Opportunity Information: Apply for W81XWH 12 CRMRP RTR

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Restorative Transplantation Research (RTR) Cooperative Agreement" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Oct 3, 2012 and posted on Oct 3, 2012.
  • Applicants must submit their applications by Dec 5, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $13,750,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:

The Restorative Transplantation Research (RTR) Cooperative Agreement is a Fiscal Year 2012 funding opportunity from the Department of Defense (through the Defense Health Program Research and Development Office and administered by the U.S. Army Medical Research Acquisition Activity). Its main purpose is to support innovative, high-impact research that can meaningfully improve function, wellness, and overall quality of life for injured military Service members and veterans, as well as their caregivers, family members, and ultimately the broader public. The program is positioned within a science and technology research and development context and targets restorative transplantation, a field also referred to as reconstructive composite tissue allotransplantation or vascularized composite allotransplantation, which includes complex transplants involving multiple tissue types.

A central theme of the opportunity is accelerating progress in a maturing field by pushing for new directions and addressing gaps or neglected issues in restorative transplantation research. While the program explicitly seeks bold and potentially practice-changing ideas, it also makes clear that proposals must be grounded in a solid scientific rationale rather than being purely speculative. The announcement emphasizes laboratory-focused research with a strong translational intent, meaning projects should be designed to move promising findings toward real clinical use rather than remaining isolated in preclinical exploration.

The program places special value on work that can modify, restructure, or otherwise improve clinical practice guidelines for restorative transplantation. It also prioritizes research approaches that can be rapidly integrated into clinical practice, reflecting a sense of urgency around improving care for patients with severe injuries. Applicants are encouraged to draw from the mature infrastructure of solid organ transplantation, particularly in areas like standardizing protocols and processes, suggesting that the funder is interested not only in new discoveries but also in improving consistency, safety, and scalability across restorative transplantation programs.

Collaboration is strongly encouraged and is treated as a key mechanism for impact. The opportunity calls for multi-institutional and multidisciplinary partnerships that bring clinicians and basic scientists together to speed translation into clinical applications. Proposals involving the military Services are highlighted as especially welcome, and collaborations spanning academia, industry, the Department of Veterans Affairs, and other federal agencies are explicitly encouraged. The cooperative agreement mechanism also signals that the government anticipates an active role in coordination and oversight compared to a standard grant, with the intent of aligning funded work closely to program goals and facilitating progress toward deliverables that matter for patient care.

In terms of who can apply, eligibility is described as unrestricted, meaning a wide range of entity types may apply as long as they meet any additional eligibility notes contained in the full announcement. There is no cost sharing or matching requirement, lowering barriers for applicants who may not have non-federal funds to contribute. The opportunity anticipated a small number of awards (expected awards: 1) with a relatively large total funding level for the program cycle (estimated total funding: $13,750,000), implying a preference for a substantial, coordinated effort rather than many small, disconnected projects.

The announcement also encourages applicants to leverage already funded restorative transplantation procedures as platforms for investigating other parts of the knowledge base, which reflects a practical emphasis on building efficiently from existing clinical activity and infrastructure. Applicants are further encouraged to show a portfolio of research projects spanning a range of development stages, suggesting the program values a pipeline approach that can include nearer-term clinical translation alongside earlier-stage foundational work, as long as the overall plan is coherent and positioned for significant impact in restorative transplantation.

Key administrative details include the funding opportunity number W81XWH-12-CRMRP-RTR, a posting date of October 3, 2012, and an original/current closing date of December 5, 2012, with an archive date of January 4, 2013. The CFDA listing is 12.420 (Military Medical Research and Development). For access issues or help with the announcement, the contact provided is the CDMRP Help Desk at help@cdmrp.org or 301-682-5507.

Restorative Transplantation Research (RTR) Cooperative Agreement - FAQs

1) What is the Restorative Transplantation Research (RTR) Cooperative Agreement?

The RTR Cooperative Agreement is a Fiscal Year 2012 funding opportunity from the Department of Defense, through the Defense Health Program Research and Development Office, administered by the U.S. Army Medical Research Acquisition Activity. It supports research intended to advance restorative transplantation and improve outcomes for injured military Service members and veterans.

2) What is the main goal of this funding opportunity?

The main goal is to support innovative, high-impact research that can meaningfully improve function, wellness, and overall quality of life for injured Service members and veterans, as well as their caregivers and family members, with potential benefit to the broader public.

3) What research area does the RTR program focus on?

The RTR program targets restorative transplantation, also referred to as reconstructive composite tissue allotransplantation or vascularized composite allotransplantation. This includes complex transplants involving multiple tissue types.

4) What kinds of ideas is the program looking for?

The opportunity emphasizes bold, potentially practice-changing directions that help accelerate progress in a maturing field. At the same time, proposals are expected to be grounded in a solid scientific rationale and not be purely speculative.

5) Is this opportunity focused on laboratory research or clinical research?

The announcement emphasizes laboratory-focused research with strong translational intent. Projects should be designed to move promising findings toward real clinical use, rather than remaining isolated within preclinical exploration.

6) What does "translational intent" mean in the context of this program?

Based on the announcement, translational intent means designing research so that results can be moved toward clinical application in restorative transplantation, with a focus on practical impact rather than only generating early-stage findings.

7) Does the program prioritize changes to clinical practice?

Yes. The program places special value on research that can modify, restructure, or otherwise improve clinical practice guidelines for restorative transplantation, and it prioritizes approaches that can be rapidly integrated into clinical practice.

8) Does the opportunity encourage using existing solid organ transplant infrastructure?

Yes. Applicants are encouraged to draw from the mature infrastructure of solid organ transplantation, including efforts to standardize protocols and processes, reflecting interest in consistency, safety, and scalability in restorative transplantation programs.

9) Is collaboration required or just encouraged?

Collaboration is strongly encouraged and treated as a key mechanism for impact. The announcement calls for multi-institutional and multidisciplinary partnerships that bring clinicians and basic scientists together to speed translation into clinical applications.

10) Are partnerships with military organizations encouraged?

Yes. Proposals involving the military Services are highlighted as especially welcome.

11) What other types of collaborations are encouraged?

The opportunity explicitly encourages collaborations spanning academia, industry, the Department of Veterans Affairs, and other federal agencies.

12) What does it mean that this is a "cooperative agreement"?

The cooperative agreement mechanism signals that the government anticipates an active role in coordination and oversight compared to a standard grant. The intent is to align funded work closely to program goals and to help facilitate progress toward deliverables that matter for patient care.

13) Who is eligible to apply?

Eligibility is described as unrestricted, meaning a wide range of entity types may apply, as long as they meet any additional eligibility notes contained in the full announcement.

14) Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

15) How many awards are expected?

The opportunity anticipated a small number of awards, with expected awards listed as 1.

16) What is the estimated total funding available?

The estimated total funding for the program cycle is $13,750,000.

17) What does the combination of one expected award and a large funding level suggest?

It implies a preference for a substantial, coordinated effort rather than many small, disconnected projects.

18) Does the announcement encourage building on existing restorative transplantation procedures?

Yes. Applicants are encouraged to leverage already funded restorative transplantation procedures as platforms for investigating other parts of the knowledge base, reflecting an emphasis on building efficiently from existing clinical activity and infrastructure.

19) Does the program favor a single project or a portfolio approach?

The announcement encourages applicants to present a portfolio of research projects spanning a range of development stages, suggesting the program values a pipeline approach that may include nearer-term clinical translation alongside earlier-stage foundational work, as long as the overall plan is coherent and positioned for significant impact.

20) What is the funding opportunity number?

The funding opportunity number is W81XWH-12-CRMRP-RTR.

21) What is the CFDA listing for this opportunity?

The CFDA listing is 12.420 (Military Medical Research and Development).

22) When was the opportunity posted?

The posting date is October 3, 2012.

23) What was the closing date for applications?

The original/current closing date listed is December 5, 2012.

24) When was the opportunity archived?

The archive date is January 4, 2013.

25) Who do applicants contact for help or access issues?

For access issues or help with the announcement, the contact provided is the CDMRP Help Desk at help@cdmrp.org or 301-682-5507.

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