Opportunity Information: Apply for PAR 11 130
Apply for PAR 11 130
- The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "Genetic Screens to Enhance Zebrafish Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.233 National Center on Sleep Disorders Research 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Mar 30, 2011 and posted on Mar 30, 2011.
- Applicants must submit their applications by Sep 19, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The NIH funding opportunity PAR-11-130, titled "Genetic Screens to Enhance Zebrafish Research (R01)," supports investigator-initiated R01 research projects that take advantage of zebrafish as a powerful vertebrate model for biomedical and behavioral science. The central goal is to expand and strengthen the genetic screening toolkit available to the zebrafish community, with an emphasis on screens that can uncover and help characterize genes, biological pathways, and measurable phenotypes that matter for human health and fundamental biology. The program is geared toward projects that move beyond single-gene studies by creating or refining systematic approaches to discover genetic contributors to complex processes and disease-relevant traits.
A major focus of the FOA is the development of new genetic screens considered high priority for the zebrafish field. NIH signals interest in screens that advance the detection and characterization of genetic factors underlying key areas such as embryonic development and aging, organ formation and function, neural processes, behavior, sensory biology, and broader physiological and disease processes. In practical terms, the opportunity is meant to encourage proposals that can identify novel mutant phenotypes, map them to genes and pathways, and deliver insights that can be broadly useful to researchers studying conserved vertebrate biology, mechanisms of disease, or potential therapeutic targets. Because zebrafish are well suited to genetics, imaging, and large sample sizes, the FOA is aligned with approaches that can produce scalable discovery and community-wide value.
In addition to brand-new screens, the announcement explicitly welcomes pilot projects that adapt existing phenotypic screening methods to enable high-throughput characterization of mutants produced by large-scale mutagenesis efforts. This reflects an NIH interest in making sure that the growing number of zebrafish mutants generated through systematic mutagenesis can be efficiently evaluated for meaningful phenotypes. In other words, the FOA is not limited to inventing new mutagenesis strategies; it also supports efforts to modernize and scale phenotype detection pipelines, so that large mutant collections can be screened in a standardized, efficient, and informative way.
This initiative stems from a broader NIH effort coordinated through the Trans-NIH Zebrafish Coordinating Committee (TZCC), co-chaired by NICHD and NIDDK, indicating that the program is intentionally cross-cutting and relevant to multiple NIH mission areas. That cross-institute footprint is reflected in the wide range of CFDA program areas associated with the FOA, spanning fields such as environmental health, oral health, communication disorders, sleep, alcohol and substance use, cancer biology, cardiovascular and blood diseases, diabetes and digestive and kidney diseases, and child health and development. The breadth suggests NIH is looking for zebrafish screening projects that can plug into many disease and biology domains rather than a narrow niche.
From an administrative standpoint, this is a discretionary NIH grant opportunity using the R01 mechanism, with an award ceiling listed at $500,000, and no cost sharing or matching requirement. The announcement was posted March 30, 2011, with a closing date of September 19, 2013, and an archive date of October 20, 2013, meaning it is no longer active but serves as a clear example of NIH priorities for zebrafish genetics during that period. Eligibility was broad and included a wide range of organization types: public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, U.S. territories and possessions, and foreign organizations and foreign components of U.S. organizations. The FOA also notes inclusion of institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, consistent with NIH-wide policies aimed at broad participation across the research community.
Overall, PAR-11-130 is best understood as a community-focused zebrafish genetics R01: it seeks projects that build or adapt genetic and phenotypic screening strategies capable of accelerating gene and pathway discovery and improving phenotype characterization at scale. The intended payoff is stronger, more efficient zebrafish-based discovery pipelines that can illuminate vertebrate development, physiology, behavior, aging, and disease mechanisms in ways that translate across many areas of NIH-supported biomedical research.
FAQs: NIH PAR-11-130 - Genetic Screens to Enhance Zebrafish Research (R01)
What is PAR-11-130?
PAR-11-130 is an NIH funding opportunity announcement (FOA) titled "Genetic Screens to Enhance Zebrafish Research (R01)." It supports investigator-initiated R01 research projects that use zebrafish as a vertebrate model to advance biomedical and behavioral science through genetic and phenotypic screening approaches.
What is the main goal of this FOA?
The central goal is to expand and strengthen the genetic screening toolkit available to the zebrafish research community. The FOA emphasizes systematic screening strategies that can uncover and help characterize genes, biological pathways, and measurable phenotypes that are important for human health and fundamental biology.
What kinds of projects does the program prioritize?
The FOA is geared toward projects that move beyond single-gene studies by developing or refining approaches that can discover genetic contributors to complex processes and disease-relevant traits. A major priority is developing new genetic screens that the NIH considers high value for the zebrafish field.
What scientific areas are specifically highlighted as high-interest for screening?
NIH signals interest in screens that improve detection and characterization of genetic factors in areas including embryonic development and aging, organ formation and function, neural processes, behavior, sensory biology, and broader physiology and disease processes.
Does the FOA support discovering new mutant phenotypes and linking them to genes?
Yes. The opportunity is intended to encourage proposals that can identify novel mutant phenotypes, map them to genes and pathways, and generate insights that are broadly useful for studying conserved vertebrate biology, mechanisms of disease, and potential therapeutic targets.
Is this FOA only for creating brand-new screening methods?
No. In addition to brand-new screens, the announcement explicitly welcomes pilot projects that adapt existing phenotypic screening methods for high-throughput characterization of mutants produced by large-scale mutagenesis efforts.
What does NIH mean by adapting phenotypic screening methods for high-throughput use?
Based on the FOA description, this refers to modernizing and scaling phenotype detection pipelines so large mutant collections can be evaluated efficiently, in standardized ways, and with informative outputs. The emphasis is on enabling efficient screening of growing numbers of zebrafish mutants generated through systematic mutagenesis.
Why is zebrafish a good fit for this program?
The FOA frames zebrafish as a powerful vertebrate model well suited to genetics, imaging, and large sample sizes. Those strengths align with scalable screening approaches that can deliver broad discovery value to the research community.
How is this FOA positioned within NIH?
This initiative is described as part of a broader NIH effort coordinated through the Trans-NIH Zebrafish Coordinating Committee (TZCC), co-chaired by NICHD and NIDDK. That suggests the program is cross-cutting and relevant to multiple NIH mission areas rather than limited to a single institute focus.
What fields or disease areas could be relevant under this FOA?
The FOA is associated with a wide range of CFDA program areas, spanning environmental health, oral health, communication disorders, sleep, alcohol and substance use, cancer biology, cardiovascular and blood diseases, diabetes and digestive and kidney diseases, and child health and development. This breadth suggests zebrafish screening projects could connect to many domains of biology and disease.
What grant mechanism does PAR-11-130 use?
PAR-11-130 uses the NIH R01 mechanism and supports investigator-initiated research projects focused on zebrafish genetic and phenotypic screens.
What is the maximum award amount listed for this opportunity?
The award ceiling listed for this FOA is $500,000.
Is cost sharing or matching required?
No. The FOA specifies that there is no cost sharing or matching requirement.
When was this FOA posted, and is it still active?
The announcement was posted on March 30, 2011. It had a closing date of September 19, 2013, and an archive date of October 20, 2013. Based on those dates, it is no longer active.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (including small businesses); state and local governments; tribal governments and tribal organizations; U.S. territories and possessions; and foreign organizations and foreign components of U.S. organizations.
Does the FOA mention participation by specific institution types?
Yes. The FOA notes inclusion of institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities, consistent with NIH-wide policies intended to support broad participation across the research community.
What is the overall intent or payoff NIH is looking for?
Overall, PAR-11-130 is best understood as a community-focused zebrafish genetics R01 aimed at building or adapting screening strategies that accelerate gene and pathway discovery and improve phenotype characterization at scale. The intended payoff is stronger and more efficient zebrafish-based discovery pipelines that inform vertebrate development, physiology, behavior, aging, and disease mechanisms across many areas of NIH-supported research.
Browse more opportunities from the same category: Education Environment Food and Nutrition Health Income Security and Social Services
Next opportunity: Enhancing Zebrafish Research with Research Tools and Techniques (R01)
Previous opportunity: Next Generation PrEP II (R01)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 11 130) also looked into and applied for these:
| Funding Opportunity |
|---|
| Enhancing Zebrafish Research with Research Tools and Techniques (R01) Apply for PAR 11 131 Funding Number: PAR 11 131 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient Oriented Research (Parent K24) Apply for PA 11 195 Funding Number: PA 11 195 Agency: National Institutes of Health Category: Education Environment Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
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