Opportunity Information: Apply for RFA NR 10 004
Apply for RFA NR 10 004
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Epigenetic Factors Associated with Symptoms and Complications of Chronic Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Mar 8, 2010 and posted on Mar 8, 2010.
- Applicants must submit their applications by May 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,250,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This funding opportunity, issued by the National Institutes of Health through the National Institute of Nursing Research (NINR), supports research on how epigenetic mechanisms contribute to the way symptoms show up and how complications develop in people living with chronic disorders. The core idea is to move beyond describing symptoms and complications and instead investigate the underlying epigenetic factors that may help explain why some individuals experience more severe symptom burdens, faster progression, or more frequent and serious secondary complications than others. The expectation is that results from projects funded under this announcement will improve the ability to spot individuals at highest risk, tailor and strengthen symptom management approaches, and ultimately reduce, prevent, or potentially reverse complications associated with chronic conditions.
The award uses the NIH R01 mechanism, meaning it is intended for substantial, hypothesis-driven research projects rather than small pilots. The announcement also notes that it runs alongside a companion opportunity with the same scientific scope (RFA NR 10 005) that focuses on the Competitive Revision mechanism, which is typically aimed at adding a significant new component to an already funded project. In practice, this R01 version is geared toward investigators proposing a full standalone study centered on epigenetic contributors to symptom expression and complication risk in chronic disorders.
For fiscal year 2010, NINR committed an estimated total of $1.25 million to this opportunity, with an anticipated 2 to 3 R01 awards expected to be made. There is no cost sharing or matching requirement, which aligns with standard NIH grant practice and reduces administrative and financial barriers for applicants.
Eligibility is broad and includes many types of organizations that commonly participate in NIH research. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government such as state, county, city or township, and special district governments. The eligibility language also explicitly includes a wide set of additional entities, such as federally recognized and other tribal governments and tribal organizations, tribally controlled colleges and universities (TCCUs), historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and even non-U.S. entities (foreign organizations). This wide eligibility suggests NINR wanted to encourage participation from diverse research settings and communities, which is often important for symptom science and chronic disorder research where population differences and social context can shape outcomes.
Key administrative details place this as a time-limited, archived opportunity from 2010. The Funding Opportunity Number is RFA NR 10 004, it was posted March 8, 2010, and the application deadline (original and current closing date) was May 17, 2010, with an archive date of June 17, 2010. The CFDA number associated with this program is 93.361 (Nursing Research), and the activity category is listed under education and health, reflecting NINR's nursing science mission and the focus on improving health outcomes through better understanding and management of symptoms and complications.
In plain terms, the announcement was designed to push the field toward identifying epigenetic signatures or processes that help explain variability in symptom severity and downstream complications in chronic illness, with a practical end goal: better risk stratification, better symptom control, and fewer long-term complications. The full announcement was hosted on the NIH grants site at: http://grants.nih.gov/grants/guide/rfa files/RFA NR 10 004.html, and NIH provided standard support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity issued through the National Institute of Nursing Research (NINR) to support research on how epigenetic mechanisms contribute to (1) how symptoms present and vary across individuals and (2) how complications develop in people living with chronic disorders.
What is the main goal of the research supported by this opportunity?
The focus is on moving beyond describing symptoms and complications to investigating the underlying epigenetic factors that may explain why some individuals experience higher symptom burden, faster progression, or more frequent/serious secondary complications than others.
What outcomes are expected from projects funded under this announcement?
The expectation is that funded projects will improve the ability to identify individuals at highest risk, tailor and strengthen symptom management approaches, and ultimately reduce, prevent, or potentially reverse complications associated with chronic conditions.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which is intended for substantial, hypothesis-driven research projects rather than small pilot studies.
Is there a related or companion funding opportunity?
Yes. The announcement notes a companion opportunity with the same scientific scope (RFA NR 10 005) that focuses on the Competitive Revision mechanism, which is generally used to add a significant new component to an already funded project.
How is this R01 version different from the companion Competitive Revision option?
Based on the information provided, the R01 version is aimed at investigators proposing a full standalone study centered on epigenetic contributors to symptom expression and complication risk in chronic disorders, whereas the Competitive Revision version targets expansions to existing funded projects.
How much funding did NINR plan to commit to this opportunity?
For fiscal year 2010, NINR committed an estimated total of $1.25 million to this opportunity.
How many awards were anticipated?
The opportunity anticipated making 2 to 3 R01 awards.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (including state, county, city or township, and special district governments).
Are tribal entities eligible to apply?
Yes. The eligibility language explicitly includes federally recognized and other tribal governments and tribal organizations, as well as tribally controlled colleges and universities (TCCUs).
Are minority-serving institutions eligible?
Yes. The eligibility language explicitly includes historically black colleges and universities (HBCUs), Hispanic-serving institutions, and Alaska Native and Native Hawaiian-serving institutions.
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are explicitly included in the eligibility list.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly included as eligible entities.
Are federal agencies eligible to apply?
Yes. The eligibility language includes eligible federal agencies.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility language explicitly includes non-U.S. entities (foreign organizations).
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA NR 10 004.
When was the opportunity posted?
It was posted on March 8, 2010.
What was the application deadline?
The application deadline (original and current closing date) was May 17, 2010.
Is this opportunity still open?
No. The opportunity is described as time-limited and archived. The archive date was June 17, 2010.
What is the CFDA number associated with this program?
The CFDA number associated with this program is 93.361 (Nursing Research).
What activity category is associated with this opportunity?
The activity category is listed under education and health.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site at: http://grants.nih.gov/grants/guide/rfa_files/RFA_NR_10_004.html
Who provides support for access or linking issues to the announcement?
NIH provided standard support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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Previous opportunity: Epigenetic Factors Associated with Symptoms and Complications of Chronic Disorders (Competitive Revision R01)
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