Opportunity Information: Apply for PA 12 253
Apply for PA 12 253
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 6, 2012 and posted on Aug 6, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments State governments Private institutions of higher education County governments Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Native American tribal governments (Federally recognized) Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) offered this discretionary grant opportunity, titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R03)" (Funding Opportunity Number: PA 12 253), to support focused research that clarifies how much Alzheimers disease and related dementias (AD/ADRD) cost society. While these conditions are commonly understood to create a major economic burden, the FOA highlights that the true magnitude of those costs is still uncertain, in part because costs can be distributed across many sectors and can be difficult to measure consistently. The central purpose of the announcement is to encourage studies that produce clearer, more defensible estimates of the economic impact of AD/ADRD, using rigorous methods suitable for a smaller, exploratory R03 research grant.
The FOA emphasizes that applicants should examine both direct and indirect costs associated with dementia. Direct costs can include medical and health care spending borne by public and private payers, such as Medicare, Medicaid, private insurance, and out-of-pocket spending by patients and families. Indirect costs can include the substantial time and financial burden placed on families and informal caregivers, such as unpaid caregiving hours, lost wages, and reduced career advancement. The announcement also explicitly encourages work on labor market impacts, including reduced productivity, early retirement, diminished labor force participation, and other employment-related effects that arise when individuals develop dementia or when caregivers cut back work to provide support. In other words, the opportunity is designed to move beyond narrow medical spending tallies and toward a fuller accounting of how dementia affects households, employers, and the broader economy.
This opportunity falls under the NIH health research activity category and is associated with CFDA number 93.866 (Aging Research). It did not require cost sharing or matching. The FOA was posted on August 6, 2012, and remained open through September 7, 2015, with an archive date of October 8, 2015. As an R03 mechanism, it is generally intended for discrete, well-defined projects that can generate useful preliminary evidence, develop or refine methods, or address targeted questions that help improve measurement of economic costs in this field.
Eligibility was broad and included many types of U.S. organizations and governments, such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. It also included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories), small businesses, and for-profit organizations (other than small businesses). Tribal entities were eligible as well, including federally recognized tribal governments and other tribal organizations. The FOA further clarified additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, foreign institutions were also eligible to apply, along with non-U.S. components of U.S. organizations, and foreign components were allowed as defined by the NIH Grants Policy Statement, reflecting NIHs openness to research teams and data sources beyond the United States when scientifically justified.
For applicants or institutions needing the complete announcement details, NIH provided an official link to the funding notice (http://grants.nih.gov/grants/guide/pa-files/PA-12-253.html). NIH also listed support contacts through the NIH Office of Extramural Research (OER) Webmaster for technical access or linking problems (FBOWebmaster@OD.NIH.GOV). Overall, the grant opportunity was aimed at strengthening the evidence base on the economic burden of dementia by supporting studies that can better capture the full range of costs across health systems, families, and the labor market, ultimately helping inform policy, planning, and resource allocation.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R03)" and the Funding Opportunity Number (FON) is PA 12 253.
What is the main purpose of this funding opportunity?
The central purpose is to support focused research that produces clearer, more defensible estimates of the economic impact of Alzheimers disease and related dementias (AD/ADRD). The FOA emphasizes that the true magnitude of these costs is still uncertain and encourages rigorous methods appropriate for a smaller, exploratory R03 grant.
Why does NIH say the economic costs of AD/ADRD are still uncertain?
The FOA notes that costs can be distributed across many sectors and can be difficult to measure consistently. Because the burden is not confined to medical spending alone, and because different studies may measure costs differently, the overall magnitude can remain unclear without stronger, more standardized approaches.
What types of costs does the FOA ask applicants to examine?
The FOA emphasizes examining both direct and indirect costs associated with dementia, aiming for a fuller accounting of how AD/ADRD affects health systems, families, employers, and the broader economy.
What are examples of direct costs mentioned in the FOA?
Direct costs can include medical and health care spending borne by public and private payers, including Medicare, Medicaid, private insurance, and out-of-pocket spending by patients and families.
What are examples of indirect costs mentioned in the FOA?
Indirect costs can include the time and financial burden placed on families and informal caregivers, such as unpaid caregiving hours, lost wages, and reduced career advancement.
Does the FOA specifically encourage research on labor market impacts?
Yes. The announcement explicitly encourages work on labor market impacts, including reduced productivity, early retirement, diminished labor force participation, and other employment-related effects when individuals develop dementia or when caregivers reduce work to provide support.
Is this opportunity limited to medical spending estimates?
No. The FOA is designed to move beyond narrow tallies of medical spending and toward broader estimates that reflect impacts across households, employers, and the wider economy.
What grant mechanism is used (and what does that imply about project scope)?
This is an NIH R03 mechanism. As described in the FOA summary, R03 projects are generally intended to be discrete and well-defined, often supporting preliminary evidence generation, method development or refinement, or targeted questions that improve measurement of economic costs in this field.
What is the activity category and CFDA number associated with this opportunity?
The opportunity falls under the NIH health research activity category and is associated with CFDA number 93.866 (Aging Research).
Was cost sharing or matching required?
No. The FOA states that cost sharing or matching was not required.
When was the FOA posted, and what were the open and archive dates?
The FOA was posted on August 6, 2012. It remained open through September 7, 2015, and has an archive date of October 8, 2015.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations and governments as well as foreign institutions and foreign components (as defined by NIH policy). The FOA lists a wide range of eligible applicant types spanning government entities, higher education, nonprofits, and businesses.
Are U.S. state and local government entities eligible?
Yes. Eligible U.S. government entities include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are universities and colleges eligible?
Yes. Eligibility includes public and state-controlled institutions of higher education as well as private institutions of higher education.
Are nonprofit organizations eligible?
Yes. The FOA includes nonprofits with and without 501(c)(3) status (excluding higher education institutions within those nonprofit categories, as stated in the eligibility description).
Are small businesses and for-profit organizations eligible?
Yes. The FOA lists small businesses as eligible, and also includes for-profit organizations (other than small businesses).
Are tribal entities eligible to apply?
Yes. Eligibility includes federally recognized tribal governments and other tribal organizations.
Does the FOA mention eligibility for specific institution types such as HBCUs or Hispanic-serving institutions?
Yes. The FOA explicitly lists additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based and community-based organizations eligible?
Yes. The FOA includes faith-based or community-based organizations among the additional eligible applicants.
Are U.S. territories or possessions included in eligibility?
Yes. The FOA lists U.S. territories or possessions among eligible applicants.
Are eligible federal agencies allowed to apply?
Yes. The FOA includes eligible federal agencies in the eligibility list.
Can foreign institutions apply?
Yes. The FOA states that foreign institutions were eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA indicates that non-U.S. components of U.S. organizations were eligible.
Are foreign components allowed under this opportunity?
Yes. Foreign components were allowed as defined by the NIH Grants Policy Statement, reflecting openness to research teams and data sources beyond the United States when scientifically justified.
Where can applicants find the full official FOA text?
The FOA provides an official NIH link: http://grants.nih.gov/grants/guide/pa-files/PA-12-253.html
Who should be contacted for technical access or linking problems related to the announcement?
NIH listed the NIH Office of Extramural Research (OER) Webmaster for technical access or linking problems: FBOWebmaster@OD.NIH.GOV
What broader impact is NIH aiming for with this research?
The opportunity aims to strengthen the evidence base on the economic burden of dementia by supporting studies that better capture costs across health systems, families, and the labor market, helping inform policy, planning, and resource allocation.
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