Opportunity Information: Apply for RFA DE 13 003
Apply for RFA DE 13 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epigenomics of Virus Associated Oral Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Oct 31, 2012 and posted on Oct 31, 2012.
- Applicants must submit their applications by Feb 21, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Small businesses State governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of Dental and Craniofacial Research (NIDCR) released this discretionary grant opportunity, titled "Epigenomics of Virus Associated Oral Diseases (R21)" (Funding Opportunity Number RFA-DE-13-003), to encourage innovative studies on how epigenetic changes contribute to oral diseases that are linked to viral infection. The core goal is to move beyond simply identifying viral presence and instead explain how viruses and oral tissues interact at the epigenome level, with the longer-term intent of pointing toward new epigenomics-based clinical interventions. Although the description text also mentions R01 applications in places, the opportunity title and mechanism are R21, which typically supports exploratory, early-stage projects that may be higher risk but could deliver high impact.
The scientific focus centers on two main expectations. First, applicants are expected to discover and clearly define mechanisms by which epigenomic modifications operate in both the viral epigenome and the host (human) epigenome. This includes understanding how epigenetic marks and chromatin regulation influence viral behavior (such as latency, persistence, or reactivation) and how infection alters host gene regulation in oral cells. Second, proposed studies should connect those epigenomic modifications to real biological consequences by demonstrating how changes in either the host or viral epigenome drive pathological changes in oral cells and tissues that lead to oral disease. The FOA also emphasizes that these processes may have relevance beyond the mouth, meaning projects can reasonably address systemic effects when the oral viral-epigenomic interaction contributes to disease in other parts of the body.
The award uses the NIH R21 mechanism, which is designed to fund exploratory research, proof-of-concept work, and the early stages of unconventional or emerging ideas. The FOA frames this as support for high-risk, high-impact efforts that could open new directions or extend previous findings into more innovative territory. Consistent with an R21, the listed award ceiling is $200,000, and there is no cost sharing or matching requirement.
Administratively, the opportunity falls under the health funding activity category and is associated with CFDA number 93.121 (Oral Diseases and Disorders Research). It was posted and created on October 31, 2012, with an original and current closing date of February 21, 2013, and an archive date of March 24, 2013. The sponsoring agency is the National Institutes of Health, specifically NIDCR.
Eligibility is broad and includes many domestic organization types such as small businesses, for-profit organizations (including those other than small businesses), nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), public and private institutions of higher education, and multiple levels of government (state, county, city/township, special district), as well as public housing authorities and tribal governments and organizations. The FOA explicitly includes a wide range of mission- and community-based eligible institutions, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions, along with faith-based or community-based organizations and eligible federal agencies. Importantly, foreign participation is allowed: non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are permitted.
For applicants needing the full text and requirements, the FOA is linked through the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-13-003.html). For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Epigenomics of Virus Associated Oral Diseases (R21) (RFA-DE-13-003)
What is the name of this grant opportunity?
The opportunity is titled "Epigenomics of Virus Associated Oral Diseases (R21)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DE-13-003.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), specifically the National Institute of Dental and Craniofacial Research (NIDCR).
What is the main purpose of this FOA?
The FOA encourages innovative studies that explain how epigenetic and epigenomic changes contribute to oral diseases linked to viral infection. A key goal is to move beyond simply detecting viruses and instead clarify how viruses and oral tissues interact at the epigenome level, with the longer-term aim of informing epigenomics-based clinical interventions.
What research mechanism does this FOA use?
This FOA uses the NIH R21 mechanism, which is typically intended for exploratory, early-stage projects that can be higher risk but potentially high impact.
The text mentions R01 in places. Is this an R01 or an R21?
Based on the information provided, the opportunity title and mechanism are R21. Even though the description text references R01 applications in places, the FOA as described here is an R21 opportunity.
What kind of projects is the R21 mechanism intended to support?
R21s are designed to support exploratory research, proof-of-concept work, and early investigations of unconventional or emerging ideas. This FOA frames the R21 as support for high-risk, high-impact efforts that may open new directions or extend previous findings in more innovative ways.
What scientific areas or questions does the FOA emphasize?
The FOA emphasizes epigenomics in virus-associated oral diseases, focusing on how epigenetic marks and chromatin regulation influence both viral behavior and host (human) gene regulation in oral tissues during infection.
What are the two main scientific expectations described in the FOA?
First, applicants are expected to discover and clearly define mechanisms by which epigenomic modifications operate in both the viral epigenome and the host epigenome (including how epigenetic marks and chromatin regulation affect viral latency, persistence, or reactivation, and how infection alters host gene regulation in oral cells). Second, studies should connect those epigenomic modifications to biological consequences by demonstrating how changes in either the host or viral epigenome drive pathological changes in oral cells and tissues that lead to oral disease.
Does the FOA focus only on identifying whether a virus is present?
No. A core goal is to move beyond simply identifying viral presence and instead explain mechanisms of virus-host interaction at the epigenome level and how those mechanisms contribute to disease.
Can proposed work address viral latency, persistence, or reactivation?
Yes. The FOA specifically includes understanding how epigenetic marks and chromatin regulation influence viral behavior such as latency, persistence, or reactivation.
Does the FOA require linking epigenomic changes to actual disease biology?
Yes. The FOA emphasizes demonstrating how epigenomic changes in the host or virus lead to pathological changes in oral cells and tissues that result in oral disease.
Can projects include systemic (beyond the mouth) relevance?
Yes. The FOA notes that the processes may have relevance beyond the mouth, so projects may reasonably address systemic effects when oral viral-epigenomic interactions contribute to disease elsewhere in the body.
What is the funding ceiling for this R21 award?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the funding activity category?
The opportunity falls under the health funding activity category.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.121 (Oral Diseases and Disorders Research).
When was the opportunity posted?
It was posted (and created) on October 31, 2012.
What are the closing and archive dates listed for this FOA?
The original and current closing date is February 21, 2013, and the archive date is March 24, 2013.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types, such as small businesses; for-profit organizations (including those other than small businesses); nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); public and private institutions of higher education; and multiple levels of government (state, county, city/township, special district). It also includes public housing authorities and tribal governments and organizations, as well as eligible federal agencies.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The FOA explicitly includes institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions. It also includes faith-based or community-based organizations.
Is foreign participation allowed?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) may apply. Non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are permitted.
Where can applicants find the full FOA text and requirements?
The FOA is linked through the NIH grants site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-13-003.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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