Opportunity Information: Apply for PA 13 004
Apply for PA 13 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epigenetic Inheritance and Transgenerational Effects of Alcohol (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Oct 3, 2012 and posted on Oct 3, 2012.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Small businesses Special district governments Public and State controlled institutions of higher education County governments Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Epigenetic Inheritance and Transgenerational Effects of Alcohol (R21) funding opportunity (PA-13-004) was a discretionary National Institutes of Health grant announcement issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to support early-stage, exploratory research on how alcohol exposure can produce effects that persist across generations. The central focus was on identifying and testing epigenetic mechanisms that might transmit alcohol-related biological or behavioral changes from parents to offspring, including true transgenerational outcomes where effects are observed beyond directly exposed individuals. The FOA explicitly encouraged studies using both human subjects and animal models, reflecting an interest in combining mechanistic work in controlled systems with observational or translational work relevant to human health.
As an R21 Exploratory/Developmental Research Grant, the program was designed for high-impact ideas and proof-of-concept projects rather than large, long-term research programs. The R21 mechanism generally emphasizes innovation, feasibility, and the ability to generate preliminary data that can justify later, more extensive applications. In practical terms, applicants were expected to propose tightly scoped studies that could clarify whether alcohol exposure is linked to heritable epigenetic alterations (for example, changes in DNA methylation, histone modifications, chromatin structure, or non-coding RNA profiles) and whether those alterations are plausibly connected to measurable outcomes in descendants. Projects could include investigations of germline and somatic epigenetic marks, developmental timing of exposure, and how inherited epigenetic states might influence brain development, stress responsivity, metabolism, or risk for alcohol use problems.
The opportunity fell under the health funding activity category and mapped to CFDA 93.273 (Alcohol Research Programs). The announcement stated there was no cost sharing or matching requirement. The listed award ceiling was $200,000, indicating the maximum amount permitted under this particular posting. The FOA was posted on October 3, 2012, and remained open through a closing date of May 7, 2016, with an archive date of June 7, 2016, meaning it is no longer active for new submissions.
Eligibility was broad and included many types of U.S. organizations and governmental entities, as well as foreign organizations and components where allowed under NIH policy. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities (state, county, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The eligibility list also covered tribal governments (federally recognized) and other tribal organizations, and explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and eligible federal agencies. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed as defined by the NIH Grants Policy Statement.
The announcement’s practical intent was to push the field toward clearer evidence about whether alcohol exposure can leave epigenetic signatures that are not only detectable but also biologically meaningful across generations, and to stimulate development of models, assays, and analytic approaches that can separate direct exposure effects from inherited ones. Applicants were directed to the full FOA text hosted by NIH for complete requirements and scientific priorities (http://grants.nih.gov/grants/guide/pa-files/PA-13-004.html). For technical issues accessing or linking to the announcement, the contact provided was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Epigenetic Inheritance and Transgenerational Effects of Alcohol (R21) and is identified as PA-13-004.
Which agency and institute issued this announcement?
This was a discretionary National Institutes of Health (NIH) grant announcement issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main scientific focus of PA-13-004?
The central focus was early-stage, exploratory research on how alcohol exposure can produce effects that persist across generations, with an emphasis on identifying and testing epigenetic mechanisms that might transmit alcohol-related biological or behavioral changes from parents to offspring.
What does "transgenerational" mean in the context of this FOA?
In this FOA, "true transgenerational outcomes" refers to effects that are observed beyond directly exposed individuals, meaning changes seen in descendants who were not themselves directly exposed to the alcohol exposure being studied.
What grant mechanism was used, and what does it imply about project scope?
This used the R21 Exploratory/Developmental Research Grant mechanism. It was designed for high-impact ideas and proof-of-concept projects rather than large, long-term research programs, with a practical emphasis on innovation, feasibility, and generating preliminary data to support future, more extensive applications.
What types of studies were encouraged (human vs. animal)?
The FOA explicitly encouraged studies using both human subjects and animal models, reflecting interest in combining mechanistic work in controlled systems with observational or translational work relevant to human health.
What kinds of epigenetic mechanisms were within scope?
Examples of epigenetic alterations mentioned as relevant included DNA methylation, histone modifications, chromatin structure, and non-coding RNA profiles.
What kinds of biological materials or targets could be studied?
Projects could include investigations of germline and somatic epigenetic marks, along with consideration of the developmental timing of alcohol exposure.
What types of outcomes in descendants were considered relevant?
The FOA described outcomes potentially influenced by inherited epigenetic states, including effects on brain development, stress responsivity, metabolism, and risk for alcohol use problems.
What was the broader intent or motivation of the program?
The announcement aimed to push the field toward clearer evidence about whether alcohol exposure can leave epigenetic signatures that are detectable and biologically meaningful across generations, and to stimulate development of models, assays, and analytic approaches that can help separate direct exposure effects from inherited effects.
What is the CFDA number and funding activity category?
The opportunity mapped to CFDA 93.273 (Alcohol Research Programs) and fell under the health funding activity category.
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement.
What was the award ceiling under this posting?
The listed award ceiling was $200,000, indicating the maximum amount permitted under this particular posting.
When was the FOA posted, and is it still open?
The FOA was posted on October 3, 2012 and remained open through a closing date of May 7, 2016. It had an archive date of June 7, 2016, meaning it is no longer active for new submissions.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations and governmental entities, and also included foreign organizations and components where allowed under NIH policy. Eligible applicants included:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations (including small businesses and other for-profits)
- Government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities)
- Tribal governments (federally recognized) and other tribal organizations
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-Serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- U.S. territories or possessions
- Regional organizations
- Eligible federal agencies
Were non-U.S. (foreign) organizations eligible?
Yes. Foreign organizations and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed as defined by the NIH Grants Policy Statement.
Where can applicants find the full FOA text?
The announcement directed applicants to the full FOA text hosted by NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-13-004.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact provided was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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