Opportunity Information: Apply for PA 13 003
Apply for PA 13 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epigenetic Inheritance and Transgenerational Effects of Alcohol (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Oct 3, 2012 and posted on Oct 3, 2012.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Private institutions of higher education Public and State controlled institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Epigenetic Inheritance and Transgenerational Effects of Alcohol (R01) opportunity (Funding Opportunity Number PA-13-003) was a National Institutes of Health funding announcement issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to support full-scale Research Project Grant (R01) studies focused on how alcohol exposure can produce biological and health effects that persist across generations. The core emphasis is on mechanistic work, meaning projects are expected to move beyond describing associations and instead test how alcohol-related changes are transmitted and maintained, using rigorous experimental approaches in humans and/or animal models. A central theme is epigenetic inheritance, including alcohol-induced alterations in epigenetic regulation that could plausibly explain why offspring or later descendants show measurable changes even when they were not directly exposed to alcohol themselves.
In practical terms, the FOA sought projects that investigate transgenerational effects linked to alcohol and identify the underlying epigenetic mechanisms that could mediate these outcomes. This includes studying how alcohol exposure may modify epigenetic marks or regulatory processes (for example, changes in DNA methylation, histone modifications, chromatin structure, and noncoding RNA regulation) in germ cells or early developmental stages, and how those changes might influence gene expression and downstream phenotypes in subsequent generations. The announcement explicitly encouraged use of both human studies and animal models, reflecting an intent to combine clinical relevance with the experimental control needed to establish causality, timing, tissue specificity, and biological pathways.
The funding mechanism was an R01 research grant, placed within the NIH health-related research activity category, and aligned with CFDA 93.273 (Alcohol Research Programs). It was categorized as discretionary funding and did not require cost sharing or matching, which is typical for NIH research project grants. The announcement was posted and created on October 3, 2012, with an original and final application due date listed as May 7, 2016, and it was archived on June 7, 2016, indicating the program is no longer open under that specific announcement.
Eligibility was broad and inclusive of a wide range of domestic and international research organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district). The FOA also allowed applications from tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and other organizations as described in the NIH eligibility text. In addition, the opportunity explicitly recognized eligibility for a range of institution types often highlighted in federal research programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations. Importantly, non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, foreign components were permitted as defined by the NIH Grants Policy Statement, and non-U.S. components of U.S. organizations could participate, making the scope of potential applicants global.
For applicants seeking more detail at the time, NIH provided an official listing and full text of the announcement via an NIH grants URL, and included contact points for technical access issues through the NIH Office of Extramural Research (OER) webmaster email. Overall, the opportunity was designed to accelerate well-powered, mechanism-driven research that clarifies whether and how alcohol exposure can produce heritable epigenetic changes, and how those changes might translate into measurable biological, behavioral, or disease-related outcomes across generations.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH Funding Opportunity Announcement (FOA) titled "The Epigenetic Inheritance and Transgenerational Effects of Alcohol (R01)" with Funding Opportunity Number PA-13-003. It was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).
What was the main purpose of PA-13-003?
The FOA was designed to support full-scale Research Project Grant (R01) studies that examine how alcohol exposure can lead to biological and health effects that persist across generations. A major goal was to clarify whether alcohol can produce heritable changes and to explain those effects through underlying epigenetic mechanisms.
What type of grant mechanism was used?
The funding mechanism was an NIH Research Project Grant (R01), intended for full-scale research projects.
Which NIH institute issued the announcement?
The FOA was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
Is this FOA still accepting applications?
No. The FOA is no longer open under this specific announcement. It was archived on June 7, 2016, and the original and final application due date listed was May 7, 2016.
When was the FOA posted?
The announcement was posted (and created) on October 3, 2012.
What scientific emphasis did the FOA prioritize?
The core emphasis was mechanistic research. Projects were expected to move beyond describing associations and instead test how alcohol-related changes are transmitted and maintained across generations using rigorous experimental approaches.
What does "mechanistic work" mean in the context of this FOA?
In this FOA, mechanistic work refers to studies that directly test biological processes and pathways that could explain transgenerational outcomes, rather than only reporting correlations. The intent was to use strong experimental designs to assess causality, timing, tissue specificity, and underlying biological pathways.
What is meant by "transgenerational effects of alcohol" in this announcement?
Transgenerational effects refer to measurable biological, behavioral, or disease-related outcomes in offspring or later descendants that persist across generations, including scenarios where later generations were not directly exposed to alcohol themselves.
What role did epigenetic inheritance play in the FOA?
Epigenetic inheritance was a central theme. The FOA focused on alcohol-induced alterations in epigenetic regulation that could plausibly explain why effects might be observed in subsequent generations.
What kinds of epigenetic mechanisms were specifically mentioned?
The FOA highlighted several examples of epigenetic regulation and marks that could be studied, including DNA methylation, histone modifications, chromatin structure, and noncoding RNA regulation.
What biological materials or developmental windows were of interest?
The FOA explicitly pointed to germ cells and early developmental stages as important contexts for studying how alcohol exposure may modify epigenetic marks or regulatory processes that could influence later generations.
Were both human studies and animal models allowed?
Yes. The FOA explicitly encouraged the use of both human studies and animal models, reflecting an interest in combining clinical relevance with experimental control.
Why did the FOA encourage combining human and animal research approaches?
Based on the FOA description, the rationale was to pair clinical relevance (human studies) with the experimental control available in animal models to better establish causality, timing, tissue specificity, and biological pathways.
What kinds of outcomes were projects expected to connect to epigenetic changes?
Projects were intended to connect alcohol-related epigenetic changes to downstream gene expression and resulting phenotypes in subsequent generations, including biological, behavioral, or disease-related outcomes.
What CFDA program was this FOA aligned with?
The FOA was aligned with CFDA 93.273, Alcohol Research Programs.
Was the funding discretionary or mandatory?
It was categorized as discretionary funding.
Did the FOA require cost sharing or matching funds?
No. The FOA did not require cost sharing or matching, which is typical for NIH research project grants.
Who was eligible to apply?
Eligibility was broad and included a wide range of domestic and international research organizations. Eligible applicants included public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and multiple levels of government (state, county, city/township, special district).
Were tribal governments and tribal organizations eligible?
Yes. The FOA allowed applications from tribal governments and tribal organizations.
Could public housing authorities or Indian housing authorities apply?
Yes. Public housing authorities and Indian housing authorities were listed among eligible applicant types.
Were independent school districts eligible applicants?
Yes. Independent school districts were included in the eligibility description.
Were faith-based or community-based organizations eligible?
Yes. The eligibility language explicitly recognized faith-based and community-based organizations among institution types often highlighted in federal research programs.
Were certain minority-serving institutions called out as eligible?
Yes. The FOA explicitly recognized eligibility for institution types including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Could non-U.S. (foreign) organizations apply directly?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply.
Were foreign components allowed under this FOA?
Yes. Foreign components were permitted as defined by the NIH Grants Policy Statement.
Could non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations could participate, making the scope of potential applicants global.
Where could applicants find the official FOA text when it was active?
NIH provided an official listing and the full text of the announcement via an NIH grants URL referenced in the opportunity information.
Who was listed for help with technical access issues?
For technical access issues, the NIH Office of Extramural Research (OER) provided a webmaster email contact point.
What was the overall research goal of the announcement?
The overall goal was to accelerate well-powered, mechanism-driven research to clarify whether and how alcohol exposure can produce heritable epigenetic changes and how those changes might translate into measurable outcomes across generations.
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