Opportunity Information: Apply for PA 12 254
Apply for PA 12 254
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 6, 2012 and posted on Aug 6, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Small businesses Special district governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts City or township governments County governments Public and State controlled institutions of higher education State governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity announcement PA 12-254, titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R21)," supports exploratory research aimed at producing clearer, more credible estimates of the economic burden associated with Alzheimers disease and other dementias. The core motivation behind the announcement is that these conditions are widely understood to create substantial costs for society, yet existing estimates vary widely and often suffer from data limitations, inconsistent methods, and incomplete accounting of who bears the costs. NIH is encouraging studies that strengthen the evidence base by improving measurement, defining cost components more rigorously, and capturing economic impacts that extend beyond the formal health care system.
A central focus of this opportunity is the full range of costs tied to dementia, including both direct and indirect costs. Direct costs include medical and health care spending covered by public payers (such as Medicare and Medicaid) and private insurers, along with out-of-pocket spending by patients and families. Indirect costs are emphasized as well, particularly costs that are often undercounted or methodologically difficult to quantify, such as the economic value of informal caregiving provided by family members or friends. The announcement also highlights labor market impacts, recognizing that dementia can reduce productivity, limit employment, or push individuals and caregivers to reduce work hours or exit the labor force altogether. In practical terms, NIH is inviting research that connects clinical and functional decline to real-world economic outcomes for patients, caregivers, employers, and government programs.
Because this is an R21 mechanism, the intent is to fund early-stage, high-impact, or method-development projects that can test novel ideas, assemble new datasets, refine analytic approaches, or generate preliminary evidence that can later be expanded through larger research awards. The award ceiling listed is $200,000, and there is no cost-sharing or matching requirement. The activity category is health, and it falls under CFDA 93.866 (Aging Research), signaling a strong alignment with aging, long-term care, and dementia-related policy questions. Overall, the grant is geared toward research that can clarify the magnitude and distribution of dementia costs, improve comparability across studies, and help decision-makers understand which cost drivers matter most.
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include small businesses, other for-profit organizations, nonprofits (including those with and without 501(c)(3) status), public and private institutions of higher education, and a wide range of government entities such as city/township, county, state, and tribal governments, as well as special district governments and independent school districts. The eligibility language also explicitly notes categories such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign institutions. In addition, non-U.S. components of U.S. organizations may apply, and foreign components are allowed consistent with NIH policy, indicating NIH was open to international perspectives or cross-country data where appropriate.
Administratively, the opportunity is categorized as a discretionary grant. It was posted and created on August 6, 2012, with an original and current closing date of September 7, 2015, and an archive date of October 8, 2015. While the announcement itself is now archived, the description is useful for understanding the kinds of projects NIH prioritized: careful economic measurement of dementia burden across payers and families, the valuation of informal care, and quantification of employment and productivity effects. The full announcement was made available through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-12-254.html, and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is the National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) PA 12-254, titled "Estimating the Economic Costs of Alzheimers Disease and Related Dementias (R21)." It supports exploratory research to produce clearer, more credible estimates of the economic burden of Alzheimers disease and other dementias.
What is the main goal of PA 12-254?
The goal is to strengthen the evidence base on the economic costs of dementia by improving measurement, defining cost components more rigorously, and capturing economic impacts that extend beyond the formal health care system. NIH is responding to the fact that existing cost estimates vary widely and may rely on inconsistent methods, incomplete accounting, or data limitations.
What types of research does this FOA emphasize?
NIH emphasizes exploratory, early-stage, high-impact, and method-development work that can improve how dementia-related economic burden is measured and compared across studies. This includes refining analytic approaches, assembling new datasets, and generating preliminary evidence that could be expanded later through larger research awards.
What funding mechanism is used?
The FOA uses the NIH R21 mechanism, which is intended for exploratory and developmental research projects.
What is the award ceiling?
The award ceiling listed for this opportunity is $200,000.
Is cost-sharing or matching required?
No. The opportunity specifies that there is no cost-sharing or matching requirement.
What cost categories are included in the "economic costs" NIH is interested in?
NIH highlights a full range of costs tied to dementia, including both direct and indirect costs, and encourages more complete and consistent accounting of who bears those costs.
What are considered direct costs under this announcement?
Direct costs include medical and health care spending covered by public payers (such as Medicare and Medicaid) and private insurers, as well as out-of-pocket spending by patients and families.
What are considered indirect costs under this announcement?
Indirect costs include impacts that are often undercounted or harder to quantify, especially the economic value of informal caregiving provided by family members or friends.
Does the opportunity specifically mention informal caregiving?
Yes. A key emphasis is valuing informal caregiving and addressing the methodological challenges that often lead to informal care being undercounted in economic burden estimates.
Does the opportunity address employment and productivity effects?
Yes. NIH highlights labor market impacts, noting that dementia can reduce productivity, limit employment, or lead patients and caregivers to reduce work hours or leave the labor force. Studies that link clinical and functional decline to real-world labor and productivity outcomes are encouraged.
Who does NIH want researchers to consider as bearing dementia-related costs?
The FOA points to costs affecting patients, families and caregivers, employers, government programs, public payers, and private insurers. A core motivation is improving clarity about how costs are distributed across these groups.
What is the activity category for this opportunity?
The activity category is health.
What CFDA program is associated with this opportunity?
The opportunity is associated with CFDA 93.866 (Aging Research).
What kinds of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include small businesses; other for-profit organizations; nonprofits (with or without 501(c)(3) status); public and private institutions of higher education; and many government entities such as city/township, county, state, and tribal governments, as well as special district governments and independent school districts.
Are minority-serving and mission-based institutions included in the eligibility language?
Yes. The eligibility language explicitly notes categories such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility language explicitly includes U.S. territories or possessions.
Are foreign institutions eligible to apply?
Yes. The eligibility language includes foreign institutions, and also notes that non-U.S. components of U.S. organizations may apply and that foreign components are allowed consistent with NIH policy.
What does it mean that this is a discretionary grant?
The opportunity is categorized administratively as a discretionary grant.
When was the opportunity posted and created?
It was posted and created on August 6, 2012.
What was the closing date for applications?
The original and current closing date listed is September 7, 2015.
Is this funding opportunity still open?
No. The announcement is archived. The archive date listed is October 8, 2015.
Where can the full announcement be found?
The FOA was made available through NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-12-254.html
Who is listed as a contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
What kinds of outcomes does NIH want studies to connect to dementia progression?
NIH invites research connecting clinical and functional decline to real-world economic outcomes for patients, caregivers, employers, and government programs.
Why is NIH encouraging new work in this area?
The FOA notes that dementia is widely understood to impose substantial societal costs, but estimates vary widely due to limitations such as inconsistent methods, incomplete accounting of cost bearers, and data constraints. NIH is encouraging work that improves credibility and comparability across studies and clarifies key cost drivers.
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