Opportunity Information: Apply for PA 11 160
Apply for PA 11 160
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 17, 2011 and posted on Mar 17, 2011.
- Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Special district governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Independent school districts State governments For profit organizations other than small businesses County governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The NIH grant opportunity PA-11-160, titled "Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)," is a discretionary research grant (R01 mechanism) intended to drive studies that clarify how specific dietary components influence the cancer-killing (tumoricidal) function of natural killer (NK) cells, and why that influence matters in real physiological settings for cancer prevention. In practical terms, the FOA is centered on nutrition and immunology at the intersection of cancer prevention research: it encourages applicants to move beyond general claims that "diet affects immunity" and instead produce rigorous evidence that particular nutrients, bioactive food compounds, or dietary patterns can measurably modulate NK cell activity in ways that are relevant to preventing cancer initiation or early progression.
The scientific focus is on establishing physiological significance, meaning the work should aim to demonstrate not only that a dietary component can change NK cell behavior in a lab setting, but that the observed changes are meaningful within living systems and prevention contexts. Projects aligned with this FOA would typically investigate how dietary factors affect NK cell-mediated surveillance against emerging malignant cells, how NK cell cytotoxic mechanisms are altered by diet-derived compounds, and what mechanisms connect nutritional exposure to immune effector function. The prevention angle implies interest in early events and modifiable exposures rather than therapeutic interventions alone, with an emphasis on understanding how nutrition could strengthen innate immune defenses before clinically evident cancer develops.
Administratively, this opportunity is issued by the National Institutes of Health and falls within health and education-related research activity categories. It is associated with CFDA program areas that include complementary and integrative health research and multiple cancer research categories (cause and prevention research, and cancer biology research), reflecting the FOA's blend of basic biology, prevention science, and potentially translational nutrition research. The FOA does not require cost sharing or matching, which generally lowers the barrier to participation for a broad range of applicants.
Eligibility is intentionally broad. Applicants may include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities other than universities), small businesses, and for-profit organizations (including those other than small businesses). A wide range of government entities are eligible as well, including state, county, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA explicitly includes tribal governments and tribal organizations, along with institutions serving specific populations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Faith-based and community-based organizations are also identified as eligible. Importantly, the FOA allows participation by non-U.S. entities (foreign organizations) and regional organizations, and it permits foreign components of U.S. organizations, signaling openness to internationally relevant nutrition-immunology research where appropriate.
Key dates show that the FOA was posted and created on March 17, 2011, with an original and final closing date of May 7, 2014, and an archive date of June 7, 2014. That means it is no longer open for new submissions under this specific announcement, but it remains useful as a reference point for the type of research NIH sought to stimulate in this area and for identifying themes that may reappear in later NIH funding opportunities related to diet, innate immunity, and cancer prevention.
For further details, the full announcement was hosted on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-11-160.html. The listed support contact for access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is PA-11-160?
PA-11-160 is an NIH grant funding opportunity announcement (FOA) titled "Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01)." It was designed to support research that explains how specific dietary components influence the cancer-killing activity of natural killer (NK) cells, with an emphasis on cancer prevention relevance.
Which agency offered this opportunity?
The opportunity was issued by the National Institutes of Health (NIH).
What type of grant mechanism is used?
This FOA used the R01 mechanism, which is a discretionary research grant mechanism intended to support defined, hypothesis-driven research projects.
What is the main scientific goal of this FOA?
The FOA sought studies that move beyond broad statements like "diet affects immunity" and instead generate rigorous evidence that particular nutrients, bioactive food compounds, or dietary patterns can measurably modulate NK cell activity in ways that matter for preventing cancer initiation or early progression.
What does "enhancing tumoricidal activity" mean in this context?
In this context, it refers to strengthening or improving the ability of NK cells to recognize and kill emerging malignant or abnormal cells as part of innate immune surveillance, specifically through the influence of dietary exposures.
What research areas does PA-11-160 sit between?
The FOA sits at the intersection of nutrition, immunology, and cancer prevention research. It emphasizes understanding how nutrition-related exposures can affect innate immune effector functions relevant to preventing cancer.
Does the FOA emphasize cancer treatment or cancer prevention?
The FOA emphasizes cancer prevention, with interest in early events and modifiable exposures rather than therapeutic interventions alone. The intent is to understand how nutrition could strengthen innate immune defenses before clinically evident cancer develops.
What does the FOA mean by "physiological significance"?
"Physiological significance" means the research should aim to show not only that a dietary component can change NK cell behavior in a laboratory setting, but also that those changes are meaningful in living systems and in prevention contexts (for example, in ways that affect immune surveillance against emerging malignant cells).
What kinds of dietary factors were relevant under this FOA?
Based on the description, relevant dietary factors included specific nutrients, bioactive food compounds, and dietary patterns, as long as the work could demonstrate measurable effects on NK cell activity tied to cancer prevention significance.
What kinds of NK cell endpoints or themes were aligned with the FOA?
Aligned themes included how dietary factors affect NK cell-mediated surveillance against emerging malignant cells, how NK cell cytotoxic mechanisms are altered by diet-derived compounds, and what mechanisms connect nutritional exposure to immune effector function.
What activity categories were associated with this FOA?
The FOA fell within health and education-related research activity categories.
Which CFDA program areas were associated with this opportunity?
The FOA was associated with CFDA program areas that included complementary and integrative health research and multiple cancer research categories, including cancer cause and prevention research and cancer biology research.
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities other than universities); small businesses; and for-profit organizations (including those other than small businesses).
Are government entities eligible?
Yes. Eligible government entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly included tribal governments and tribal organizations as eligible applicants.
Does the FOA encourage applications from institutions serving specific populations?
Yes. The FOA identified eligibility for institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and similar organizations serving specific populations.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were identified as eligible under the FOA.
Could foreign organizations apply?
Yes. The FOA allowed participation by non-U.S. entities (foreign organizations) and regional organizations, and it permitted foreign components of U.S. organizations.
When was PA-11-160 posted and created?
The FOA was posted and created on March 17, 2011.
What were the closing dates for this FOA?
The FOA listed an original closing date and a final closing date of May 7, 2014.
Is PA-11-160 still open for applications?
No. The FOA is no longer open for new submissions under this specific announcement. It was archived on June 7, 2014.
If it is closed, why does PA-11-160 still matter?
Even though it is closed, it can still be useful as a reference for the type of research NIH aimed to stimulate in this area and for identifying themes that may reappear in later NIH opportunities related to diet, innate immunity, and cancer prevention.
Where can the full FOA text be found?
The full announcement was hosted on the NIH grants site at: http://grants.nih.gov/grants/guide/pa-files/PA-11-160.html
Who is listed as the support contact for access or linking issues?
The NIH Office of Extramural Research (OER) Webmaster is listed for access or linking issues: FBOWebmaster@OD.NIH.GOV
Browse more opportunities from the same category: Education Health
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