Opportunity Information: Apply for PA 12 255
Apply for PA 12 255
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 6, 2012 and posted on Aug 6, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Special district governments State governments Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity PA-12-255, titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R01)," is a discretionary research grant announcement focused on improving what is known about the financial and economic burden associated with Alzheimers disease and other dementias. The central premise is that while these conditions are widely assumed to be extremely costly to society, the true size and structure of those costs remain uncertain. NIH is therefore inviting rigorous research that can quantify and clarify the full economic footprint of dementia, using methods and data sources that can produce credible estimates and help resolve gaps or inconsistencies in existing evidence.
The scope of work emphasized by the announcement is broad and intentionally includes multiple categories of cost. It calls for studies that measure direct medical and health care spending as well as indirect costs that often fall outside traditional health expenditure accounting. Direct costs can include payments and utilization tied to care delivered through public programs and private insurers, such as hospitalizations, physician services, medications, long-term services and supports, home health care, skilled nursing facility care, and other covered benefits. At the same time, the FOA highlights the importance of understanding costs borne by families and informal caregivers, reflecting the reality that a substantial share of dementia-related care is provided outside formal medical settings. This includes the economic value of unpaid caregiving time, out-of-pocket spending, and other household-level financial consequences that may not be captured in claims-based datasets.
A distinctive feature of this opportunity is its explicit attention to labor market and productivity impacts. NIH encourages work that examines how dementia affects employment and earnings for patients and for family members who adjust work hours, reduce labor force participation, or exit the workforce to provide care. That means the opportunity supports analyses that connect disease progression and caregiving demands with reduced productivity, lost wages, foregone career advancement, and broader macroeconomic implications. In practical terms, the FOA is pointing applicants toward comprehensive economic models of burden that incorporate both the health system perspective and the societal perspective, including spillover effects on caregivers and employers.
The award mechanism is the NIH R01, which generally supports investigator-initiated, hypothesis-driven research projects and can accommodate a range of quantitative approaches. Applicants might use longitudinal cohort studies, administrative claims, survey data, electronic health records, linked datasets, or economic modeling to estimate incremental costs attributable to dementia compared with appropriate control groups. Studies may also examine how costs vary by disease stage, care setting, comorbidities, demographic characteristics, payer type, geography, and access to services. The overall intent is to produce estimates that are policy-relevant, methodologically defensible, and useful for planning in both public programs and private markets.
In terms of administrative details, this was posted on August 6, 2012 and had an original and final closing date of September 7, 2015, with an archive date of October 8, 2015. The activity category is health, and it is associated with CFDA 93.866 (Aging Research). There is no cost sharing or matching requirement, which means applicants were not expected to commit non-federal matching funds as a condition of the award.
Eligibility is expansive and reflects NIH norms for research grant competitions. Eligible applicants include state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; independent school districts; and various tribal entities and housing authorities. The eligibility language also explicitly includes a wide range of mission-based and capacity-building institution types such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and federal agencies. Importantly, the FOA allows non-U.S. entities to apply, permits non-U.S. components of U.S. organizations, and allows foreign components consistent with the NIH Grants Policy Statement, signaling openness to international expertise and cross-national research where appropriate.
For anyone seeking the full archived announcement, NIH provided an official link through the NIH grants guide (http://grants.nih.gov/grants/guide/pa-files/PA-12-255.html). For access or technical issues related to the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs) - NIH PA-12-255: Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R01)
What is NIH funding opportunity PA-12-255?
PA-12-255 is an NIH discretionary research grant announcement titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R01)." It invites rigorous research to quantify and clarify the financial and economic burden of Alzheimers disease and other dementias, because the overall size and structure of these costs are still uncertain.
What is the main goal of this funding opportunity?
The goal is to support methodologically strong studies that can produce credible estimates of the full economic footprint of dementia and help resolve gaps or inconsistencies in existing evidence about dementia-related costs.
What grant mechanism does this opportunity use?
The award mechanism is the NIH R01, which generally supports investigator-initiated, hypothesis-driven research projects and can accommodate a range of quantitative approaches.
What types of costs is NIH interested in measuring?
The scope is broad and includes multiple categories of cost, including direct medical and health care spending and indirect costs that may not appear in traditional health expenditure accounting.
What are examples of direct medical and health care costs mentioned in the announcement?
Examples include payments and utilization tied to care delivered through public programs and private insurers, such as hospitalizations, physician services, medications, long-term services and supports, home health care, skilled nursing facility care, and other covered benefits.
Does the opportunity include costs borne by families and informal caregivers?
Yes. A highlighted emphasis is understanding costs borne by families and informal caregivers, since a substantial share of dementia-related care is provided outside formal medical settings.
What kinds of caregiver and household costs are in scope?
The announcement explicitly points to the economic value of unpaid caregiving time, out-of-pocket spending, and other household-level financial consequences that may not be captured in claims-based datasets.
Is labor market and productivity impact part of the research scope?
Yes. A distinctive feature of the opportunity is its explicit attention to labor market and productivity impacts related to dementia.
Whose employment and earnings effects can be studied under this FOA?
NIH encourages research on how dementia affects employment and earnings for patients, and for family members who adjust work hours, reduce labor force participation, or leave the workforce to provide care.
What kinds of productivity-related outcomes does NIH encourage applicants to examine?
The FOA points toward analyses of reduced productivity, lost wages, foregone career advancement, and broader macroeconomic implications, connecting disease progression and caregiving demands to economic outcomes.
Does NIH encourage a health system perspective, a societal perspective, or both?
Both. The FOA steers applicants toward comprehensive economic models of burden that incorporate the health system perspective and the societal perspective, including spillover effects on caregivers and employers.
What kinds of study designs or methods are suggested?
The announcement indicates that a range of quantitative approaches may be used, including longitudinal cohort studies and economic modeling, among others, as long as they can generate credible estimates.
What data sources are mentioned as potentially usable for cost estimation?
Examples listed include administrative claims, survey data, electronic health records, linked datasets, and longitudinal cohort data, as well as economic modeling approaches.
What kind of comparisons does NIH anticipate for estimating incremental costs?
The FOA mentions estimating incremental costs attributable to dementia compared with appropriate control groups.
Can studies examine how costs vary across different subgroups or contexts?
Yes. The announcement notes that studies may examine how costs vary by disease stage, care setting, comorbidities, demographic characteristics, payer type, geography, and access to services.
What is NIH looking for in terms of the usefulness of results?
The intent is to produce estimates that are policy-relevant, methodologically defensible, and useful for planning in both public programs and private markets.
When was this funding opportunity posted?
The announcement was posted on August 6, 2012.
What were the original and final closing dates?
The original and final closing date listed is September 7, 2015.
When was the opportunity archived?
The archive date is October 8, 2015.
What activity category is associated with this opportunity?
The activity category is health.
What CFDA number is associated with this NIH opportunity?
It is associated with CFDA 93.866 (Aging Research).
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement, meaning applicants were not expected to provide non-federal matching funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes many organization types commonly eligible under NIH research grant competitions, spanning government entities, higher education institutions, nonprofits, and for-profit organizations.
Are government entities eligible applicants?
Yes. Eligible applicants include state, county, city/township, and special district governments, as well as independent school districts and federal agencies.
Are colleges and universities eligible to apply?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) and small businesses are both included as eligible applicants.
Are tribal entities included in eligibility?
Yes. The eligibility language includes various tribal entities and also references Tribally Controlled Colleges and Universities.
Are Historically Black Colleges and Universities (HBCUs) and other mission-based institutions eligible?
Yes. The eligibility list explicitly includes Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and regional organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility language explicitly includes U.S. territories or possessions.
Can non-U.S. entities apply?
Yes. The FOA allows non-U.S. entities to apply, permits non-U.S. components of U.S. organizations, and allows foreign components consistent with the NIH Grants Policy Statement.
Where can someone find the full archived announcement?
NIH provided an official link through the NIH grants guide: http://grants.nih.gov/grants/guide/pa-files/PA-12-255.html
Who is listed as the contact for access or technical issues with the posting?
The contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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