Opportunity Information: Apply for RFA HD 14 026
Apply for RFA HD 14 026
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Evaluation of the Latent Reservoir in HIV Infected Infants and Children with Early Antiretroviral Treatment and Virologic Control (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Feb 11, 2013 and posted on Feb 6, 2013.
- Applicants must submit their applications by Aug 30, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,900,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Public and State controlled institutions of higher education Independent school districts Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities City or township governments Small businesses For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) released this Funding Opportunity Announcement (FOA), RFA-HD-14-026, to support research focused on the latent HIV reservoir in infants and children who began antiretroviral therapy (ART) early in life (with initiation by about 6 months of age) and who have maintained continuous virologic suppression. The central scientific goal is to better understand where and how HIV persists in the body despite effective treatment in pediatric cases treated early, since the latent reservoir is widely considered a major barrier to long-term remission or cure. The FOA is specifically aimed at studies that can characterize, measure, and otherwise evaluate these persistent HIV reservoirs under conditions where standard clinical testing shows viral control, recognizing that suppressed plasma viral load does not necessarily mean the virus has been eliminated.
The opportunity uses the NIH R01 research project grant mechanism, meaning it is intended for hypothesis-driven, investigator-initiated research projects rather than small pilot activities. NIH indicates that studies may be conducted in either developed or developing country settings, which reflects the global distribution of pediatric HIV and the fact that early-treatment cohorts may exist in multiple regions. In addition to human studies, the FOA also allows proposals to create new animal models or adapt existing animal models that mimic perinatal HIV infection followed by early ART and sustained suppression. That animal-model emphasis is important because it can enable more intensive tissue-based sampling and mechanistic experiments that are often not feasible in children, while still remaining relevant to pediatric infection and early treatment.
From a funding standpoint, NIH listed an estimated total program funding level of about $2.9 million for the announcement, with a maximum award amount (award ceiling) of $750,000 per award. The announcement states there is no cost sharing or matching requirement, which typically lowers administrative and financial barriers for applicants because they are not required to contribute non-federal funds to the project budget.
Eligibility is broad and includes many common U.S. and non-U.S. research-performing entities. Eligible applicants include nonprofit organizations (both 501(c)(3) and other nonprofit types), public and private institutions of higher education, state and local government entities (including county governments, city or township governments, independent school districts, and special district governments), tribal governments and tribal organizations (including federally recognized tribes), public housing authorities/Indian housing authorities, small businesses, and for-profit organizations (with eligibility distinctions noted for small businesses versus other for-profits). The FOA explicitly allows non-U.S. entities and foreign institutions to apply, permits non-U.S. components of U.S. organizations to participate, and allows foreign components as defined in the NIH Grants Policy Statement. It also highlights eligibility for a wide range of mission- and population-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations and eligible federal agencies.
Administratively, this FOA was posted on February 6, 2013, created on February 11, 2013, and had an original and current closing date of August 30, 2013, with an archive date of September 30, 2013. The listing categorizes the activity area under Health and references multiple CFDA numbers tied to mental health research and infectious disease research, including allergy and infectious diseases, microbiology and infectious diseases, and child health and human development extramural research, reflecting the cross-cutting nature of pediatric HIV reservoir science across NIH institutes and research domains.
In practical terms, the FOA is seeking projects that can advance the field’s ability to define the size, distribution, and biological behavior of HIV that remains hidden in the body of early-treated, well-controlled children. By supporting both clinical cohort-based studies and relevant perinatal/early-treatment animal model development, the announcement is designed to strengthen the evidence base needed for pediatric HIV remission and cure strategies, including better reservoir measurement tools and a clearer understanding of persistence even when standard treatment is highly successful.
Frequently Asked Questions (FAQs)
What is the purpose of NIH FOA RFA-HD-14-026?
This Funding Opportunity Announcement (RFA-HD-14-026) supports research on the latent HIV reservoir in infants and children who started antiretroviral therapy (ART) early in life (with initiation by about 6 months of age) and who have maintained continuous virologic suppression. The goal is to better understand where and how HIV persists despite effective treatment, since the latent reservoir is considered a major barrier to long-term remission or cure.
What is the central scientific focus of the research being requested?
The FOA emphasizes studies that can characterize, measure, and evaluate persistent HIV reservoirs in early-treated pediatric cases under conditions where standard clinical testing indicates viral control. A key point in the announcement is that a suppressed plasma viral load does not necessarily mean HIV has been eliminated.
Who is the target population for human studies under this FOA?
The target population is infants and children who began ART early (by about 6 months of age) and have maintained continuous virologic suppression. The FOA is focused on pediatric cases treated early in life.
Does this FOA support research in both developed and developing countries?
Yes. NIH indicates that studies may be conducted in either developed or developing country settings, reflecting the global distribution of pediatric HIV and the presence of early-treatment cohorts in multiple regions.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 research project grant mechanism, which is intended for hypothesis-driven, investigator-initiated research projects rather than small pilot activities.
Are animal model studies allowed under this FOA?
Yes. In addition to human studies, the FOA allows proposals to create new animal models or adapt existing animal models that mimic perinatal HIV infection followed by early ART and sustained virologic suppression.
Why does the FOA include an emphasis on animal models?
The animal-model option is highlighted as important because it can enable more intensive tissue-based sampling and mechanistic experiments that are often not feasible in children, while still being relevant to perinatal infection and early treatment in pediatric contexts.
What types of research activities does the FOA aim to advance?
The FOA is aimed at advancing the ability to define the size, distribution, and biological behavior of HIV that remains hidden in the body of early-treated, well-controlled children. This includes improving reservoir measurement tools and strengthening understanding of persistence even when standard treatment is highly successful.
How much funding is available under this FOA?
NIH listed an estimated total program funding level of about $2.9 million for the announcement.
Is there a maximum award amount (award ceiling) per award?
Yes. The FOA lists a maximum award amount (award ceiling) of $750,000 per award.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes U.S. and non-U.S. research-performing entities. Eligible applicants include nonprofit organizations (including 501(c)(3) and other nonprofit types), public and private institutions of higher education, state and local governments (including county governments, city or township governments, independent school districts, and special district governments), tribal governments and tribal organizations (including federally recognized tribes), public housing authorities/Indian housing authorities, small businesses, and for-profit organizations (with eligibility distinctions noted for small businesses versus other for-profits).
Are foreign institutions allowed to apply?
Yes. The FOA explicitly allows non-U.S. entities and foreign institutions to apply. It also permits non-U.S. components of U.S. organizations to participate and allows foreign components as defined in the NIH Grants Policy Statement.
Does the FOA highlight any specific institution types as eligible?
Yes. The FOA highlights eligibility for a wide range of mission- and population-focused institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations, and eligible federal agencies.
When was the FOA posted and when did it close?
The FOA was posted on February 6, 2013, created on February 11, 2013, and had an original and current closing date of August 30, 2013. The archive date is September 30, 2013.
What does the FOA say about virologic suppression and HIV persistence?
The FOA recognizes that suppressed plasma viral load in standard clinical testing does not necessarily mean HIV has been eliminated, and it specifically seeks research that can evaluate persistent HIV reservoirs under conditions of apparent viral control.
Which activity area is this FOA categorized under?
The listing categorizes the activity area under Health.
Are CFDA numbers associated with this FOA, and what areas do they reflect?
Yes. The listing references multiple CFDA numbers tied to mental health research and infectious disease research, including allergy and infectious diseases, microbiology and infectious diseases, and child health and human development extramural research. This reflects the cross-cutting nature of pediatric HIV reservoir science across NIH institutes and research domains.
What overall impact is NIH aiming for with this FOA?
By supporting both clinical cohort-based studies and relevant perinatal/early-treatment animal model development, the FOA is designed to strengthen the evidence base needed for pediatric HIV remission and cure strategies, including better reservoir measurement tools and a clearer understanding of how HIV persists despite early treatment and sustained suppression.
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