Opportunity Information: Apply for RFA NR 10 005
Apply for RFA NR 10 005
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Epigenetic Factors Associated with Symptoms and Complications of Chronic Disorders (Competitive Revision R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Mar 8, 2010 and posted on Mar 8, 2010.
- Applicants must submit their applications by May 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $750,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Epigenetic Factors Associated with Symptoms and Complications of Chronic Disorders (Competitive Revision R01)" (Funding Opportunity Number RFA-NR-10-005) is a National Institutes of Health (NIH) funding announcement led by the National Institute of Nursing Research (NINR). Its central goal is to push forward research on how epigenetic mechanisms (biological changes that affect gene activity without changing the underlying DNA sequence) may shape how people experience symptoms and develop complications when living with chronic disorders. The intent is strongly translational in spirit: NINR is looking for studies that can clarify why symptom severity and downstream complications vary so much from person to person, and how that knowledge can be used to improve identification of risk, guide symptom management strategies, and ultimately reduce or even prevent complications that emerge over time.
The scientific purpose is framed around three practical outcomes. First, the research is expected to help identify which individuals are most likely to develop severe symptoms or serious secondary complications associated with chronic conditions. Second, it aims to improve symptom management by grounding interventions and clinical decision-making in a better understanding of the underlying epigenetic contributors to symptom expression. Third, it targets the longer-term burden of chronic disorders by supporting work that could reduce, prevent, or potentially reverse complications, implying an interest in actionable biological pathways and markers that can be monitored, modified, or used to tailor care. While the announcement does not list specific chronic diseases, the wording suggests broad applicability to chronic disorders where symptoms and complications are persistent, complex, and variable across patients.
In terms of mechanism, this is not a standard new R01. It uses the Competitive Revision mechanism, meaning the application is intended as an expansion or significant modification of an already funded, active project rather than an entirely new stand-alone award. Competitive revisions are typically used when investigators can justify a major new direction, added aims, or substantial new work that builds on the parent grant. NINR also notes that this opportunity runs in parallel with a separate announcement of the same scientific scope (RFA-NR-10-004) that supports applications through the traditional R01 pathway, so applicants needed to choose the route that matches their situation: competitive revision for an eligible existing award versus a new R01 for a new project.
Funding for this announcement was limited and targeted. NIH committed an estimated total of $750,000 for fiscal year 2010 under this FOA, with an expectation of funding roughly 2 to 3 competitive revision awards. That combination of a relatively small total pot and a low number of anticipated awards signals a competitive program designed to seed a small number of high-impact projects rather than fund a broad portfolio.
The administrative details place the program within NIH’s nursing research CFDA listing (93.361, Nursing Research). There is no cost-sharing or matching requirement, which aligns with typical NIH research grant structure. The opportunity was posted and created on March 8, 2010, with an original and current closing date of May 17, 2010, and an archive date of June 17, 2010. In other words, it was a time-limited call for applications for that cycle and is now archived.
Eligibility was broad and inclusive, spanning many types of organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, and small businesses, along with a wide range of government entities (state governments, county governments, city/township governments, and special district governments). The eligibility language also explicitly included numerous institution types and communities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other tribal organizations, including federally recognized tribal governments. It also allowed non-U.S. (foreign) organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and faith-based or community-based organizations, reflecting NIH’s general openness to diverse organizational applicants when scientifically justified.
For applicants needing the full official announcement, NIH provided a link to the archived NIH Guide RFA page (http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-10-005.html). Technical access and linking issues were routed to the NIH Office of Extramural Research (OER) webmaster contact listed in the announcement.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Epigenetic Factors Associated with Symptoms and Complications of Chronic Disorders (Competitive Revision R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-NR-10-005.
Which agency and institute lead this funding announcement?
This is a National Institutes of Health (NIH) funding announcement led by the National Institute of Nursing Research (NINR).
What is the central goal of this funding opportunity?
The central goal is to advance research on how epigenetic mechanisms (biological changes that affect gene activity without changing the DNA sequence) may influence symptom experiences and the development of complications in people living with chronic disorders.
What does "epigenetic mechanisms" mean in the context of this FOA?
In this FOA, epigenetic mechanisms refer to biological changes that can alter gene activity without changing the underlying DNA sequence, and that may help explain differences in symptom severity and complication risk across individuals with chronic conditions.
What kind of research approach is NINR looking for?
The FOA is strongly translational in spirit. It emphasizes studies that clarify why symptoms and complications vary from person to person and how that knowledge could be used to improve risk identification, guide symptom management, and reduce, prevent, or potentially reverse complications over time.
What practical outcomes does the FOA emphasize?
The scientific purpose is framed around three outcomes: (1) identifying individuals most likely to develop severe symptoms or serious secondary complications, (2) improving symptom management by grounding interventions and decisions in epigenetic contributors to symptom expression, and (3) reducing, preventing, or potentially reversing complications by focusing on actionable pathways and markers.
Does the FOA specify particular chronic diseases?
No. The announcement does not list specific chronic diseases. The wording suggests broad applicability to chronic disorders with persistent, complex symptoms and complications that vary across patients.
Is this a standard new R01 application?
No. This opportunity uses the Competitive Revision mechanism for an R01, meaning it is intended as an expansion or significant modification of an already funded, active project rather than a new stand-alone award.
What is meant by "Competitive Revision" in this announcement?
A Competitive Revision application generally proposes a major new direction, added aims, or substantial new work that builds on an active parent grant. This FOA is specifically for that type of expansion to an existing funded project.
Is there another related FOA for applicants who do not have an eligible parent award?
Yes. NINR noted that this opportunity runs in parallel with another announcement of the same scientific scope (RFA-NR-10-004) that supports applications through the traditional R01 pathway.
How much funding was available through this FOA?
NIH committed an estimated total of $750,000 for fiscal year 2010 under this FOA.
How many awards were expected to be made?
The FOA anticipated funding roughly 2 to 3 competitive revision awards.
What does the limited number of expected awards suggest about competitiveness?
With a relatively small total funding amount and an expectation of only 2 to 3 awards, the program appears designed to support a small number of high-impact projects and would likely be competitive.
What CFDA program listing is associated with this opportunity?
The opportunity is within NIH's nursing research CFDA listing 93.361 (Nursing Research).
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
When was this FOA posted and created?
It was posted and created on March 8, 2010.
What was the application closing date?
The original and current closing date listed was May 17, 2010.
Is the opportunity still open?
No. The FOA is archived. It also lists an archive date of June 17, 2010, indicating it was a time-limited call for that cycle.
What types of organizations were eligible to apply?
Eligibility was broad and included public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, small businesses, and many government entities (state, county, city/township, and special district governments).
Were minority-serving institutions and tribal organizations included in eligibility?
Yes. The eligibility language explicitly included HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other tribal organizations, including federally recognized tribal governments.
Could foreign (non-U.S.) organizations apply?
Yes. The eligibility language allowed non-U.S. (foreign) organizations, as well as regional organizations, U.S. territories or possessions, eligible federal agencies, and faith-based or community-based organizations.
Where can someone find the official archived announcement?
The FOA referenced the archived NIH Guide RFA page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-10-005.html
Who was listed for technical access or link issues?
Technical access and linking issues were routed to the NIH Office of Extramural Research (OER) webmaster contact listed in the announcement.
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