Opportunity Information: Apply for PAR 13 380
Apply for PAR 13 380
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Oct 23, 2013 and posted on Oct 23, 2013.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments County governments Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments Small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21) (Funding Opportunity Number PAR-13-380) is a National Institutes of Health discretionary grant opportunity designed to strengthen the tools researchers use to measure clinical outcomes in oral and craniofacial health research. The central purpose of the announcement is to fund projects that develop well-founded outcome measures for clinical studies of oral and craniofacial diseases and conditions, with particular emphasis on demonstrating that those measures are reliable and valid. In practical terms, the program is aimed at improving how investigators quantify change in symptoms, function, disease status, patient experience, or other clinically meaningful endpoints so that clinical studies and trials in dentistry and craniofacial research can produce results that are more interpretable, comparable across studies, and useful for decision-making.
This opportunity uses the NIH R21 mechanism, which is commonly associated with early-stage, exploratory, or developmental research. Within this context, the R21 is being used to support the creation, refinement, and initial testing of outcome measures rather than large-scale clinical trials. The announcement highlights two core scientific expectations: reliability (the measure performs consistently, for example across raters, sites, time, or administration modes) and validity (the measure truly captures the construct it claims to measure and supports meaningful clinical interpretation). The intent is to help the field move beyond loosely defined or inconsistent endpoints by supporting outcome measures that have a solid psychometric or measurement foundation and can be credibly used in later-stage clinical research.
The program falls under the NIH health-related funding activity area and is associated with CFDA number 93.121, Oral Diseases and Disorders Research. It does not require cost sharing or matching, which means applicants are not expected to contribute non-federal funds as a condition of the award. The award ceiling listed for this opportunity is $200,000, indicating the maximum amount that could be requested under the terms summarized in the provided data.
A wide range of applicant organizations are eligible, reflecting NIH's broad approach to supporting biomedical and behavioral research capacity across sectors. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, as specified), for-profit organizations (including small businesses and other for-profits), and various levels of government such as state, county, city or township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility information also explicitly includes several categories of mission-focused or community-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain tribal entities (including both federally recognized and other than federally recognized tribal governments, as described).
At the same time, the opportunity sets clear limits on foreign involvement. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are not allowed. These restrictions indicate that the funded work is intended to be led and conducted within eligible U.S.-based organizational structures without foreign components under NIH definitions.
In terms of administrative timing, the opportunity was posted and created on October 23, 2013, with an original and current closing date of September 7, 2015. The archive date is October 8, 2015, which typically indicates the announcement is no longer active for new submissions under that specific FOA version, though NIH sometimes reissues related opportunities under new numbers or updated announcements. For applicants or interested parties seeking the original full text, the additional information link provided points to the NIH funding announcement page: http://grants.nih.gov/grants/guide/pa-files/PAR-13-380.html.
For technical issues accessing the announcement or linking to it, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. This is a support contact for access and connectivity problems rather than a scientific or programmatic contact for project fit, but it is the resource identified in the source information for troubleshooting.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Establishing Outcome Measures for Clinical Studies of Oral and Craniofacial Diseases and Conditions (R21).
What is the funding opportunity number (FOA)?
The funding opportunity number is PAR-13-380.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the main purpose of PAR-13-380?
The central purpose is to fund projects that develop well-founded outcome measures for clinical studies of oral and craniofacial diseases and conditions, with an emphasis on demonstrating that those measures are reliable and valid.
What does NIH mean by "outcome measures" in this program?
In practical terms, the program is focused on improving how investigators quantify clinically meaningful endpoints, such as change in symptoms, function, disease status, patient experience, or other endpoints that matter for interpreting clinical research results.
What types of projects does the R21 mechanism support in this announcement?
This opportunity uses the NIH R21 mechanism, which is commonly associated with early-stage, exploratory, or developmental research. Here, it is used to support the creation, refinement, and initial testing of outcome measures rather than large-scale clinical trials.
Is this opportunity intended to fund large clinical trials?
No. Based on the description provided, the R21 is being used to support development work on outcome measures and their initial testing, not large-scale clinical trials.
What are the two core scientific expectations for measures developed under this FOA?
The announcement highlights two core expectations: reliability (consistent performance across raters, sites, time, or administration modes) and validity (the measure captures the construct it claims to measure and supports meaningful clinical interpretation).
What does "reliability" mean in the context of this FOA?
Reliability refers to whether the measure performs consistently, for example across different raters, different study sites, different time points, or different ways of administering the measure.
What does "validity" mean in the context of this FOA?
Validity refers to whether the measure truly captures what it claims to measure and whether the results support meaningful clinical interpretation.
Why is NIH emphasizing reliable and valid measures here?
The stated intent is to help the field move beyond loosely defined or inconsistent endpoints by supporting outcome measures with a solid measurement foundation, so that later clinical studies can produce results that are more interpretable, more comparable across studies, and more useful for decision-making.
What research area does this program fall under?
The program falls under an NIH health-related funding activity area and is associated with CFDA 93.121, Oral Diseases and Disorders Research.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching, meaning applicants are not expected to contribute non-federal funds as a condition of the award.
What is the maximum award amount mentioned for this opportunity?
The award ceiling listed is $200,000, indicating the maximum amount that could be requested under the summarized terms provided.
What types of organizations are eligible to apply?
Eligibility includes a wide range of organization types, including:
- Public and private institutions of higher education
- Nonprofits (including those with and without 501(c)(3) status, as specified)
- For-profit organizations (including small businesses and other for-profits)
- State, county, city or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Eligible federal agencies
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Tribal entities, including federally recognized tribal governments and other than federally recognized tribal governments (as described)
Are mission-focused or minority-serving institutions included in eligibility?
Yes. The eligibility information explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign (non-U.S.) institutions eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply under this opportunity.
Can a U.S. organization apply if it plans to carry out work through a non-domestic component?
No. The opportunity states that non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed under NIH definitions?
No. The opportunity specifies that foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
When was this opportunity posted?
The opportunity was posted and created on October 23, 2013.
What was the closing date for PAR-13-380?
The original and current closing date listed is September 7, 2015.
What does the archive date indicate?
The archive date is October 8, 2015, which typically indicates the announcement is no longer active for new submissions under that specific FOA version.
Where can applicants find the original NIH funding announcement text?
The additional information link provided is: http://grants.nih.gov/grants/guide/pa-files/PAR-13-380.html
Who is listed as the contact for technical problems accessing the announcement?
The contact listed for access and connectivity issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed contact intended for scientific or programmatic questions about project fit?
No. The information provided describes this as a support contact for technical issues (access/connectivity) rather than a scientific or programmatic contact.
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