Opportunity Information: Apply for RFA ES 11 011
Apply for RFA ES 11 011
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Environmental Influences on Stem Cells in Development, Health, and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.389 National Center for Research Resources.
- This funding opportunity was created on Sep 21, 2011 and posted on Sep 21, 2011.
- Applicants must submit their applications by Nov 28, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Independent school districts County governments Private institutions of higher education State governments Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Environmental Influences on Stem Cells in Development, Health, and Disease (R01) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-ES-11-011) designed to push research into new directions that clarify how environmental exposures can change stem cell biology. The central focus is on understanding whether, how, and under what conditions exposures in the environment can alter core stem cell behaviors such as function, proliferation (how quickly stem cells divide), survival (whether they live or undergo cell death), and differentiation (how they mature into specialized cell types). The scope explicitly includes both embryonic stem cells and adult stem cells, spanning pluripotent cells (capable of giving rise to many cell types) and multipotent cells (more restricted but still able to produce multiple related cell types). In practical terms, the initiative is geared toward uncovering mechanistic links between environmental factors and the ways stem cells contribute to normal development, lifelong health, and disease processes.
This opportunity uses the NIH R01 mechanism, which is generally intended for substantial, hypothesis-driven research projects with clearly defined aims. The activity categories associated with the announcement include education, environment, and health, reflecting the broad public-health relevance of stem cell responses to environmental influences. The program is tied to CFDA numbers 93.113 (Environmental Health) and 93.389 (National Center for Research Resources), signaling that it sits at the intersection of environmental health science and biomedical research capacity. The announcement states there is no cost sharing or matching requirement, which means applicants are not required to provide institutional or third-party funds as a condition of receiving the award.
From a funding and timing standpoint, the posted and creation date for the announcement was September 21, 2011. The original and current closing date were both November 28, 2011, and the archive date was December 29, 2011, indicating that this specific solicitation is no longer active but remains important as a reference point for the kinds of projects NIH has sought to stimulate in this area. The estimated total funding listed is $2,500,000, which represents the anticipated overall pool available under the initiative rather than a guaranteed amount per award.
Eligibility is broad and spans many organizational types, reflecting NIH's interest in attracting diverse scientific perspectives and institutional strengths. Eligible applicants include small businesses and other for-profit organizations (other than small businesses), nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status, other than institutions of higher education), and a wide range of public-sector entities such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities. Educational institutions are also eligible, including private institutions of higher education, public and state-controlled institutions of higher education, and independent school districts. The eligibility section further highlights additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, along with regional organizations and U.S. territories or possessions. Notably, non-U.S. entities (foreign institutions) are eligible to apply, although non-U.S. components of U.S. organizations are not eligible; at the same time, foreign components are allowed as defined by the NIH Grants Policy Statement, which typically means certain project elements can be conducted abroad when justified and compliant with NIH rules.
The official agency behind the opportunity is the NIH, and the announcement provides an additional information link hosted on the NIH grants site. For access or technical issues, the provided point of contact is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), which is specifically meant to help applicants who have trouble retrieving the full announcement or linking to it online.
Overall, this R01 initiative was structured to catalyze research that connects environmental exposures to changes in stem cell behavior, with implications for understanding how environmental factors can influence development and contribute to disease risk or progression through effects on stem cell populations.
Frequently Asked Questions (FAQs)
What is the "Environmental Influences on Stem Cells in Development, Health, and Disease (R01)" opportunity?
It is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-ES-11-011) intended to stimulate research that clarifies how environmental exposures can change stem cell biology and, in turn, influence development, health across the lifespan, and disease processes.
Which agency sponsors this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What funding mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which is generally intended for substantial, hypothesis-driven research projects with clearly defined aims.
What is the main scientific focus of the funding opportunity?
The central focus is understanding whether, how, and under what conditions environmental exposures can alter core stem cell behaviors, including function, proliferation (division rate), survival (living versus undergoing cell death), and differentiation (maturing into specialized cell types).
What kinds of stem cells are within the scope of this opportunity?
The scope explicitly includes both embryonic stem cells and adult stem cells, spanning pluripotent cells (capable of giving rise to many cell types) and multipotent cells (more restricted but still able to produce multiple related cell types).
What types of research outcomes is NIH trying to stimulate with this solicitation?
The initiative is geared toward uncovering mechanistic links between environmental factors and how stem cells contribute to normal development, lifelong health, and disease processes.
Which activity categories are associated with this announcement?
The activity categories listed include education, environment, and health, reflecting the broad public-health relevance of how stem cells respond to environmental influences.
What CFDA numbers are associated with this opportunity?
The announcement is tied to CFDA 93.113 (Environmental Health) and CFDA 93.389 (National Center for Research Resources).
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement, meaning applicants are not required to provide institutional or third-party funds as a condition of receiving an award.
What is the estimated total funding amount listed for the initiative?
The estimated total funding listed is $2,500,000. This represents the anticipated overall pool available under the initiative rather than a guaranteed amount per award.
When was this funding opportunity posted?
The posted and creation date for the announcement was September 21, 2011.
What were the closing dates for applications?
The original closing date and the current closing date were both November 28, 2011.
Is this funding opportunity still active?
No. The archive date was December 29, 2011, indicating this specific solicitation is no longer active, though it may still be useful as a reference for the kinds of projects NIH sought to stimulate in this area.
Who is eligible to apply?
Eligibility is broad and includes small businesses; other for-profit organizations (other than small businesses); nonprofit organizations (including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status, other than institutions of higher education); and many public-sector entities such as state, county, city or township governments, special district governments, and public housing authorities/Indian housing authorities. Educational institutions are eligible as well, including private institutions of higher education, public and state-controlled institutions of higher education, and independent school districts.
Are minority-serving institutions and community-based organizations eligible?
Yes. The eligibility section highlights Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, as well as regional organizations and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. Non-U.S. entities (foreign institutions) are eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. The announcement states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed on a project?
Yes. The opportunity notes that foreign components are allowed as defined by the NIH Grants Policy Statement, which generally means certain project elements can be conducted abroad when justified and compliant with NIH rules.
Where can applicants find the official announcement or additional information?
The announcement includes an additional information link hosted on the NIH grants site.
Who should be contacted for access or technical issues with the announcement link?
For access or technical issues retrieving the full announcement or linking to it online, the provided contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the Funding Opportunity Number for this solicitation?
The Funding Opportunity Number is RFA-ES-11-011.
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Previous opportunity: Environmental Influences on Stem Cells in Development, Health, and Disease (R21)
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 11 011) also looked into and applied for these:
| Funding Opportunity |
|---|
| Interventions for Health Promotion and Disease Prevention in Native American Populations (R01) Apply for PAR 11 346 Funding Number: PAR 11 346 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 12 003 Funding Number: RFA ES 12 003 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (R01) Apply for PAR 12 010 Funding Number: PAR 12 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $250,000 |
| NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U01) Apply for PAR 12 011 Funding Number: PAR 12 011 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $500,000 |
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Etiology, Diagnosis, Pathophysiology, and Treatment (R21) Apply for PAR 12 033 Funding Number: PAR 12 033 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Environmental Exposures and Health Exploration of Non Traditional Settings, (R21) Apply for PA 12 134 Funding Number: PA 12 134 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Environmental Exposures and Health Exploration of Non Traditional Settings, (R01) Apply for PA 12 133 Funding Number: PA 12 133 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Research to Action Assessing and Addressing Community Exposures to Environmental Contaminants (R01) Apply for PA 12 153 Funding Number: PA 12 153 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $500,000 |
| TaRGET I Chromatin Structure, Genomics, and Transcriptional Responses to the Environment (R01) Apply for RFA ES 12 008 Funding Number: RFA ES 12 008 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $400,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 13 001 Funding Number: RFA ES 13 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Superfund Research Program Occupational and Safety Training Education Programs on Emerging Technologies (R25) Apply for RFA ES 13 004 Funding Number: RFA ES 13 004 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $250,000 |
| NLM Administrative Supplements for Informationist Services in NIH funded Research Projects (Admin Supp) Apply for PA 13 276 Funding Number: PA 13 276 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Biogeochemical Interactions Affecting Bioavailability for in situ Remediation of Hazardous Substances (R01) Apply for RFA ES 13 010 Funding Number: RFA ES 13 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $150,000 |
| Analysis of Genome Wide Gene Environment (G x E) Interactions (R21) Apply for PAR 13 382 Funding Number: PAR 13 382 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 001 Funding Number: RFA ES 14 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellowship (Parent F33) Apply for PA 14 151 Funding Number: PA 14 151 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Administrative Supplements for the U.S. Japan Brain Research Cooperative Program (BRCP) U.S. Entity (Administrative Supplement) Apply for PA 14 249 Funding Number: PA 14 249 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 007 Funding Number: RFA ES 14 007 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Interventions for Health Promotion and Disease Prevention in Native American Populations (R01) Apply for PAR 14 260 Funding Number: PAR 14 260 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) Research (U01) Apply for RFA TW 14 001 Funding Number: RFA TW 14 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $600,000 |
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