Opportunity Information: Apply for PAR 13 379
Apply for PAR 13 379
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Oct 23, 2013 and posted on Oct 23, 2013.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The grant opportunity titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R01)" (Funding Opportunity Number PAR-13-379) was issued by the National Institutes of Health under the Oral Diseases and Disorders Research program (CFDA 93.121). It is a discretionary, investigator-initiated research grant mechanism using the NIH R01 funding instrument, meaning it is aimed at supporting substantive, multi-year research projects that can produce broadly useful tools and evidence for the field. The central purpose of this announcement is to improve how clinical studies in oral and craniofacial health measure outcomes by supporting the development and refinement of outcome measures that are scientifically solid and ready for use in research settings.
At its core, this opportunity focuses on building "well founded outcome measures" for clinical studies involving oral and craniofacial diseases and conditions. In practical terms, that means creating or strengthening the tools used to evaluate whether an intervention, disease progression, or clinical change has truly occurred and how meaningful that change is. The announcement places particular emphasis on establishing the reliability and validity of these measures. Reliability refers to whether an outcome measure produces consistent results when applied repeatedly or by different raters under similar conditions, while validity addresses whether the measure actually captures what it claims to measure and supports accurate interpretation in clinical research. Projects supported under this FOA are therefore expected to go beyond proposing a new metric and instead generate the empirical evidence needed to justify its use, interpretability, and reproducibility in clinical studies.
This type of work is especially important in oral and craniofacial research because many conditions involve complex functional, structural, and patient-experienced impacts that are not always captured well by traditional clinical endpoints. Strong outcome measures can include clinician-reported assessments, imaging-based measures, laboratory-based indicators, performance-based functional tests, and patient-reported outcomes, as long as the project is centered on building the evidence base that makes those outcomes credible and usable in clinical trials and other human studies. By emphasizing rigorous measurement development, the FOA is designed to help the field standardize endpoints, improve comparability across studies, and reduce ambiguity in interpreting clinical results. Over time, stronger outcome measures can increase confidence in study findings, support regulatory or clinical decision-making, and make it easier to pool or compare data across different sites, populations, and intervention types.
The eligibility rules are broad and include many U.S.-based organization types that commonly conduct health research. Eligible applicants include public and state-controlled and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), including those other than universities), small businesses, for-profit organizations other than small businesses, and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. While eligibility is expansive within the United States and its territories, the announcement clearly excludes non-U.S. entities: foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
From an administrative standpoint, the FOA was posted on October 23, 2013, with an original and final closing date of September 7, 2015, and it was archived on October 8, 2015. It does not require cost sharing or matching, which is consistent with many NIH research project grants and lowers the barrier for institutions that may not have discretionary funds to contribute. The official NIH posting and full announcement details were provided through the NIH grants guide, and applicants experiencing access or linking issues were directed to contact the NIH Office of Extramural Research (OER) webmaster.
Overall, PAR-13-379 was structured to strengthen the foundation of clinical research in oral and craniofacial health by funding the rigorous development, testing, and validation of outcome measures. The intent is not simply to encourage more clinical studies, but to ensure that future studies are built on endpoints that are dependable, interpretable, and scientifically defensible, ultimately improving the quality and impact of evidence generated across oral and craniofacial diseases and conditions.
FAQs: Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R01) (PAR-13-379)
What is the title of this grant opportunity?
The opportunity is titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-13-379.
Which agency issued this funding opportunity?
This funding opportunity was issued by the National Institutes of Health (NIH).
What program area is this opportunity associated with?
It is associated with the Oral Diseases and Disorders Research program.
What is the CFDA number listed for this opportunity?
The CFDA number is 93.121.
What type of grant mechanism does this FOA use?
This is a discretionary, investigator-initiated research grant opportunity using the NIH R01 funding instrument.
What does the NIH R01 funding instrument generally support in this FOA?
In this FOA, the R01 mechanism is described as supporting substantive, multi-year research projects intended to produce broadly useful tools and evidence for the field.
What is the central purpose of PAR-13-379?
The central purpose is to improve how clinical studies in oral and craniofacial health measure outcomes by supporting the development and refinement of outcome measures that are scientifically solid and ready for use in research settings.
What does the FOA mean by "well founded outcome measures"?
It refers to outcome measures for clinical studies of oral and craniofacial diseases and conditions that are backed by rigorous scientific development and testing, including evidence that supports their reliability, validity, interpretability, and reproducibility for use in clinical research.
What kinds of projects are expected under this FOA?
Projects are expected to develop or refine outcome measures and, importantly, generate the empirical evidence needed to justify their use and interpretation in clinical studies, rather than simply proposing a new metric without supporting evidence.
What is meant by reliability in the context of outcome measures?
Reliability refers to whether an outcome measure produces consistent results when applied repeatedly or when used by different raters under similar conditions.
What is meant by validity in the context of outcome measures?
Validity addresses whether the measure actually captures what it claims to measure and supports accurate interpretation in clinical research.
Why does this FOA emphasize reliability and validity?
The FOA emphasizes reliability and validity because outcome measures must be dependable and scientifically defensible to reduce ambiguity in interpreting clinical results and to strengthen confidence in study findings across oral and craniofacial research.
What types of outcome measures can be supported under this FOA?
The FOA indicates that strong outcome measures may include clinician-reported assessments, imaging-based measures, laboratory-based indicators, performance-based functional tests, and patient-reported outcomes, as long as the project focuses on building a credible evidence base for their use in clinical research.
Is this FOA intended to fund clinical trials or mainly measurement development?
Based on the description provided, the intent is to strengthen clinical research by funding rigorous development, testing, and validation of outcome measures for use in clinical trials and other human studies, rather than simply encouraging more clinical studies without improving the endpoints.
Why are strong outcome measures particularly important in oral and craniofacial research?
The FOA notes that many oral and craniofacial conditions involve complex functional, structural, and patient-experienced impacts that traditional clinical endpoints may not capture well, making rigorous outcome measurement development especially important.
How can improved outcome measures help the research field over time?
The FOA describes several long-term benefits: helping standardize endpoints, improving comparability across studies, reducing ambiguity in interpreting results, increasing confidence in findings, supporting regulatory or clinical decision-making, and making it easier to pool or compare data across sites and populations.
Who is eligible to apply for PAR-13-379?
Eligibility is broad and includes many U.S.-based organization types, including institutions of higher education (public/state-controlled and private), nonprofit organizations (including 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations other than small businesses, and various government entities (state, county, city or township, special districts, independent school districts, and public housing authorities/Indian housing authorities).
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA explicitly highlights additional eligible applicant categories such as HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, faith-based or community-based organizations, and regional organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly listed among eligible applicant categories.
Are eligible federal agencies allowed to apply?
Yes. The FOA includes eligible federal agencies among the listed eligible applicant categories.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Can a U.S. organization apply if the project includes a non-U.S. component?
No. The FOA states that non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this FOA?
No. The FOA indicates that foreign components, as defined by NIH policy, are not allowed.
When was this funding opportunity posted?
The FOA was posted on October 23, 2013.
What were the original and final closing dates?
The FOA lists an original and final closing date of September 7, 2015.
Is this FOA still active?
No. The opportunity was archived on October 8, 2015.
Does this FOA require cost sharing or matching?
No. The FOA does not require cost sharing or matching.
Where were the official posting and full announcement details provided?
The official posting and full announcement details were provided through the NIH grants guide.
Who should be contacted if there are access or linking issues with the announcement?
The FOA directs applicants experiencing access or linking issues to contact the NIH Office of Extramural Research (OER) webmaster.
What is the overall goal of PAR-13-379 in one sentence?
To strengthen the foundation of clinical research in oral and craniofacial health by funding the rigorous development, testing, and validation of dependable and interpretable outcome measures.
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