Opportunity Information: Apply for RFA DE 13 002
Apply for RFA DE 13 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epigenomics of Virus Associated Oral Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Oct 31, 2012 and posted on Oct 31, 2012.
- Applicants must submit their applications by Feb 21, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Small businesses For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities State governments County governments Special district governments Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Epigenomics of Virus Associated Oral Diseases (R01) opportunity (Funding Opportunity Number RFA-DE-13-002) is a discretionary NIH research grant solicitation from the National Institute of Dental and Craniofacial Research (NIDCR). It was designed to support full-scale, hypothesis-driven R01 projects that push forward the understanding of how epigenetic and epigenomic changes contribute to oral diseases in which viral infection plays a meaningful role. The central aim is not just to describe correlations, but to generate mechanistic evidence that clarifies how epigenomic regulation in both the virus and the host drives disease processes, with the longer-term expectation that this knowledge can be translated into new epigenomics-informed clinical approaches for prevention, diagnosis, or treatment.
The scientific focus is on the epigenetic basis of virus-associated oral diseases, meaning applicants are expected to examine epigenomic modifications that affect gene activity without changing the underlying DNA sequence. The announcement emphasizes two main expectations. First, studies should discover and clearly define mechanisms of action of epigenomic modifications in both viral epigenomes and host epigenomes. This includes identifying what specific modifications occur, how they are established or maintained, and which molecular pathways or regulatory proteins are involved. Second, projects should demonstrate how these epigenomic alterations lead to pathophysiological changes in oral cells and tissues that culminate in oral disease. Importantly, the FOA also flags that these oral infection-related epigenomic changes may contribute to disease beyond the oral cavity, so research that clarifies systemic consequences or links to conditions in other parts of the body is within scope when biologically justified.
From a practical standpoint, this is an R01 mechanism, which generally signals support for substantial multi-year research plans with rigorous experimental design, strong preliminary rationale, and a clear path to meaningful biological or clinical insight. The FOA frames epigenomic investigation as a gateway to intervention, so competitive applications would typically be expected to move beyond descriptive profiling and connect epigenomic observations to functional outcomes, disease-relevant phenotypes, and actionable targets or biomarkers. While the announcement text provided does not list specific required methods, the emphasis on mechanisms and causality implies that applications would be most responsive when they include experimental strategies that can test function, not only measure marks, such as linking epigenomic states to changes in transcriptional programs, cellular behavior, tissue pathology, or host-virus interactions in oral contexts.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, for-profit entities (including those other than small businesses), and a wide range of government entities such as state, county, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal organizations and tribal governments (federally recognized and other than federally recognized), as well as mission-focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are included, and the announcement allows non-U.S. entities to apply: foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations may participate, and foreign components are allowed under NIH policy. There is no cost sharing or matching requirement.
Key administrative details indicate the FOA was posted on October 31, 2012, with an original and current closing date of February 21, 2013, and an archive date of March 24, 2013. The activity category is health, and the associated CFDA number is 93.121 (Oral Diseases and Disorders Research). Additional official information was provided through the NIH Grants Guide link (RFA-DE-13-002), and the NIH Office of Extramural Research webmaster contact was listed for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Epigenomics of Virus Associated Oral Diseases (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DE-13-002.
Which agency and NIH institute offered this grant?
This is an NIH research grant solicitation offered by the National Institute of Dental and Craniofacial Research (NIDCR).
What type of grant mechanism is this?
This opportunity uses the R01 mechanism and is described as supporting full-scale, hypothesis-driven research projects.
What is the main goal of the FOA?
The central goal is to advance understanding of how epigenetic and epigenomic changes contribute to oral diseases where viral infection plays a meaningful role, with an emphasis on producing mechanistic evidence (not just correlations).
What kinds of diseases or conditions are in scope?
The focus is on virus-associated oral diseases, meaning oral diseases for which viral infection is a meaningful factor. The FOA also notes that infection-related epigenomic changes may contribute to disease beyond the oral cavity, so biologically justified systemic links are within scope.
What does the FOA mean by "epigenetic" or "epigenomic" changes?
It refers to epigenomic modifications that affect gene activity without changing the underlying DNA sequence.
Is the FOA looking for descriptive studies, mechanistic studies, or both?
The FOA emphasizes moving beyond describing correlations. It prioritizes mechanistic evidence explaining how epigenomic regulation in both the virus and the host drives disease processes.
What are the two main scientific expectations highlighted in the announcement?
First, projects should discover and clearly define mechanisms of action of epigenomic modifications in both viral and host epigenomes (what modifications occur, how they are established/maintained, and which pathways or regulatory proteins are involved). Second, projects should demonstrate how these epigenomic alterations lead to pathophysiological changes in oral cells and tissues that culminate in oral disease.
Does the FOA require studying both the viral epigenome and the host epigenome?
The announcement explicitly emphasizes mechanisms in both viral epigenomes and host epigenomes, indicating that responsiveness is aligned with addressing both sides when scientifically relevant.
Are systemic (non-oral) impacts allowed as part of the research scope?
Yes. The FOA flags that oral infection-related epigenomic changes may contribute to disease beyond the oral cavity, and research that clarifies systemic consequences or links to conditions elsewhere in the body is within scope when biologically justified.
What makes an application competitive based on the information provided?
Based on the announcement text, competitive applications would typically be expected to move beyond profiling and connect epigenomic observations to functional outcomes, including disease-relevant phenotypes and potentially actionable targets or biomarkers, consistent with the FOA's emphasis on mechanism and causality.
Does the FOA specify required methods or technologies?
No specific required methods are listed in the information provided. However, the emphasis on mechanisms and causality implies that proposed strategies should be able to test function, not only measure epigenomic marks, for example by linking epigenomic states to transcriptional programs, cellular behavior, tissue pathology, or host-virus interactions in oral contexts.
What is the longer-term translational expectation of this research?
The FOA states a longer-term expectation that mechanistic epigenomics knowledge can be translated into new epigenomics-informed clinical approaches for prevention, diagnosis, or treatment.
What is the activity category associated with this opportunity?
The activity category is health.
What is the CFDA number for this program?
The associated CFDA number is 93.121 (Oral Diseases and Disorders Research).
When was the FOA posted?
The FOA was posted on October 31, 2012.
What was the closing date for applications?
The original and current closing date listed is February 21, 2013.
When was the FOA archived?
The archive date is March 24, 2013.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, for-profit entities (including those other than small businesses), and many types of government entities (state; county; city/township; special district; independent school districts; and public housing authorities/Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal organizations and tribal governments (federally recognized and other than federally recognized).
Are mission-focused institution types (such as HBCUs or HSIs) eligible?
Yes. The FOA explicitly includes institutions such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based and community-based organizations eligible?
Yes. The FOA states that faith-based and community-based organizations are included.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA allows foreign organizations and foreign institutions to apply. It also allows non-U.S. components of U.S. organizations to participate, and foreign components are allowed under NIH policy.
Where can applicants find the official listing or additional details?
The FOA references the NIH Grants Guide listing for RFA-DE-13-002 as the official source of additional information.
Who was listed as a contact for access or linking issues?
The information provided indicates the NIH Office of Extramural Research webmaster was listed for access or linking issues.
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