Opportunity Information: Apply for PAR 11 131
Apply for PAR 11 131
- The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Enhancing Zebrafish Research with Research Tools and Techniques (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.233 National Center on Sleep Disorders Research 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Mar 30, 2011 and posted on Mar 30, 2011.
- Applicants must submit their applications by Sep 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities Independent school districts City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
Enhancing Zebrafish Research with Research Tools and Techniques (R01) is an NIH discretionary grant funding opportunity (Funding Opportunity Number PAR-11-131) aimed at strengthening the zebrafish as a vertebrate model system for biomedical and behavioral research. The program specifically calls for investigator-initiated R01 applications that create, improve, or expand research tools and techniques that the broader zebrafish community considers high priority. The underlying idea is that well designed, broadly useful tools can accelerate discovery across many fields by making it easier to detect, measure, manipulate, and interpret genes, biological pathways, and observable traits (phenotypes) in zebrafish.
The scientific scope is intentionally wide, but it is clearly centered on enabling capabilities rather than funding any single disease project in isolation. NIH is looking for tool and technique development that advances studies of development and aging, organ formation, nervous system function, neural circuits, behavior, sensory processing, physiology, and disease processes. In practical terms, this can include innovations that improve how researchers identify genes and pathways, track cell lineages, visualize structures and activity, quantify behavior, measure physiological outputs, or model and characterize disease related phenotypes in zebrafish. The emphasis on detection and characterization highlights that applications should not just propose incremental improvements, but should meaningfully increase what can be observed, measured, or tested in zebrafish, ideally in ways that can be adopted by other labs.
The opportunity stems from an NIH-wide initiative coordinated through the Trans-NIH Zebrafish Coordinating Committee (TZCC), co-chaired by NICHD and NIDDK, which signals that multiple NIH Institutes and Centers see zebrafish tool development as a shared infrastructure need. Consistent with that trans-NIH framing, the funding is associated with a broad set of CFDA program areas spanning environmental health, oral health, communication disorders, sleep, alcohol, drug abuse, cancer biology, cardiovascular and lung diseases, blood resources, diabetes/digestive/kidney research, general biomedical research and training, child health and human development, aging, and vision research. This breadth underscores that proposed tools should ideally have cross-cutting value, enabling progress in many biological and disease areas rather than serving a narrow niche.
From an administrative standpoint, the mechanism is an R01 research project grant, with no cost sharing or matching requirement. The announcement was posted and created on March 30, 2011, with an original and final closing date of September 19, 2013, and an archive date of October 20, 2013. While that means this specific FOA is historical and no longer open, it remains a useful reference point for the type of zebrafish-focused tool development NIH has prioritized and how NIH frames community enabling resources.
Eligibility is broad and includes many organization types. Eligible applicants listed include for-profit organizations (including small businesses and other for-profits), nonprofit organizations (both 501(c)(3) and certain nonprofits without 501(c)(3) status), public and private institutions of higher education, and multiple levels of government (state, county, city/township), as well as special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government. Importantly, non-U.S. entities (foreign organizations) are allowed, and foreign (non-U.S.) components of U.S. organizations are permitted, indicating NIH openness to supporting impactful zebrafish tool development wherever the strongest capabilities exist.
The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH Grants Guide (link provided in the source: http://grants.nih.gov/grants/guide/pa-files/PAR-11-131.html). For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the grant opportunity called?
The opportunity is titled Enhancing Zebrafish Research with Research Tools and Techniques (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-11-131.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism does this use?
This funding opportunity uses the R01 research project grant mechanism.
What is the main purpose of this FOA?
The purpose is to strengthen zebrafish as a vertebrate model system for biomedical and behavioral research by funding investigator-initiated projects that create, improve, or expand research tools and techniques considered high priority by the broader zebrafish research community.
Is this opportunity focused on tool/technique development or disease-specific research?
It is centered on enabling capabilities (tools and techniques) rather than funding a single disease project in isolation. The intent is to support tools that can accelerate discovery across many fields by improving what researchers can detect, measure, manipulate, and interpret in zebrafish.
What kinds of projects are specifically encouraged?
Projects that develop or substantially advance broadly useful zebrafish tools and techniques, including approaches that improve the ability to:
- Identify genes and biological pathways
- Track cell lineages
- Visualize structures and biological activity
- Quantify behavior
- Measure physiological outputs
- Model and characterize disease-related phenotypes in zebrafish
What does NIH mean by "high priority" tools for the zebrafish community?
The FOA emphasizes tools and techniques that the broader zebrafish community considers high priority, meaning the work should aim for broad adoption and usefulness across multiple labs rather than serving a narrow, lab-specific niche.
Does the FOA support incremental improvements?
The emphasis is on meaningful increases in what can be observed, measured, or tested in zebrafish. While improvements can be part of a proposal, the FOA highlights that applications should not be limited to minor or purely incremental upgrades.
How broad is the scientific scope?
The scientific scope is intentionally wide, as long as the project is centered on zebrafish tool and technique development that enables research in areas such as development and aging, organ formation, nervous system function, neural circuits, behavior, sensory processing, physiology, and disease processes.
Why is this described as a trans-NIH initiative?
The opportunity stems from an NIH-wide initiative coordinated through the Trans-NIH Zebrafish Coordinating Committee (TZCC), co-chaired by NICHD and NIDDK, indicating multiple NIH Institutes and Centers view zebrafish tool development as shared research infrastructure.
What research areas or program domains are associated with this FOA?
The funding is associated with a broad set of CFDA program areas spanning environmental health, oral health, communication disorders, sleep, alcohol, drug abuse, cancer biology, cardiovascular and lung diseases, blood resources, diabetes/digestive/kidney research, general biomedical research and training, child health and human development, aging, and vision research.
Does the FOA prefer tools with cross-cutting value?
Yes. The description underscores that proposed tools should ideally have cross-cutting value, enabling progress across many biological and disease areas rather than serving a narrow niche.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Is this FOA currently open for applications?
No. This specific FOA is historical. It was created and posted on March 30, 2011, had an original and final closing date of September 19, 2013, and an archive date of October 20, 2013.
If it is closed, why might it still matter?
Even though it is no longer open, it can still serve as a reference for the kinds of zebrafish-focused tool development NIH has prioritized and how NIH frames community-enabling research resources.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including:
- For-profit organizations (including small businesses and other for-profits)
- Nonprofit organizations (501(c)(3) and certain nonprofits without 501(c)(3) status)
- Public and private institutions of higher education
- State, county, and city/township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible agencies of the federal government
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA explicitly allows non-U.S. entities (foreign organizations), and it also permits foreign (non-U.S.) components of U.S. organizations.
Where can the full announcement be found?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-11-131.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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