Opportunity Information: Apply for PA 09 255
Apply for PA 09 255
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Erythropoiesis Components and Mechanisms (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research 93.866 Aging Research.
- This funding opportunity was created on Aug 14, 2009 and posted on Aug 14, 2009.
- Applicants must submit their applications by Sep 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts City or township governments Small businesses Special district governments State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Erythropoiesis Components and Mechanisms (R01) funding opportunity (PA 09-255) is an NIH investigator-initiated research grant program focused on advancing a deeper, more complete understanding of erythropoiesis, meaning the biological process by which red blood cells are produced and mature. It is jointly issued by three NIH institutes, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). The core intent is to encourage hypothesis-driven R01 projects that use erythroid cells as the experimental system and that aim to identify, map, and explain the molecular and cellular building blocks that make erythropoiesis work.
A central theme of the announcement is building a comprehensive picture of the "components" of erythropoiesis and the "mechanisms" that connect those components to functional outcomes. The FOA highlights two broad categories of components. First are genes expressed in erythroid cells, including how gene expression changes across developmental stages or during erythroid differentiation, which is framed in terms of defining the erythroid transcriptome. Second are proteins produced in erythroid cells, with particular interest in the erythroid proteome and features that are distinctive in red cell development, such as post-translational modifications and subcellular localization patterns that may be unique or unusually important in erythroid lineage cells. In practical terms, the program is looking for projects that do more than catalog parts; it is emphasizing mechanistic, testable ideas about how specific genes, proteins, pathways, and signals actually drive red cell development and maturation.
The longer-range goal described in the FOA is to generate a concise, unifying description of erythropoiesis that integrates genetics, intracellular molecular processes, and cytokine determinants that influence erythroid lineages. This integrated understanding is positioned as a foundation for future therapeutic progress, especially for developing new ways to measure, prevent, or treat anemia. In other words, the scientific motivation is basic and mechanistic, but with a clear translational rationale: better mechanistic maps of erythropoiesis should ultimately make it easier to identify drug targets, biomarkers, or intervention points relevant to red blood cell disorders and anemia.
The mechanism of support is the standard NIH Research Project Grant (R01), meaning applicants propose a defined research plan that is reviewed through NIH peer review and, if funded, supports a multi-year program of hypothesis-driven research. The FOA does not set a single fixed budget or project period across all awards. Instead, it notes that award size and duration will vary depending on what is scientifically proposed and justified, and that the total dollars and number of awards will depend on the number of applications received, their quality, the requested durations, and the proposed costs. No cost sharing or matching is required.
In terms of who can apply, eligibility is broad and includes many types of organizations. Eligible applicants include nonprofit organizations (including 501(c)(3) and non-501(c)(3) nonprofits), public and private institutions of higher education, small businesses, and various levels of government entities (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities. The FOA also explicitly includes a range of institution types and communities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), and tribal governments and tribal organizations. It also lists non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions as eligible, indicating the program was open to a wide set of research performers as long as they could carry out the proposed erythroid-focused research.
Key administrative details from the source listing include the opportunity category (discretionary), the funding instrument (grant), and the activity area (health). The relevant CFDA program areas are 93.839 (Blood Diseases and Resources Research) and 93.866 (Aging Research), which aligns with the involvement of NHLBI and NIA and the clinical relevance of anemia across the lifespan. The opportunity was posted on August 14, 2009, and the original and current closing dates were September 7, 2012, after which it was archived (archive date October 8, 2012). The full announcement was hosted on the NIH grants website under the PA 09-255 program announcement page, and the contact listed for access or linking issues was the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs) - Erythropoiesis Components and Mechanisms (R01) (PA 09-255)
What is the Erythropoiesis Components and Mechanisms (R01) funding opportunity (PA 09-255)?
PA 09-255 is an NIH investigator-initiated research grant opportunity using the R01 mechanism. It focuses on advancing a deeper, more complete understanding of erythropoiesis, the biological process by which red blood cells are produced and mature.
What does "erythropoiesis" mean in the context of this opportunity?
In this announcement, erythropoiesis refers to the full developmental and maturation process of red blood cell (erythroid) lineage cells, including the molecular and cellular events that drive differentiation and functional outcomes.
Which NIH institutes jointly issued this FOA?
This program announcement was jointly issued by three NIH institutes: the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI).
What is the main goal of PA 09-255?
The central aim is to support hypothesis-driven R01 projects that use erythroid cells as the experimental system and that identify, map, and explain the molecular and cellular components of erythropoiesis and the mechanisms that connect those components to how red blood cells develop and mature.
Is the FOA looking for descriptive "parts lists" or mechanistic studies?
The emphasis is on mechanistic, testable ideas. While the FOA highlights identifying genes and proteins in erythroid cells, it also stresses going beyond cataloging by explaining how specific genes, proteins, pathways, and signals drive red cell development and maturation.
What types of "components" of erythropoiesis are highlighted?
The FOA highlights two broad categories: (1) genes expressed in erythroid cells, including changes across developmental stages and during differentiation (defining the erythroid transcriptome), and (2) proteins produced in erythroid cells, including the erythroid proteome and distinctive features of red cell development such as post-translational modifications and subcellular localization patterns.
What is meant by the "erythroid transcriptome" in this announcement?
It refers to defining and understanding gene expression in erythroid cells, including how expression patterns change across developmental stages or during erythroid differentiation.
What is meant by the "erythroid proteome" in this announcement?
It refers to proteins produced in erythroid cells, with interest in protein-level features that may be distinctive or particularly important in erythroid lineage cells, including post-translational modifications and subcellular localization.
What longer-range outcome does the FOA describe?
The longer-range goal is to generate a concise, unifying description of erythropoiesis that integrates genetics, intracellular molecular processes, and cytokine determinants that influence erythroid lineages.
How does this basic research focus connect to human health?
Although the focus is basic and mechanistic, the FOA frames this integrated understanding as a foundation for future therapeutic progress, especially for developing new ways to measure, prevent, or treat anemia.
What is the mechanism of support?
The support mechanism is the NIH Research Project Grant (R01), which funds a defined, hypothesis-driven research plan that is reviewed through NIH peer review.
Does the FOA specify a fixed budget or project period for awards?
No. The FOA states that award size and duration will vary based on what is proposed and scientifically justified. Total dollars and the number of awards depend on the number of applications received, their quality, the requested durations, and proposed costs.
Is cost sharing or matching required?
No cost sharing or matching is required.
What is the opportunity category, funding instrument, and activity area?
The opportunity category is discretionary, the funding instrument is a grant, and the activity area is health.
Which organizations are eligible to apply?
Eligibility is broad and includes nonprofit organizations (501(c)(3) and non-501(c)(3)), public and private institutions of higher education, small businesses, and government entities at multiple levels (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities.
Are specific institution types and communities explicitly included as eligible applicants?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), tribal governments, and tribal organizations.
Are non-U.S. (foreign) entities eligible?
Yes. The eligibility list includes non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions.
What CFDA program areas are associated with this opportunity?
The CFDA program areas listed are 93.839 (Blood Diseases and Resources Research) and 93.866 (Aging Research).
When was this opportunity posted and when did it close?
The opportunity was posted on August 14, 2009. The original and current closing dates were September 7, 2012.
Is this FOA still active?
No. The listing indicates the opportunity was archived, with an archive date of October 8, 2012.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website under the PA 09-255 program announcement page.
Who is listed as the contact for access or linking issues?
The contact listed for access or linking issues was the NIH Office of Extramural Research (OER) webmaster.
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