigators, and institutions. These Cohort Research Units were designed to support long-term, longitudinal cohort studies of TB patients and their close contacts, including people with TB/HIV co-infection, alongside the development of associated laboratory infrastructure capable of supporting fundamental biomedical research.
Within that broader platform, the specific purpose of this R01 announcement was to invite research proposals that deliberately include children and pregnant women who are either HIV-infected or HIV-uninfected, and who have TB exposure, TB infection (including latent infection), or active TB disease. In practice, this means the FOA encouraged applicants to embed maternal and pediatric research questions into the existing or emerging cohort structures in India, so that the cohorts do not only represent adult TB cases but also capture the unique clinical, immunologic, and public health dynamics of TB in pregnancy and childhood, especially in settings where HIV may increase susceptibility, complicate diagnosis, and worsen outcomes.
The funding mechanism was the NIH R01, meaning applicants were expected to propose a clearly defined research project with specific aims, a rigorous study design, and a feasible plan for implementation within the Indian cohort infrastructure. The announcement aligned with capacity-building as well as hypothesis-driven science: it was not simply about collecting cases, but about using the cohort framework and laboratory resources to generate high-quality biomedical evidence related to TB in mothers and children affected by HIV risk or infection. The announcement was tied to the NIH activity area of health, under the CFDA number 93.865 (Child Health and Human Development Extramural Research), signaling an emphasis on maternal and child health dimensions of infectious disease research.
From a funding and administrative standpoint, the opportunity was discretionary and used the standard grant instrument. It did not require cost sharing or matching. NIH estimated total funding of about $1,000,000 for the initiative, with an award ceiling of $350,000 (generally interpreted as the maximum direct costs or total costs per award depending on the FOA specifics, but the ceiling indicates the upper bound NIH expected for individual awards under this announcement). The FOA was posted on October 28, 2013, and the original and current closing date was December 27, 2013, with an archive date of January 27, 2014, meaning it is no longer active but remains available as a historical opportunity and reference point.
Eligibility was broad and included a wide range of domestic U.S. organizational types such as public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities. Importantly, the FOA also explicitly allowed non-U.S. entities and foreign institutions to apply, as well as non-U.S. components of U.S. organizations, and it permitted foreign components under NIH policy. It further listed categories of institutions often emphasized in federal eligibility language, such as Minority Serving Institutions (including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities), faith-based or community-based organizations, and tribal governments, reflecting NIH's general approach to broad institutional participation while still requiring strong scientific and operational capability.
In short, this NIH R01 opportunity aimed to leverage newly established TB cohort and laboratory platforms in India to support rigorous, longitudinal biomedical research that specifically incorporates HIV-infected and uninfected pregnant women and children affected by TB exposure, infection, or disease. It sought to advance scientific understanding and strengthen research capacity where TB and HIV overlap in maternal and pediatric populations, using cohort-based approaches and strengthened laboratory resources as the foundation for durable, high-impact research programs.
Frequently Asked Questions (FAQs)
What is the official title of this grant opportunity?
The opportunity is titled "Enhancing the Capacity for Biomedical Research on Tuberculosis for HIV infected Mothers and Children in India (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HD-14-025.
Which agency offered this funding opportunity?
This was offered by the National Institutes of Health (NIH).
What type of grant mechanism was used?
The funding mechanism was the NIH R01 (Research Project Grant), which typically supports a defined research project with specific aims, a rigorous design, and a feasible implementation plan.
What was the main purpose of this FOA?
The FOA focused on strengthening and expanding biomedical research capacity in India related to tuberculosis (TB), with particular emphasis on TB where it intersects with HIV in vulnerable populations, especially mothers and children.
What research platform or infrastructure did this FOA build upon?
It built on newly created Cohort Research Units in India that were established through U.S.-India collaborations among governments, investigators, and institutions. These units were designed to support long-term, longitudinal cohort studies of TB patients and their close contacts, including people with TB/HIV co-infection, and to develop associated laboratory infrastructure for fundamental biomedical research.
Why were Cohort Research Units important to this opportunity?
They provided a foundation for longitudinal cohort studies and supported laboratory capacity needed for high-quality biomedical research, enabling durable research programs rather than one-off studies.
What populations were specifically encouraged for inclusion in proposed research?
The FOA encouraged proposals that deliberately include children and pregnant women who are HIV-infected or HIV-uninfected and who have TB exposure, TB infection (including latent infection), or active TB disease.
Did the FOA focus only on HIV-infected participants?
No. The FOA explicitly encouraged inclusion of both HIV-infected and HIV-uninfected pregnant women and children, as long as TB exposure, infection (including latent infection), or active TB disease was part of the research focus.
What TB-related conditions were within scope?
The scope included TB exposure, TB infection (including latent TB infection), and active TB disease.
What was the geographic focus of the research capacity-building?
The capacity-building and cohort-based platform referenced in the FOA was centered in India.
How were maternal and pediatric questions expected to fit into the cohort work?
The FOA encouraged applicants to embed maternal and pediatric research questions into existing or emerging cohort structures so the cohorts would capture the unique clinical, immunologic, and public health dynamics of TB in pregnancy and childhood, including settings where HIV may affect susceptibility, diagnosis, and outcomes.
Was this opportunity aimed at capacity-building, hypothesis-driven science, or both?
Both. It aligned capacity-building with hypothesis-driven research by emphasizing the use of cohort frameworks and laboratory resources to generate high-quality biomedical evidence, not simply to collect cases.
What NIH activity area or program area was associated with this FOA?
The announcement was tied to the NIH activity area of health and referenced CFDA number 93.865 (Child Health and Human Development Extramural Research), signaling an emphasis on maternal and child health dimensions of infectious disease research.
What is the CFDA number listed for this opportunity?
The CFDA number is 93.865 (Child Health and Human Development Extramural Research).
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching.
What was the estimated total funding amount for the initiative?
NIH estimated total funding of about $1,000,000 for the initiative.
What was the award ceiling for individual awards?
The FOA listed an award ceiling of $350,000, described as an upper bound NIH expected for individual awards under this announcement (often interpreted as maximum direct costs or total costs depending on FOA specifics).
What kind of award instrument was used?
The opportunity was discretionary and used the standard grant instrument.
When was the FOA posted?
The FOA was posted on October 28, 2013.
What was the closing date for applications?
The original and current closing date was December 27, 2013.
Is this FOA still active?
No. It is no longer active. It was archived on January 27, 2014, and remains available as a historical opportunity and reference point.
What types of U.S. organizations were eligible to apply?
Eligibility included a broad range of domestic U.S. organizations, including public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities.
Were non-U.S. entities or foreign institutions eligible?
Yes. The FOA explicitly allowed non-U.S. entities and foreign institutions to apply.
Could non-U.S. components of U.S. organizations be involved?
Yes. The FOA allowed non-U.S. components of U.S. organizations and permitted foreign components under NIH policy.
Did the FOA highlight participation by Minority Serving Institutions or community-based organizations?
Yes. It listed categories often emphasized in federal eligibility language, including Minority Serving Institutions (such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities), as well as faith-based or community-based organizations and tribal governments.
What overall goal did NIH appear to be pursuing through this FOA?
The FOA aimed to leverage TB cohort and laboratory platforms in India to support rigorous, longitudinal biomedical research that incorporates HIV-infected and uninfected pregnant women and children affected by TB exposure, infection, or disease, strengthening research capacity and advancing scientific understanding where TB and HIV overlap in maternal and pediatric populations.
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