Opportunity Information: Apply for RFA ES 11 010
Apply for RFA ES 11 010
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Environmental Influences on Stem Cells in Development, Health, and Disease (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.389 National Center for Research Resources 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Oct 24, 2011 and posted on Sep 21, 2011.
- Applicants must submit their applications by Nov 28, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Special district governments Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Environmental Influences on Stem Cells in Development, Health, and Disease (R21) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-ES-11-010) designed to spark early-stage, high-impact research on how environmental exposures can affect stem cell biology. The central aim is to encourage novel research directions that clarify whether, how, and under what conditions environmental factors alter stem cell function, including their proliferation, survival, and differentiation. The scope explicitly includes both embryonic and adult stem cell populations, spanning pluripotent and multipotent cells, with the broader intent of linking environmental influences on stem cells to outcomes relevant to development, lifelong health, and disease processes.
This opportunity uses the NIH R21 mechanism, which is commonly geared toward exploratory and developmental projects where strong innovation is expected, but where preliminary data may be limited or still emerging. Within that spirit, the initiative focuses on uncovering new concepts, methods, and mechanistic insights about environmental impacts on stem cells rather than funding large, mature programmatic efforts. The emphasis on “environmental exposures†reflects an interest in external factors that may include chemical, physical, biological, or other environment-related stressors that could disrupt or reprogram stem cell behavior, potentially shaping tissue formation, repair capacity, aging trajectories, or disease susceptibility.
The funding details indicate an estimated total program funding level of $1,000,000, with an award ceiling of $200,000. There is no cost sharing or matching requirement. The Funding Instrument Type is a grant, and the listed activity categories include education, environment, and health, aligning with NIH interests in environmental health research and its downstream implications for human biology and disease prevention. The CFDA numbers associated with the announcement include 93.113 (Environmental Health), 93.389 (National Center for Research Resources), and 93.393 (Cancer Cause and Prevention Research), signaling that the research themes are relevant not only to general environmental health but also to core research resources and cancer-related prevention and etiology questions, where stem cell dysregulation can be an important underlying mechanism.
A wide range of applicants are eligible. Eligible entities include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and those without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government such as city or township governments, county governments, state governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal eligibility is broad as well, including federally recognized Native American tribal governments and tribal organizations that are not federally recognized. The announcement also highlights eligibility for institutions and organizations that serve specific communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, as well as regional organizations and U.S. territories or possessions.
The opportunity also allows non-U.S. participation in a specific way: non-domestic (non-U.S.) entities (foreign institutions) are eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are allowed. However, non-domestic components of U.S. organizations are not eligible to apply. This structure supports international collaboration and expertise when it strengthens the science, while maintaining particular administrative boundaries for U.S.-based organizations operating abroad.
Key dates show the announcement was posted on September 21, 2011, created on October 24, 2011, and had an original and current closing date of November 28, 2011, with an archive date of December 29, 2011. While the program is archived and therefore not open under those dates, the content remains useful as a blueprint for the kinds of exploratory, mechanistic, environmentally focused stem cell studies NIH has sought to catalyze under the R21 mechanism.
Additional details and the full announcement were made available through the NIH Grants Guide webpage associated with the RFA (http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-11-010.html). For technical access issues, the provided point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, specifically for difficulties accessing the announcement or linking to it.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Environmental Influences on Stem Cells in Development, Health, and Disease (R21).
What agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-ES-11-010.
What is the main goal of this RFA?
The central aim is to spark early-stage, high-impact research that clarifies whether, how, and under what conditions environmental factors alter stem cell function, including effects on stem cell proliferation, survival, and differentiation, and how those changes relate to development, lifelong health, and disease.
What research topics are within the scope of this opportunity?
The scope focuses on environmental impacts on stem cell biology and function, with an emphasis on mechanistic insight and new approaches. It specifically includes how environmental factors may disrupt or reprogram stem cell behavior in ways that could influence tissue formation, repair capacity, aging trajectories, or disease susceptibility.
Which types of stem cells are included?
The scope explicitly includes both embryonic and adult stem cell populations, spanning pluripotent and multipotent cells.
What does NIH mean by “environmental exposures†in this announcement?
The announcement signals interest in external environmental factors that may include chemical, physical, biological, or other environment-related stressors that could affect stem cell behavior.
What funding mechanism is used?
This opportunity uses the NIH R21 mechanism, which is typically intended for exploratory and developmental research projects.
Is this opportunity intended for early-stage or exploratory work?
Yes. The R21 mechanism is commonly geared toward early-stage, exploratory projects where innovation is expected and preliminary data may be limited or still emerging.
Is this opportunity meant to support large, mature program efforts?
No. The stated emphasis is on uncovering new concepts, methods, and mechanistic insights rather than supporting large, mature, programmatic efforts.
What is the estimated total program funding level?
The estimated total program funding level listed is $1,000,000.
What is the award ceiling?
The award ceiling is listed as $200,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What is the funding instrument type?
The funding instrument type is a grant.
What activity categories are associated with this opportunity?
The listed activity categories include education, environment, and health.
What CFDA numbers are associated with the announcement?
The CFDA numbers listed are 93.113 (Environmental Health), 93.389 (National Center for Research Resources), and 93.393 (Cancer Cause and Prevention Research).
What do the listed CFDA numbers suggest about the focus areas?
They indicate the research themes are relevant to environmental health, core research resources, and cancer cause and prevention, including areas where stem cell dysregulation may be an underlying mechanism.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government.
Which government entities are eligible?
Eligible government entities include city or township governments, county governments, state governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments and also tribal organizations that are not federally recognized.
Are institutions serving specific communities explicitly included?
Yes. The announcement highlights eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, as well as regional organizations and U.S. territories or possessions.
Can foreign (non-U.S.) organizations apply?
Yes. The opportunity states that non-domestic (non-U.S.) entities (foreign institutions) are eligible to apply.
Are foreign components allowed under this opportunity?
Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed.
Are non-domestic components of U.S. organizations eligible to apply?
No. The announcement states that non-domestic components of U.S. organizations are not eligible to apply.
When was this opportunity posted?
The announcement was posted on September 21, 2011.
When was the record created?
The record shows it was created on October 24, 2011.
What were the closing date and archive date?
The original and current closing date was November 28, 2011, and the archive date was December 29, 2011.
Is this funding opportunity currently open?
No. It is described as archived and therefore not open under the listed dates.
Where can the full announcement be found?
The full announcement was made available through the NIH Grants Guide webpage at: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-11-010.html.
Who should be contacted for technical issues accessing the announcement link?
For difficulties accessing the announcement or linking to it, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants who have applied for this opportunity (RFA ES 11 010) also looked into and applied for these:
| Funding Opportunity |
|---|
| Environmental Influences on Stem Cells in Development, Health, and Disease (R01) Apply for RFA ES 11 011 Funding Number: RFA ES 11 011 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Interventions for Health Promotion and Disease Prevention in Native American Populations (R01) Apply for PAR 11 346 Funding Number: PAR 11 346 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 12 003 Funding Number: RFA ES 12 003 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (R01) Apply for PAR 12 010 Funding Number: PAR 12 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $250,000 |
| NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U01) Apply for PAR 12 011 Funding Number: PAR 12 011 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $500,000 |
| Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Etiology, Diagnosis, Pathophysiology, and Treatment (R21) Apply for PAR 12 033 Funding Number: PAR 12 033 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Environmental Exposures and Health Exploration of Non Traditional Settings, (R21) Apply for PA 12 134 Funding Number: PA 12 134 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Environmental Exposures and Health Exploration of Non Traditional Settings, (R01) Apply for PA 12 133 Funding Number: PA 12 133 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Research to Action Assessing and Addressing Community Exposures to Environmental Contaminants (R01) Apply for PA 12 153 Funding Number: PA 12 153 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $500,000 |
| TaRGET I Chromatin Structure, Genomics, and Transcriptional Responses to the Environment (R01) Apply for RFA ES 12 008 Funding Number: RFA ES 12 008 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $400,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 13 001 Funding Number: RFA ES 13 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Superfund Research Program Occupational and Safety Training Education Programs on Emerging Technologies (R25) Apply for RFA ES 13 004 Funding Number: RFA ES 13 004 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $250,000 |
| NLM Administrative Supplements for Informationist Services in NIH funded Research Projects (Admin Supp) Apply for PA 13 276 Funding Number: PA 13 276 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Biogeochemical Interactions Affecting Bioavailability for in situ Remediation of Hazardous Substances (R01) Apply for RFA ES 13 010 Funding Number: RFA ES 13 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $150,000 |
| Analysis of Genome Wide Gene Environment (G x E) Interactions (R21) Apply for PAR 13 382 Funding Number: PAR 13 382 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 001 Funding Number: RFA ES 14 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellowship (Parent F33) Apply for PA 14 151 Funding Number: PA 14 151 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Administrative Supplements for the U.S. Japan Brain Research Cooperative Program (BRCP) U.S. Entity (Administrative Supplement) Apply for PA 14 249 Funding Number: PA 14 249 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 007 Funding Number: RFA ES 14 007 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Interventions for Health Promotion and Disease Prevention in Native American Populations (R01) Apply for PAR 14 260 Funding Number: PAR 14 260 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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